1. Scottish Intercollegiate Guidelines Network. SIGN 50 A guideline developer’s handbook [Internet]. Edinburgh: Scottish Intercollegiate Guidelines Network; 2008 [actualizado nov 2011; citado 28 mar 2014]. Disponible en: http://www.sign.ac.uk/pdf/sign50.pdf
2. Cano Arana A, González Gil T, Cabello López JB, CASPe. Plantilla para ayudarte a entender un estudio cualitativo. En: CASPe. Guías CASPe de Lectura Crítica de la Literatura Médica. Alicante: CASPe; 2010. Cuaderno III. p.3-8.
3. Goldsmith M, Bankhead C, Austoker J. Improving the quality of the written information sent to women about breast screening. Sheffield: NHS Cancer Screening Programmes; 2007. Informe Nº.: 64.
4. World Health Organization. Depression. Geneva: World Health Organization; 2013 [citado 10 dic 2013]. Disponible en: http://www.who.int/topics/depression/en/
5. World Health Organization. Mental health action plan 2013 – 2020. Geneva: WHO; 2012 [citado 10 dic 2013]. [aprox. 2 pantallas]. Disponible en: http://www.who.int/mental_health/ publications/action_plan/en/index.html.
6. Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA. 2003;289(23):3095-105.
7. Gabilondo A, Rojas-Farreras S, Vilagut G, Haro JM, Fernández A, Pinto-Meza A, et al. Epidemiology of major depressive episode in a southern European country: Results from the ESEMeD-Spain project. J Affect Disord. 2010;120(1-3):76-85.
8. Crespo D, Gil A, Porras Chavarino A, Grupo de Investigación en Depresión y Psiquiatría de Enlace. Prevalencia de los trastornos depresivos en psiquiatría de enlace. Actas Esp Psiquiatr. 2001;29(2):75-83.
9. Barro Lugo S, Saus Arús M, Barro Lugo A, M. FM. Depresión y ansiedad en inmigrantes no regularizados. Aten Primaria. 2004;34(9):504.
10. Curran C, Knapp M, McDaid D, Tomasson K, The MHEEN Group. Mental health and employment: An overview of patterns and policies across Western Europe. Journal of Mental Health. 2007;16(2):195-209.
11. Sobocki P, Jönsson B, Angst J, Rehnberg C. Cost of depression in Europe. J Ment Health Policy Econ. 2006;9(2):87-98.
12. Gabilondo A, Rojas-Farreras S, Rodríguez A, Fernández A, Pinto-Meza A, Vilagut G, et al. Use of primary and specialized mental health care for a major depressive episode in Spain by ESEMeD respondents. Psychiatr Serv. 2011;62(2):152-61.
13. National Collaborating Centre for Mental Health. Depression. The treatment and management of depression in adults. London: The British Psychological Society; 2009. Informe No.: 90.
14. Patten SB, Kennedy SH, Lam RW, O’Donovan C, Filteau MJ, Parikh SV, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) Clinical Guidelines for the Management of Major Depressive Disorder in Adults. I. Classification, Burden and Principles of Management. J Affect Disord. 2009;117 Suppl 1:S5-14.
15. Aragonès E, Piñol JL, Labad A, Folch S, Mèlich N. Detection and management of depressive disorders in primary care in Spain. Int J Psychiatry Med. 2004;34(4):331-43.
16. Kupfer DJ, Frank E, Phillips ML. Major depressive disorder: new clinical, neurobiological, and treatment perspectives. Lancet. 2012;379(9820):1045-55.
17. Adán-Manes J, Ayuso-Mateos JL. [Over-diagnosis and over-treatment of major depressive disorder in primary care. An increasing phenomenon]. Aten Primaria. 2010;42(1):47-9.
18. Grupo de trabajo sobre GPC. Elaboración de guías de práctica clínica en el Sistema Nacional de Salud. Manual Metodológico. Madrid: Instituto Aragonés de Ciencias de la Salud I+CS; 2006. Informe Nº.: I+CS Nº 2006/01.
19. Grupo de trabajo sobre actualización de GPC. Actualización de Guías de Práctica Clínica en el Sistema Nacional de Salud. Manual Metodológico. Madrid: Ministerio de Sanidad y Política Social; 2009. Guías de Práctica Clínica en el SNS: I+CS Nº 2007/02-01.
20. Grade working group [Sede web]. GRADE working group; [actualizado 2014; citado 28 mar 2014]. Disponible en: http://www.gradeworkinggroup.org/index.htm.
21. Marcus M, Yasamy MT, Ommeren Mv, Chisholm D, Saxena S, WHO Department of Mental Health and Substance Abuse. Depression. A Global Public Health Concern. Geneva: WHO.
22. Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62(6):617.
23. Egede LE. Major depression in individuals with chronic medical disorders: prevalence, correlates and association with health resource utilization, lost productivity and functional disability. General Hospital Psychiatry. 2007;29:409-16.
24. Serby M, Yu M. Overview: depression in the elderly. Mt Sinai J Med. 2003;70(1):977-86.
25. Hegeman JM, Kok RM, van der Mast RC, Giltay EJ. Phenomenology of depression in older compared with younger adults: meta-analysis. Br J Psychiatry. 2012;200(4):275-81.
26. Butler R, Carney S, Cipriani A, Geddes J, Hatcher S, Price J, et al. Depressive disorders. Am Fam Physician. 2006 73(11):1999-2004.
27. Bellón JA, Moreno-Küstner B, Torres-González F, Montón-Franco C, GildeGómez-Barragán MJ, Sánchez-Celaya M, et al. Predicting the onset and persistence of episodes of depression in primary health care. The predictD-Spain study: methodology. BMC Public Health. 2008;8:256.
28. Hamalainen J, Kaprio J, Isometsa E, Heikkinen M, Poikolainen K, Lindeman S, et al. Cigarette smoking, alcohol intoxication and major depressive episode in a representative population sample. J Epidemiol Community Health. 2001;55(8):573-6.
29. Boden JM, Fergusson DM. Alcohol and depression. Addiction. 2011;106(5):906-14.
30. Eccleston D, Scott J. Treatment, prediction of relapse and prognosis of chronic primary major depression. Int Clin Psychopharmacol. 1991;6 Suppl 2:3-10.
31. Wilhelm K, Parker G, Dewhurst-Savellis J, Asghari A. Psychological predictors of single and recurrent major depressive episodes. J Affect Disord. 1999;54(1-2):139-47.
32. Klein DN, Kotov R, Bufferd SJ. Personality and Depression: Explanatory Models and Review of the Evidence. Annu Rev Clin Psychol. 2011;7:269-95.
33. Kendler KS, Gatz M, Gardner CO, Pedersen NL. Personality and major depression: a Swedish longitudinal, population-based twin study. Arch Gen Psychiatry. 2006;63(10):1113-20.
34. Fogel J, Eaton WW, Ford DE. Minor depression as a predictor of the first onset of major depressive disorder over a 15-year follow-up. Acta Psychiatr Scand. 2006;113(1):36-43.
35. Goodwin RD, Fergusson DM, Horwood LJ. Panic attacks and the risk of depression among young adults in the community. Psychother Psychosom. 2004;73(3):158-65.
36. Breslau N, Lipton RB, Stewart WF, Schultz LR, Welch KM. Comorbidity of migraine and depression: investigating potential etiology and prognosis. Neurology. 2003;60(8):1308-12.
37. Haro JM, Palacin C, Vilagut G, Martinez M, Bernal M, Luque I, et al. Prevalencia de los trastornos mentales y factores asociados: resultados del estudio ESEMeD-Espana. Med Clin (Barc). 2006;126(12):445-51.
38. Melchior M, Chastang JF, Head J, Goldberg M, Zins M, Nabi H, et al. Socioeconomic position predicts long-term depression trajectory: a 13-year follow-up of the GAZEL cohort study. Mol Psychiatry. 2013;18(1):112–21.
39. Turner RJ, Lloyd DA. Stress burden and the lifetime incidence of psychiatric disorder in young adults: racial and ethnic contrasts. Arch Gen Psychiatry. 2004;61(5):481-8.
40. Beck AT. The evolution of the cognitive model of depression and its neurobiological correlates. Am J Psychiatry. 2008;165(8):969-77.
41. De Raedt R, Koster EH. Understanding vulnerability for depression from a cognitive neuroscience perspective: A reappraisal of attentional factors and a new conceptual framework. Cogn Affect Behav Neurosci. 2010;10(1):50-70.
42. Weissman MM, Wickramaratne P, Nomura Y, Warner V, Pilowsky D, Verdeli H. Offspring of depressed parents: 20 years later. Am J Psychiatry. 2006;163(6):1001-8.
43. Sullivan PF, Neale MC, Kendler KS. Genetic epidemiology of major depression: review and meta-analysis. Am J Psychiatry. 2000;157(10):1552-62.
44. Weissman MM, Wickramaratne P, Nomura Y, Warner V, Verdeli H, Pilowsky DJ, et al. Families at high and low risk for depression: a 3-generation study. Arch Gen Psychiatry. 2005;62(1):29- 36.
45. Lieb R IB, Hofler M, Pfister H, Wittchen H. Parenteral major depression and the risk of depression and other mental disorders in offspring: a prospective-longitudinal community study. Arch Gen Psychiatry. 2002;59:365-74.
46. Cervilla JA, Rivera M, Molina E, Torres-Gonzalez F, Bellon JA, Moreno B, et al. The 5-HTTLPR s/s genotype at the serotonin transporter gene (SLC6A4) increases the risk for depression in a large cohort of primary care attendees: the PREDICT-gene study. Am J Med Genet B Neuropsychiatr Genet. 2006;141(8):912-7.
47. Porcelli S, Fabbri C, Serretti A. Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with antidepressant efficacy. Eur Neuropsychopharmacol. 2012;22(4):239-58.
48. King M, Walker C, Levy G, Bottomley C, Royston P, Weich S, et al. Development and validation of an international risk prediction algorithm for episodes of major depression in general practice attendees: the PredictD study. Arch Gen Psychiatry. 2008;65(12):1368-76.
49. Bellón JA, Conejo-Cerón S, Moreno-Peral P, King M, Nazareth I, Martín-Pérez C, et al. Preventing the onset of major depression based on the level and profile of risk of primary care attendees: protocol of a cluster randomised trial (the predictD-CCRT study). BMC Psychiatry. 2013;13(1):171.
50. Hawton K, Saunders K, Topiwala A, Haw C. Psychiatric disorders in patients presenting to hospital following self-harm: a systematic review. J Affect Disord. 2013;151(3):821-30.
51. Grupo de Trabajo de la Guía de Práctica Clínica de Prevención y Tratamiento de la Conducta Suicida. Guía de Práctica Clínica de Prevención y Tratamiento de la Conducta Suicida. Santiago de Compostela: Agencia de Evaluación de Tecnologías Sanitarias de Galicia (avalia-t); 2012. Guías de Práctica Clínica en el SNS: avalia-t Nº 2010/02.
52. Sokero TP, Melartin TK, Rytsälä HJ, Leskelä US, Lestelä-Mielonen PS, Isometsä ET. Prospective study of risk factors for attempted suicide among patients with DSM-IV major depressive disorder. Br J Psychiatry. 2005;186:314-8.
53. Hawton K, Casañas I, Comabella C, Haw C, Saunders K. Risk factors for suicide in individuals with depression: a systematic review. J Affect Disord. 2013;147(1-3):17-28.
54. Dumais A, Lesage AD, Alda M, Rouleau G, Dumont M, Chawky N, et al. Risk factors for suicide completion in major depression: a case-control study of impulsive and aggressive behaviors in men. Am J Psychiatry. 2005;162(11):2116-24.
55. Reed GM, J. M-C, Esparza P, Saxena S, Maj M. The WPA-WHO Global Survey of Psychiatrists’ Attitudes Towards Mental Disorders Classification. World Psychiatry. 2011;10(2):118-31.
56. Organización Mundial de la Salud. Décima Revisión de la Clasificación Internacional de Enfermedades. CIE-10. Trastornos mentales y del comportamiento. Madrid: Meditor; 1992.
57. American Psychiatric Association. Diagnostic and statistical manual of mental disorders : DSM-5. Arlington (VA): American Psychiatric Association; 2013.
58. Alderson SL, Foy R, Glidewell L, McLintock K, House A. How patients understand depression associated with chronic physical disease – a systematic review. BMC Fam Pract. 2012;28(13):41.
59. Schomerus G, Matschinger H, Angermeyer MC. Attitudes that determine willingness to seek psychiatric help for depression: a representative population survey applying the Theory of Planned Behaviour. Psychol Med. 2009;39(11):1855-65.
60. Chakrabarti S, Grover S, Rajagopal R. Electroconvulsive therapy: a review of knowledge, experience and attitudes of patients concerning the treatment. World J Biol Psychiatry. 2010;11(3):525-37.
61. Johansson EE, Bengs C, Danielsson U, Lehti A, Hammarstrom A. Gaps between patients, media, and academic medicine in discourses on gender and depression: A metasynthesis. Qual Health Res. 2009;19(5):633-44.
62. Triñanes Pego Y, Rial Boubeta A, Álvarez Ariza M, de las Heras Liñero E, Atienza Merino G. ¿Cómo mejorar la práctica clínica de la depresión?: una aproximación cualitativa. Santiago de Compostela: Axencia de Avaliación de Tecnoloxías Sanitarias de Galicia (avalia-t); Madrid: Ministerio de Sanidad, Servicios Sociales e Igualdad; de próxima aparición.
63. Coventry PA, Hays R, Dickens C, Bundy C, Garrett C, Cherrington A, et al. Talking about depression: a qualitative study of barriers to managing depression in people with long term conditions in primary care. BMC Family Practice. 2011;12:10.
64. Fu C-M, Parahoo K. Causes of depression: Perceptions among people recovering from depression. J Adv Nurs. 2009;65(1):101-9.
65. Oliffe JL, Ogrodniczuk JS, Bottorff JL, Johnson JL, Hoyak K. “You feel like you can’t live anymore”: suicide from the perspectives of Canadian men who experience depression. Soc Sci Med. 2012;74(4):506-14.
66. Lasch KE, Hassan M, Endicott J, Piault-Luis EC, Locklear J, Fitz-Randolph M, et al. Development and content validity of a patient reported outcomes measure to assess symptoms of major depressive disorder. BMC Psychiatry. 2012;12(34).
67. Ahlstrom BH, Skarsater I, Danielson E. Living with major depression: experiences from families’ perspectives. Scand J Caring Sci. 2009;23(2):309-16.
68. Porr C, Olson K, Hegadoren K. Tiredness, fatigue, and exhaustion in the context of a major depressive disorder. Qual Health Res. 2010;20(10):1315-26.
69. Rice NM, Grealy MA, Javaid A, Millan Serrano R. Understanding the social interaction difficulties of women with unipolar depression. Qual Health Res. 2011;21(10):1388-99.
70. Schofield P, Crosland A, Waheed W, Aseem S, Gask L, Wallace A, et al. Patients’ views of antidepressants: From first experiences to becoming expert. Br J Gen Pract. 2011;61(585):e142-e8.
71. Elwy AR, Yeh J, Worcester J, Eisen SV. An illness perception model of primary care patients’ help seeking for depression. Qual Health Res. 2011;21(11):1495-507.
72. Rochlen AB, Paterniti DA, Epstein RM, Duberstein P, Willeford L, Kravitz RL. Barriers in diagnosing and treating men with depression: a focus group report. Am J Mens Health. 2010;4(2):167-75.
73. Kravitz RL, Paterniti DA, Epstein RM, Rochlen AB, Bell RA, Cipri C, et al. Relational barriers to depression help-seeking in primary care. Patient Educ Couns. 2011;82(2):207-13.
74. Uebelacker LA, Marootian BA, Pirraglia PA, Primack J, Tigue PM, Haggarty R, et al. Barriers and facilitators of treatment for depression in a Latino community: A focus group study. Community Ment Health J. 2012;48(1):114-26.
75. van Geffen ECG, Hermsen JHCM, Heerdink ER, Egberts ACG, Verbeek-Heida PM, van Hulten R. The decision to continue or discontinue treatment: experiences and beliefs of users of selective serotonin-reuptake inhibitors in the initial months–a qualitative study. Res Social Adm Pharm. 2011;7(2):134-50.
76. Epstein RM, Duberstein PR, Feldman MD, Rochlen AB, Bell RA, Kravitz RL, et al. “I didn’t know what was wrong:” how people with undiagnosed depression recognize, name and explain their distress. J Gen Intern Med. 2010;25(9):954-61.
77. Calderón Gómez C, Retolaza Balsategui A, Payo Gordon J, Bacigalupe de la Hera A, Zallo Atxutegi E, Mosquera Metcalfe I. Perspectivas de los pacientes diagnosticados de depresión y atendidos por médicos de familia y psiquiatras. Aten Primaria. 2012;44(10):595-602.
78. Price J, Cole V, Goodwin GM. Emotional side-effects of selective serotonin reuptake inhibitors: qualitative study. Br J Psychiatry. 2009;195(3):211-7.
79. Pohjanoksa-Mantyla M, Saari JK, Narhi U, Karjalainen A, Pylkkanen K, Airaksinen MS, et al. How and why do people with depression access and utilize online drug information: A qualitative study. J Affect Disord. 2009;114(1-3):333-9.
80. Smith M, Vogler J, Zarrouf F, Sheaves C, Jesse J. Electroconvulsive therapy: the struggles in the decision-making process and the aftermath of treatment. Issues Ment Health Nurs. 2009;30(9):554-9.
81. Oliffe JL, Kelly MT, Bottorff JL, Johnson JL, Wong ST. “He’s more typically female because he’s not afraid to cry”: Connecting heterosexual gender relations and men’s depression. Soc Sci Med. 2011;73(5):775-82.
82. Griffiths KM, Crisp DA, Barney L, Reid R. Seeking help for depression from family and friends: a qualitative analysis of perceived advantages and disadvantages. BMC Psychiatry. 2011;11:196.
83. Ahlstrom BH, Skarsater I, Danielson E. The meaning of major depression in family life: the viewpoint of the ill parent. J Clin Nurs. 2010;19(1-2):284-93.
84. Beautrais AL, Collings SCD, Ehrhardt P. Suicide Prevention: A review of evidence of risk and protective factors, and points of effective intervention. Wellington: Ministry of Health. 2005.
85. Hawton K, van Heeringen K. Suicide. Lancet. 2009;373(9672):1372-81.
86. Barley EA, Murray J, Walters P, Tylee A. Managing depression in primary care: A metasynthesis of qualitative and quantitative research from the UK to identify barriers and facilitators. BMC Fam Pract. 2011;12(47).
87. Leydon GM, Dowrick CF, McBride AS, Burgess HJ, Howe AC, Clarke PD, et al. Questionnaire severity measures for depression: a threat to the doctor-patient relationship? Br J Gen Pract. 2011;61(583):117-23.
88. Muñiz J, Fernández-Hermida JR. La opinión de los psicólogos españoles sobre el uso de los tests. Papeles del Psicólogo. 2010;31(1):108-21.
89. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:561-71.
90. Beck AT, Rush AJ, Shaw BF, Emery G. Cognitive therapy of depression New York: Guilford Press; 1979.
91. Beck AT, Steer RA, Brown GK. BDI-II. Beck Depression Inventory-Second Edition manual. San Antonio, TX: The Psychological Corporation; 1996.
92. Sanz J, Navarro ME, Vázquez C. Adaptación española del Inventario para la Depresión de Beck G (BDI-II): 1. Propiedades psicométricas en estudiantes universitarios. Análisis y Modificación de Conducta. 2003;29(124):239-88.
93. Sanz J, Perdigón LA, Vázquez C. Adaptación española del Inventario para la Depresión de Beck G (BDI-II): 2. Propiedades psicométricas en población general. Clínica y Salud. 2003;14(3):249-80.
94. Sanz J, García-Vera MP, Espinosa R, Fortún M, Vázquez C. Adaptación española del Inventario para la Depresión de Beck G (BDI-II): 3. Propiedades psicométricas en pacientes con trastornos psicológicos. Clínica y Salud. 2005;16(2):121-42.
95. Sanz J, García-Vera MP. Rendimiento diagnóstico y estructura factorial del Inventario de Depresión de Beck-II (BDI-II). Anal Psicol. 2013;29(1):66-75.
96. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23:56-62.
97. Hamilton M. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol. 1967;6(4):278-96.
98. Miller IW, Bishop S, Norman WH, Maddever H. The Modified Hamilton Rating Scale for Depression: reliability and validity. Psychiatry Res. 1985;14(2):131-42.
99. Bech P, Allerup P, Gram LF, Reisby N, Rosenberg R, Jacobsen O, et al. The Hamilton depression scale. Evaluation of objectivity using logistic models. Acta Psychiatr Scand. 1981;63(3):290-9.
100. Ramos-Brieva J, Cordero Villafafila A. Validación de la versión castellana de la escala. Hamilton para la depresión. Actas Luso Esp Neurol Psiquiatr Cienc Afines. 1986;14:324-34.
101. Bobes J, Bulbena A, Luque A, Dal-Ré R, Ballesteros J, Ibarra N. Evaluación psicométrica comparativa de las versiones en español de 6, 17 y 21 ítems de la Escala de valoración de Hamilton para la evaluación de la depresión. Med Clin (Barc). 2003;120(18):693-700.
102. Shelton RC. Management of Major Depressive Disorder Following Failure of First Antidepressant Treatment. Prim Psychiatry. 2006;13(4):73-82.
103. Bobes J, Portilla M, Bascarán MD, Saiz P, Bousoño M. Banco de instrumentos básicos para la práctica de la psiquiatría clínica En: Instrumentos de evaluación para los trastornos del humor. 3 ed. Barcelona: Ars Medica; 2004. p. 53-7.
104. Montgomery SA, Asberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry. 1979;134:382-9.
105. Cunningham JL, Wernroth L, von Knorring L, Berglund L, Ekselius L. Agreement between physicians’ and patients’ ratings on the Montgomery-Åsberg Depression Rating Scale. J Affect Disord. 2011;135(1-3):148-53.
106. Lobo A, Chamorro L, Luque A, Dal-Re R, Badia X, Baro E. Validación de las versiones en español de la Montgomery-Asberg Depression Rating Scale y la Hamilton Anxiety Rating Scale para la evaluación de la depresión y de la ansiedad. Med Clin (Barc). 2002;118(13):493-9.
107. Kroenke K, Spitzer RL, Williams JBW. The PHQ-9. Validity of a brief depression severity measure. J Gen Intern Med. 2001;16:606–13.
108. Diez-Quevedo C, Rangil T, Sanchez-Planell L, Kroenke K, Spitzer RL. Validation and utility of the patient health questionnaire in diagnosing mental disorders in 1003 general hospital Spanish inpatients. Psychosom Med. 2001;63(4):679-86.
109. Whooley MA, Avins AL, Miranda J, Browner WS. Case-finding instruments for depression. Two questions are as good as many. J Gen Intern Med. 1997;12(7):439-45.
110. U.S. Preventive Services Task Force. Screening for Depression in Adults. Recommendation Statement. Rockville (MD): AHRQ; 2009 [citado 10 oct 2013]. Disponible en: http://www. uspreventiveservicestaskforce.org/uspstf09/adultdepression/addeprrs.htm
111. Zung WW. A self-rating depression scale. Arch Gen Psychiatry. 1965;12:63–70.
112. Conde V, Escribá JA, Izquierdo J. Evaluación estadística y adaptación castellana de la escala autoaplicada para la depresión de Zung. Arch Neurobiol. 1970;33:185-206.
113. Aragonès Benaiges E, Masdèu Montalà RM, Cando Guasch G, Coll Borràs G. [Diagnostic validity of Zung’s self-rating depression scale on primary care patients]. Actas Esp Psiquiatr. 2001;29(5):310-6.
114. Radloff LS. The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Measure. 1977;1:385–401.
115. Soler J, Pérez-Sola V, Puigdemont D, Pérez-Blanco J, Figueres M, Álvarez E. Estudio de validación del Center for Epidemiologic Studies-Depression (CES-D) en una población española de pacientes con trastornos afectivos. Actas Esp Psiquiatr. 1997;25:243-9.
116. Vázquez FL, Blanco V, López M. An adaptation of the Center for Epidemiologic Studies Depression Scale for use in non-psychiatric Spanish populations. Psychiatry Research. 2007;149:247-52.
117. Druss BG, Hoff RA, Rosenheck RA. Underuse of antidepressants in major depression: prevalence and correlates in a national sample of young adults. J Clin Psychiatry. 2000;61(3):234- 7; quiz 8-9.
118. Lecrubier Y. Is depression under-recognised and undertreated? Int Clin Psychopharmacol. 1998;13 Suppl 5:S3-6.
119. Canadian Task Force on Preventive Health Care. Recommendations on screening for depression in adults. CMAJ. 2013;185(9):775-82.
120. Romera I, Montejo ÁL, Aragonés E, Arbesú JÁ, Iglesias-García C, López S, et al. Systematic depression screening in high-risk patients attending primary care: a pragmatic clusterrandomized trial. BMC Psychiatry. 2013;13(83).
121. Calderón C, Mosquera I, Balagué L, Retolaza A, Bacigalupe A, Belaunzaran J, et al. Modelos e intervenciones de colaboración entre Atención Primaria y Salud Mental en la atención a los pacientes diagnosticados de depresión: resultados de una meta-revisión. Investigación Comisionada. Vitoria-Gasteiz: Departamento de Salud, Gobierno Vasco; 2013. Informe N.º: D-13-13.
122. Bower P, Gilbody S. Stepped care in psychological therapies: access, effectiveness and efficiency: narrative literature review. Br J Psychiatry. 2005;186:11–7.
123. Palao DJ, Pérez-Solà V, Aragonés E, Jódar I. Adaptació al model sanitari català de la guia de pràctica clínica sobre el maneig de la depressió major en l’adult. Barcelona: Departament de Salut. Generalitat de Catalunya, Agència d’Informació, Avaluació i Qualitat en Salut; 2010.
124. Aragonès E, Piñol JL, Caballero A, López-Cortacans G, Casaus P, Hernández JM, et al. Effectiveness of a multi-component programme for managing depression in primary care: a cluster randomized trial. The INDI project. J Affect Disord. 2012;142(1-3):297-305.
125. European Alliance Against Depression [citado 14 ene 2014]. Disponible en: http://www.eaad. net/.
126. Multilevel intervention programme for prevention of depression and suicide. The EAAD experience in Catalonia, Spain [citado 14 ene 2014]. Disponible en: https://webgate.ec.europa. eu/sanco_mental_health/public/GOOD_PRACTICE/402/show.html.
127. Gilbody S, Bower P, Fletcher J, Richards D, Sutton AJ. Collaborative care for depression: a cumulative meta-analysis and review of longer-term outcomes. Arch Intern Med. 2006;166:2314-21.
128. Thota AB, Sipe TA, Byard GJ, Zometa CS, Hahn RA, McKnight-Eily LR, et al. Collaborative care to improve the management of depressive disorders: a community guide systematic review and meta-analysis. Am J Prev Med. 2012;42(5):525-38.
129. Aragonès E, López-Cortacans G, Sánchez-Iriso E, Piñol JL, Caballero A, Salvador-Carulla L, et al. Cost-effectiveness analysis of a collaborative care programme for depression in primary care. J Affect Disord. 2014;159:85-93.
130. European Association for Psychotherapy. Definition of the profession of Psychotherapy [citado 20 sep 2013]. Disponible en: http://www.europsyche.org/contents/13219/definition-ofthe- profession-of-psychotherapy
131. Parikh SV, Segal ZV, Grigoriadis S, Ravindran AV, Kennedy SH, Lam RW, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) clinical guidelines for the management of major depressive disorder in adults. II. Psychotherapy alone or in combination with antidepressant medication. J Affect Disord. 2009;117(Suppl 1):S15-25.
132. Cuijpers P, Smit F, Bohlmeijer E, Hollon SD, Andersson G. Efficacy of cognitive-behavioural therapy and other psychological treatments for adult depression: meta-analytic study of publication bias. Br J Psychiatry. 2010;196(3):173-8.
133. Barth J, Munder T, Gerger H, Nuesch E, Trelle S, Znoj H, et al. Comparative efficacy of seven psychotherapeutic interventions for patients with depression: a network meta-analysis. PLoS Med. 2013;10(5):e1001454.
134. Butler AC, Chapman JE, Forman EM, Beck AT. The empirical status of cognitivebehavioral therapy: a review of meta-analyses. Clin Psychol Rev. 2006 26(1):17-31.
135. DeRubeis RJ, Hollon SD, Amsterdam JD, Shelton RC, Young PR, Salomon RM, et al. Cognitive therapy vs medications in the treatment of moderate to severe depression. Arch Gen Psychiatry. 2005;62(4):409-16.
136. Dimidjian S, Hollon SD, Dobson KS, Schmaling KB, Kohlenberg RJ, Addis ME, et al. Randomized trial of behavioral activation, cognitive therapy, and antidepressant medication in the acute treatment of adults with major depression. J Consult Clin Psychol. 2006;74(4):658-70.
137. Hautzinger M, Jong-Meyer R, Treiber R, Rudolf GAE, Thien U. Efficacy of cognitive behavior therapy, pharmacotherapy, and the combination of both in non-melancholic, unipolar depression. Z Klin Psychol. 1996;25(2):130-45.
138. Jakobsen JC, Lindschou Hansen J, Storebo OJ, Simonsen E, Gluud C. The effects of cognitive therapy versus ‘treatment as usual’ in patients with major depressive disorder. PLoS One. 2011;6(8):e22890.
139. Jakobsen JC, Hansen JL, Storebo OJ, Simonsen E, Gluud C. The effects of cognitive therapy versus ‘no intervention’ for major depressive disorder. PLoS One. 2011;6(12):e28299.
140. Jakobsen JC, Hansen JL, Simonsen S, Simonsen E, Gluud C. Effects of cognitive therapy versus interpersonal psychotherapy in patients with major depressive disorder: a systematic review of randomized clinical trials with meta-analyses and trial sequential analyses. Psychol Med. 2012;42(7):1343-57.
141. Feng CY, Chu H, Chen CH, Chang YS, Chen TH, Chou YH, et al. The effect of cognitive behavioral group therapy for depression: a meta-analysis 2000-2010. Worldviews Evid Based Nurs. 2012;9(1):2-17.
142. Hegerl U, Hautzinger M, Mergl R, Kohnen R, Schutze M, Scheunemann W, et al. Effects of pharmacotherapy and psychotherapy in depressed primary-care patients: A randomized, controlled trial including a patients’ choice arm. Int J Neuropsychopharmacol. 2010;13(1):31- 44.
143. Bockting CL, Spinhoven P, Wouters LF, Koeter MW, Schene AH. Long-term effects of preventive cognitive therapy in recurrent depression: A 5.5-year follow-up study. J Clin Psychiatry. 2009;70(12):1621-8.
144. Godfrin K, van Heeringen C. The effects of mindfulness-based cognitive therapy on recurrence of depressive episodes, mental health and quality of life: A randomized controlled study. Behav Res Ther. 2010;48(8):738-46.
145. van Aalderen J, Donders A, Giommi F, Spinhoven P, Barendregt H, Speckens A. The efficacy of mindfulness-based cognitive therapy in recurrent depressed patients with and without a current depressive episode: A randomized controlled trial. Psychol Med. 2012;42(5):989-1001.
146. Segal ZV, Bieling P, Young T, MacQueen G, Cooke R, Martin L, et al. Antidepressant monotherapy vs sequential pharmacotherapy and mindfulness-based cognitive therapy, or placebo, for relapse prophylaxis in recurrent depression. Arch Gen Psychiatry. 2010;67(12):1256-64.
147. Britton WB, Shahar B, Szepsenwol O, Jacobs WJ. Mindfulness-based cognitive therapy improves emotional reactivity to social stress: results from a randomized controlled trial. Behav Ther. 2012;43(2):365-80.
148. Martell CR, Addis ME, Jacobson NS. Depression in context: Strategies for guided action. Nueva York: W. W. Nortonn. 2001.
149. Martell CR, Dimidjian S, Herman-Dunn R. Activación conductual para la depresión: Una guía clínica. Bilbao: Desclée de Brouwer. 2013.
150. Ekers D, Richards D, McMillan D, Bland J, Gilbody S. Behavioural activation delivered by the nonspecialist: Phase II randomised controlled trial. Br J Psychiatry. 2011;198(1):66-72.
151. Cohen S, O’Leary K, Foran H. A randomized clinical trial of a brief, problem-focused couple therapy for depression. Behav Ther. 2010;41(4):433-46.
152. Klerman GL, Weissman MM, Rounsaville BJ, Chevron ES. Interpersonal Psychotherapy of Depression. New York: Basic Books; 1984.
153. Raue PJ, Schulberg HC, Heo M, Klimstra S, Bruce ML. Patients’ depression treatment preferences and initiation, adherence, and outcome: a randomized primary care study. Psychiatr Serv. 2009(3):337-43.
154. Rogers CR. The necessary and sufficient conditions of therapeutic personality change. J Consult Psychol. 1957;21:95–103.
155. Shedler J. The efficacy of psychodynamic psychotherapy. Am Psychol. 2010;65(2):98-109.
156. Rodgers M, Asaria M, Walker S, McMillan D, Lucock M, Harden M, et al. The clinical effectiveness and cost-effectiveness of low-intensity psychological interventions for the secondary prevention of relapse after depression: a systematic review. Health Technol Assess. 2012;16(28):1-129.
157. NHS Improving Access to Psychological Therapies. Good practice guidance on the use of selfhelp materials within IAPT services: NHS Improving Access to Psychological Therapies; 2010.
158. Bennett-Levy J, Richards DA, Farrand P. Low intensity CBT interventions: a revolution in mental health care. En: Bennett-Levy J, Richards DA, Farrand P, et al., editors. Oxford guide to low intensity CBT interventions. Oxford: Oxford University Press; 2010.
159. Kessler D, Lewis G, Kaur S, Wiles N, King M, Weich S, et al. Therapist-delivered Internet psychotherapy for depression in primary care: a randomised controlled trial. Lancet. 2009;374(9690):628-34.
160. Vernmark K, Lenndin J, Bjarehed J, Carlsson M, Karlsson J, Oberg J, et al. Internet administered guided self-help versus individualized e-mail therapy: A randomized trial of two versions of CBT for major depression. Behav Res Ther. 2010;48(5):368-76.
161. Warmerdam L, van Straten A, Jongsma J, Twisk J, Cuijpers P. Online cognitive behavioral therapy and problem-solving therapy for depressive symptoms: Exploring mechanisms of change. J Behav Ther Exp Psychiatry. 2010;41(1):64-70.
162. Johansson R, Sjoberg E, Sjogren M, Johnsson E, Carlbring P, Andersson T, et al. Tailored vs. standardized internet-based cognitive behavior therapy for depression and comorbid symptoms: a randomized controlled trial. PLoS One. 2012;7(5):e36905.
163. Titov N, Andrews G, Davies M, McIntyre K, Robinson E, Solley K. Internet treatment for depression: a randomized controlled trial comparing clinician vs. technician assistance. PLoS One. 2010;5(6):e10939.
164. Pittaway S, Cupitt C, Palmer D, Arowobusoye N, Milne R, Holttum S, et al. Comparative, clinical feasibility study of three tools for delivery of cognitive behavioural therapy for mild to moderate depression and anxiety provided on a self-help basis. Ment Health Fam Med. 2010(3):145-54.
165. Johansson R, Ekbladh S, Hebert A, Lindstrom M, Moller S, Petitt E, et al. Psychodynamic guided self-help for adult depression through the internet: a randomised controlled trial. PLoS One. 2012;7(5):e38021.
166. Berger T, Hammerli K, Gubser N, Andersson G, Caspar F. Internet-based treatment of depression: A randomized controlled trial comparing guided with unguided self-help. Cogn Behav Ther. 2011;40(4):251-66.
167. Watkins E, Taylor R, Byng R, Baeyens C, Read R, Pearson K, et al. Guided self-help concreteness training as an intervention for major depression in primary care: A Phase II randomized controlled trial. Psychol Med. 2012;42(7):1359-71.
168. Hollandare F, Johnsson S, Randestad M, Tillfors M, Carlbring P, Andersson G, et al. Randomized trial of Internet-based relapse prevention for partially remitted depression. Acta Psychiatr Scand. 2011;124(4):285-94.
169. Taylor MJ, Freemantle N, Geddes JR, Bhagwagar Z. Early onset of selective serotonin reuptake inhibitor antidepressant action: systematic review and meta-analysis. Arch Gen Psychiatry. 2006;63(11):1217-23.
170. Gartlehner G, Hansen RA, Morgan LC, Thaler K, Lux LJ, Van Noord M, et al. Second- Generation Antidepressants in the Pharmacologic Treatment of Adult Depression. Rockville (MD): Agency for Healthcare Research and Quality (US); 2011. Informe N.º: 12-EHC012-EF Contrato N.º: 2902-2007-10056-I.
171. Taylor D, Paton C, Kapur S. The South London and Maudsley NHS Foundation Trust & Oxleas NHS Foundation Trust. Prescribing guidelines. 10th ed. London: Informa Healthcare; 2009.
172. Anderson IM, Ferrier IN, Baldwin RC, Cowen PJ, Howard L, Lewis G, et al. Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 2000 British Association for Psychopharmacology guidelines. J Psychopharmacol. 2008;22(4):343-96.
173. Lam RW, Kennedy SH, Grigoriadis S, McIntyre RS, Milev R, Ramasubbu R, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) clinical guidelines for the management of major depressive disorder in adults III. Pharmacotherapy. J Affect Disord. 2009;117 Suppl 1:S26-43.
174. Agencia española del medicamento y productos sanitarios. Centro de Información online de Medicamentos de la AEMPS – CIMA [citado 20 nov 2013]. Disponible en: http://www.aemps. gob.es/cima/fichasTecnicas.do?metodo=detalleForm.
175. Angora-Cañego R, Esquinas-Requena JL, Agüera-Ortiz LF. Guía de selección de psicofármacos en el anciano con patología médica concomitante Psicogeriatria. 2012;4(1):1- 19.
176. García-Herrera Pérez Bryan JM, Nogueras Morilla EV, Muñoz Cobos M, Morales Asencio JM. Guía de Práctica Clínica para el tratamiento de la depresión en Atención Primaria. Málaga: Distrito Sanitario Málaga-UGC Salud Mental Hospital Regional Universitario “Carlos Haya”; 2011.
177. Undurraga J, Baldessarini R. Randomized, placebo-controlled trials of antidepressants for acute major depression: Thirty-year meta-analytic review. Neuropsychopharmacology. 2012;37(4):851-64.
178. von Wolff A, Holzel LP, Westphal A, Harter M, Kriston L. Selective serotonin reuptake inhibitors and tricyclic antidepressants in the acute treatment of chronic depression and dysthymia: a systematic review and meta-analysis. J Affect Disord. 2013;144(1-2):7-15.
179. Gartlehner G, Hansen RA, Morgan LC, Thaler K, Lux L, Van Noord M, et al. Comparative benefits and harms of second-generation antidepressants for treating major depressive disorder: an updated meta-analysis. Ann Intern Med. 2011;155(11):772-85.
180. Ou JJ, Xun GL, Wu RR, Li LH, Fang MS, Zhang HG, et al. Efficacy and safety of escitalopram versus citalopram in major depressive disorder: a 6-week, multicenter, randomized, doubleblind, flexible-dose study. Psychopharmacology (Berl). 2011;213(2-3):639-46.
181. Thase ME, Ninan PT, Musgnung JJ, Trivedi MH. Remission with venlafaxine extended release or selective serotonin reuptake inhibitors in depressed patients: A randomized, open-label study. Prim Care Companion J Clin Psychiatry. 2011;13(1):e1-e9.
182. Martinez JM, Katon W, Greist JH, Kroenke K, Thase ME, Meyers AL, et al. A pragmatic 12- week, randomized trial of duloxetine versus generic selective serotonin-reuptake inhibitors in the treatment of adult outpatients in a moderate-to-severe depressive episode. Int Clin Psychopharmacol. 2012;27(1):17-26.
183. Grunebaum MF, Ellis SP, Duan N, Burke AK, Oquendo MA, Mann JJ. Pilot randomized clinical trial of an SSRI vs bupropion: Effects on suicidal behavior, ideation, and mood in major depression. Neuropsychopharmacology. 2012;37(3):697-706.
184. Agencia Española del Medicamento [base de datos en Internet]. Agencia Española del Medicamento.Kastan 100 mg comprimidos de liberación prolongada Ficha técnica o resumen de características del producto. Disponible en:http://www.aemps.gob.es/cima/especialidad.do ?metodo=verPresentaciones&codigo=75554.
185. Tourian KA, Padmanabhan SK, Groark J, Brisard C, Farrington D. Desvenlafaxine 50 and 100 mg/d in the treatment of major depressive disorder: an 8-week, phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group trial and a post hoc pooled analysis of three studies. Clin Ther. 2009;31 Pt 1:1405-23.
186. Soares CN, Thase ME, Clayton A, Guico-Pabia CJ, Focht K, Jiang Q, et al. Desvenlafaxine and escitalopram for the treatment of postmenopausal women with major depressive disorder. Menopause. 2010;17(4):700-11.
187. Rickels K, Montgomery SA, Tourian KA, Guelfi JD, Pitrosky B, Padmanabhan SK, et al. Desvenlafaxine for the prevention of relapse in major depressive disorder: results of a randomized trial. J Clin Psychopharmacol. 2010;30(1):18-24.
188. Grupo de Trabajo de la Guía de Práctica Clínica sobre la Depresión Mayor en la Infancia y en la Adolescencia. Madrid: Ministerio de Sanidad y Política Social; 2009. Guías de Práctica Clínica en el SNS: avalia-t Nº 2007/09.
189. Bupropion, mirtazapine, and reboxetine in the treatment of depression: Executive summary of final report A05-20C, Version 1.1 (30.05.2011). En: Institute for Quality and Efficiency in Health Care: Executive Summaries. Cologne: IQWiG; 2011.
190. Eyding D, Lelgemann M, Grouven U, Härter M, Kromp M, Kaiser T, et al. Reboxetine for acute treatment of major depression: systematic review and meta-analysis of published and unpublished placebo and selective serotonin reuptake inhibitor controlled trials. BMJ. 2010;341(c4737).
191. Cipriani A, Furukawa TA, Salanti G, Geddes JR, Higgins JP, Churchill R, et al. Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments metaanalysis. Lancet. 2009;373(9665):746-58.
192. Wiles NJ, Mulligan J, Peters TJ, Cowen PJ, Mason V, Nutt D, et al. Severity of depression and response to antidepressants: GENPOD randomised controlled trial. Br J Psychiatry. 2012;200(2):130-6.
193. Agencia Española del Medicamento [base de datos en Internet]. Agencia Española del Medicamento.Valdoxan 25 mg comprimidos recubiertos con película – NR: 08499003 Ficha técnica o resumen de características del producto. Disponible en: http://www.ema.europa.eu/ docs/es_ES/document_library/EPAR_-_Product_Information/human/000915/WC500046227. pdf.
194. Kennedy SH, Emsley R. Placebo-controlled trial of agomelatine in the treatment of major depressive disorder. Eur Neuropsychopharmacol. 2006;16(2):93-100.
195. Lôo H, Hale A, D’haenen H. Determination of the dose of agomelatine, a melatoninergic agonist and selective 5-HT(2C) antagonist, in the treatment of major depressive disorder: a placebo-controlled dose range study. Int Clin Psychopharmacol. 2002;17(5):239-47.
196. Olie JP, Kasper S. Efficacy of agomelatine, a MT1/MT2 receptor agonist with 5-HT2C antagonistic properties, in major depressive disorder. Int J Neuropsychopharmacol. 2007;10(5):661-73.
197. Stahl SM, Fava M, Trivedi MH, Caputo A, Shah A, Post A. Agomelatine in the treatment of major depressive disorder: an 8-week, multicenter, randomized, placebo-controlled trial. J Clin Psychiatry. 2010;71(5):616-26.
198. Zajecka J, Schatzberg A, Stahl S, Shah A, Caputo A, Post A. Efficacy and safety of agomelatine in the treatment of major depressive disorder: a multicenter, randomized, double-blind, placebo-controlled trial. J Clin Psychopharmacol. 2010;30(2):135-44.
199. Singh SP, Singh V, Kar N. Efficacy of agomelatine in major depressive disorder: metaanalysis and appraisal. Int J Neuropsychopharmacol. 2012;25(3):417-28.
200. Koesters M, Guaiana G, Cipriani A, Becker T, Barbui C. Agomelatine efficacy and acceptability revisited: systematic review and meta-analysis of published and unpublished randomised trials. Br J Psychiatry. 2013;203:179-87.
201. European Agency for the Evaluation of Medicinal Products. CL3-021. Unpublished study, data from EMA reports. En: CHMP Assessment Report for Valdoxan: European Agency for the Evaluation of Medicinal Products; 2008 [citado 10 dic 2013]. Disponible en: http:// www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/ human/000915/WC500046226.pdf
202. European Agency for the Evaluation of Medicinal Products. CL3-022. Unpublished study, data from EMA reports. En: CHMP Assessment Report for Valdoxan: European Agency for the Evaluation of Medicinal Products; 2008 [citado 10 dic 2013]. Disponible en: http:// www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/ human/000915/WC500046226.pdf
203. European Agency for the Evaluation of Medicinal Products. CL3-024. Unpublished study, data from EMA reports. En: CHMP Assessment Report for Valdoxan: European Agency for the Evaluation of Medicinal Products; 2008 [citado 10 dic 2013]. Disponible en: http:// www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/ human/000915/WC500046226.pdf
204. European Agency for the Evaluation of Medicinal Products. CL3-026. Unpublished study, data from EMA reports. En: CHMP Assessment Report for Valdoxan. European Agency for the Evaluation of Medicinal Products 2008 [citado 10 dic 2013]. Disponible en: http:// www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/ human/000915/WC500046226.pdf
205. European Agency for the Evaluation of Medicinal Products. CL3-023. Unpublished study, data from EMA reports. En: CHMP Assessment Report for Valdoxan: European Agency for the Evaluation of Medicinal Products; 2008 [citado 10 dic 2013]. Disponible en: http:// www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/ human/000915/WC500046226.pdf
206. Novartis. CAGO178A2303. Unpublished Study: Novartis; 2011 [citado 10 dic 2013]. Disponible en: http://www.novctrd.com/ctrdWebApp/clinicaltrialrepository/displayFile. do?trialResult=2659
207. Novartis. CAGO178A2304. Unpublished Study: Novartis; 2011 [citado 10 dic 2013]. Disponible en: http://www.novctrd.com/ctrdWebApp/clinicaltrialrepository/displayFile. do?trialResult=3420
208. Goodwin GM, Emsley R, Rembry S, Rouillon F. Agomelatine prevents relapse in patients with major depressive disorder without evidence of a discontinuation syndrome: a 24-week randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2009;70(8):1128-37.
209. Goodwin GM, Boyer P, msley R RF, de Bodinat C. Is it time to shift to better characterization of patients in trials assessing novel antidepressants? An example of two relapse prevention studies with agomelatine. Int Clin Psychopharmacol. 2013;28(1):20-8.
210. Hale A, Corral RM, Mencacci C, Ruiz JS, Severo CA, Gentil V. Superior antidepressant efficacy results of agomelatine versus fluoxetine in severe MDD patients: a randomized, double-blind study. Int Clin Psychopharmacol. 2010;25(6):305-14.
211. Kasper S, Hajak G, Wulff K, Hoogendijk WJ, Montejo AL, Smeraldi E, et al. Efficacy of the novel antidepressant agomelatine on the circadian rest-activity cycle and depressive and anxiety symptoms in patients with major depressive disorder: a randomized, double-blind comparison with sertraline. J Clin Psychiatry. 2010 71(2):109-20.
212. Kennedy SH, Rizvi S, Fulton K, Rasmussen J. A double-blind comparison of sexual functioning, antidepressant efficacy, and tolerability between agomelatine and venlafaxine XR. J Clin Psychopharmacol. 2008;28(3):329-33.
213. Lemoine P, Guilleminault C, Alvarez E. Improvement in subjective sleep in major depressive disorder with a novel antidepressant, agomelatine: randomized, double-blind comparison with venlafaxine. J Clin Psychiatry. 2007;68(11):1723-32.
214. Kasper S, Corruble E, Hale A, Lemoine P, Montgomery SA, Quera-Salva MA. Antidepressant efficacy of agomelatine versus SSRI/SNRI: results from a pooled analysis of head-to-head studies without a placebo control. Int Clin Psychopharmacol. 2013;28(1):12-9.
215. Quera-Salva MA, Hajak G, Philip P, Montplaisir J, Keufer-Le Gall S, Laredo J, et al. Comparison of agomelatine and escitalopram on nighttime sleep and daytime condition and efficacy in major depressive disorder patients. Int Clin Psychopharmacol. 2011;26(5):252-62.
216. Martinotti G, Sepede G, Gambi F, Di Iorio G, De Berardis D, Di Nicola M, et al. Agomelatine versus venlafaxine XR in the treatment of anhedonia in major depressive disorder: a pilot study. J Clin Psychopharmacol. 2012;32(4):487-91.
217. Laux G. The antidepressant agomelatine in daily practice: results of the non-interventional study VIVALDI. Pharmacopsychiatry. 2012;45(7):284-91.
218. Howland RH. A benefit-risk assessment of agomelatine in the treatment of major depression. Drug Saf. 2011;34(9):709-31.
219. Montgomery SA, Kennedy SH, Burrows GD, Lejoyeux M, Hindmarch I. Absence of discontinuation symptoms with agomelatine and occurrence of discontinuation symptoms with paroxetine: a randomized, double-blind, placebo-controlled discontinuation study. Int Clin Psychopharmacol. 2004;19(5):271-80.
220. Informe mensual. Noviembre 2012. Medicamentos de uso humano Madrid: Agencia Española de Medicamentos y Productos Sanitarios; [citado 08 feb 2013]. Disponible en: http://www. aemps.gob.es/informa/informeMensual/2012/noviembre/informe-medicamentos.htm#p3
221. Geddes JR, Carney SM, Davies C, Furukawa TA, Kupfer DJ, Frank E, et al. Relapse prevention with antidepressant drug treatment in depressive disorders: a systematic review. Lancet. 2003;361(9358):653-61.
222. Hansen R, Gaynes B, Thieda P, Gartlehner G, Deveaugh-Geiss A, Krebs E, et al. Meta-analysis of major depressive disorder relapse and recurrence with second-generation antidepressants. Psychiatr Serv. 2008;59(10):1121-30.
223. Reimherr FW, Amsterdam JD, Quitkin FM, Rosenbaum JF, Fava M, Zajecka J, et al. Optimal length of continuation therapy in depression: a prospective assessment during long-term fluoxetine treatment. Am J Psychiatry. 1998;155(9):1247-53.
224. Viguera AC, Baldessarini RJ, Friedberg J. Discontinuing antidepressant treatment in major depression. Harv Rev Psychiatry. 1998;5(6):293-306.
225. Ellis P. Australian and New Zealand clinical practice guidelines for the treatment of depression. Aust N Z J Psychiatry. 2004;38(6):389-407.
226. Papakostas GI, Perlis RH, Seifert C, Fava M. Antidepressant dose reduction and the risk of relapse in major depressive disorder. Psychother Psychosom. 2007;76(5):266-70.
227. Kennedy SH, Lam RW, Parikh SV, Patten SB, Ravindran AV. Canadian Network for Mood and Anxiety Treatments (CANMAT). Clinical guidelines for the management of major depressive disorder in adults. Introduction. J Affect Disord. 2009;117 Suppl 1:S1-2.
228. Serna MC, Cruz I, Real J, Gascó E, Galván L. Duration and adherence of antidepressant treatment (2003 to 2007) based on prescription database. Europe Psychiatry. 2010;25(4): 206– 13.
229. Warner CH, Bobo W, Warner C, Reid S, Rachal J. Antidepressant discontinuation syndrome. Am Fam Physician. 2006;74(3):449-56.
230. Shelton RC, Osuntokun O, Heinloth AN, Corya SA. Therapeutic options for treatmentresistant depression. CNS Drugs. 2010;24(2):131-61.
231. Trivedi RB, Nieuwsma JA, Williams JW, Jr. Examination of the utility of psychotherapy for patients with treatment resistant depression: a systematic review. J Gen Intern Med. 2011;26(6):643-50.
232. Wiles NJ, Hollinghurst S, Mason V, Musa M, Burt V, Hyde J, et al. A randomized controlled trial of cognitive behavioural therapy as an adjunct to pharmacotherapy in primary care based patients with treatment resistant depression: A pilot study. Behav Cogn Psychother. 2008;36(1):21-33.
233. Thase ME, Friedman ES, Biggs MM, Wisniewski SR, Trivedi MH, Luther JF, et al. Cognitive therapy versus medication in augmentation and switch strategies as second-step treatments: a STAR*D report. Am J Psychiatry. 2007;164(5):739-52.
234. Scott J, Teasdale JD, Paykel ES, Johnson AL, Abbott R, Hayhurst H, et al. Effects of cognitive therapy on psychological symptoms and social functioning in residual depression. Br J Psychiatry. 2000;177:440-6.
235. Harley R, Sprich S, Safren S, Jacobo M, Fava M. Adaptation of dialectical behavior therapy skills training group for treatment-resistant depression. J Nerv Ment Dis. 2008;196(2):136-43.
236. Kennedy SH, Segal ZV, Cohen NL, Levitan RD, Gemar M, Bagby RM. Lithium carbonate versus cognitive therapy as sequential combination treatment strategies in partial responders to antidepressant medication: an exploratory trial. J Clin Psychiatry. 2003;64(4):439-44.
237. Blackburn IM, Moore RG. Controlled acute and follow-up trial of cognitive therapy and pharmacotherapy in out-patients with recurrent depression. Br J Psychiatry. 1997;171:328-34.
238. Wiles N, Thomas L, Abel A, Ridgway N, Turner N, Campbell J, et al. Cognitive behavioural therapy as an adjunct to pharmacotherapy for primary care based patients with treatment resistant depression: results of the CoBalT randomised controlled trial. Lancet. 2013;381(9864):375-84.
239. Adli M, Baethge C, Heinz A, Langlitz N, Bauer M. Is dose escalation of antidepressants a rational strategy after a medium-dose treatment has failed? A systematic review. Eur Arch Psychiatry Clin Neurosci. 2005;255(6):387-400.
240. Whitmyer VG, Dunner DL, Kornstein SG, Meyers AL, Mallinckrodt CH, Wohlreich MM, et al. A comparison of initial duloxetine dosing strategies in patients with major depressive disorder. J Clin Psychiatry. 2007;68(12):1921-30.
241. Bose A, Tsai J, Li D. Early non-response in patients with severe depression: escitalopram uptitration versus switch to duloxetine. Clin Drug Investig. 2012;32(6):373-85.
242. Corya SA, Williamson D, Sanger TM, Briggs SD, Case M, Tollefson G. A randomized, double-blind comparison of olanzapine/fluoxetine combination, olanzapine, fluoxetine, and venlafaxine in treatment-resistant depression. Depress Anxiety. 2006;23(6):364-72.
243. Lenox-Smith AJ, Jiang Q. Venlafaxine extended release versus citalopram in patients with depression unresponsive to a selective serotonin reuptake inhibitor. Int Clin Psychopharmacol. 2008;23(3):113-9.
244. Thase ME, Rush AJ, Howland RH, Kornstein SG, Kocsis JH, Gelenberg AJ, et al. Doubleblind switch study of imipramine or sertraline treatment of antidepressant-resistant chronic depression. Arch Gen Psychiatry. 2002;59(3):233-9.
245. Poirier MF, Boyer P. Venlafaxine and paroxetine in treatment-resistant depression. Doubleblind, randomised comparison. Br J Psychiatry. 1999;175:12-6.
246. Baldomero EB, Ubago JG, Cercos CL, Ruiloba JV, Calvo CG, Lopez RP. Venlafaxine extended release versus conventional antidepressants in the remission of depressive disorders after previous antidepressant failure: ARGOS study. Depress Anxiety. 2005;22(2):68-76.
247. Fang Y, Yuan C, Xu Y, Chen J, Wu Z, Cao L, et al. Comparisons of the efficacy and tolerability of extended-release venlafaxine, mirtazapine, and paroxetine in treatment-resistant depression: a double-blind, randomized pilot study in a Chinese population. J Clin Psychopharmacol. 2010;30(4):357-64.
248. Rosso G, Rigardetto S, Bogetto F, Maina G. A randomized, single-blind, comparison of duloxetine with bupropion in the treatment of SSRI-resistant major depression. J Affect Disord. 2012;136(1-2):172-6.
249. Romera I, Perez V, Manuel Menchon J, Schacht A, Papen R, Neuhauser D, et al. Early vs. conventional switching of antidepressants in patients with MDD and moderate to severe pain: A double-blind randomized study. J Affect Disord. 2012;143(1-3):47-55.
250. Souery D, Serretti A, Calati R, Oswald P, Massat I, Konstantinidis A, et al. Citalopram versus desipramine in treatment resistant depression: effect of continuation or switching strategies: a randomized open study. World J Biol Psychiatry. 2011;12(5):364-75.
251. Ferreri M, Lavergne F, Berlin I, Payan C, Puech AJ. Benefits from mianserin augmentation of fluoxetine in patients with major depression non-responders to fluoxetine alone. Acta Psychiatr Scand. 2001;103(1):66-72.
252. Licht RW, Qvitzau S. Treatment strategies in patients with major depression not responding to first-line sertraline treatment. A randomised study of extended duration of treatment, dose increase or mianserin augmentation. Psychopharmacology. 2002;161(2):143-51.
253. Maes M, Libbrecht I, van Hunsel F, Campens D, Meltzer HY. Pindolol and mianserin augment the antidepressant activity of fluoxetine in hospitalized major depressed patients, including those with treatment resistance. J Clin Psychopharmacol. 1999;19(2):177-82.
254. Fava M, Alpert J, Nierenberg A, Lagomasino I, Sonawalla S, Tedlow J, et al. Double-blind study of high-dose fluoxetine versus lithium or desipramine augmentation of fluoxetine in partial responders and nonresponders to fluoxetine. J Clin Psychopharmacol. 2002;22(4):379- 87.
255. Fava M, Rosenbaum JF, McGrath PJ, Stewart JW, Amsterdam JD, Quitkin FM. Lithium and tricyclic augmentation of fluoxetine treatment for resistant major depression: a double-blind, controlled study. Am J Psychiatry. 1994;151(9):1372-4.
256. Carpenter LL, Yasmin S, Price LH. A double-blind, placebo-controlled study of antidepressant augmentation with mirtazapine. Biol Psychiatry. 2002;51(2):183-8.
257. Seguí J, Lopez-Munoz F, Alamo C, Camarasa X, Garcia-Garcia P, Pardo A. Effects of adjunctive reboxetine in patients with duloxetine-resistant depression: a 12-week prospective study. J Psychopharmacol. 2010;24(8):1201-7.
258. Berman RM, Marcus RN, Swanink R, McQuade RD, Carson WH, Corey-Lisle PK, et al. The efficacy and safety of aripiprazole as adjunctive therapy in major depressive disorder: a multicenter, randomized, double-blind, placebo-controlled study. J Clin Psychiatry. 2007;68(6):843-53.
259. Marcus RN, McQuade RD, Carson WH, Hennicken D, Fava M, Simon JS, et al. The efficacy and safety of aripiprazole as adjunctive therapy in major depressive disorder: a second multicenter, randomized, double-blind, placebo-controlled study. J Clin Psychopharmacol. 2008;28(2):156-65.
260. Fava M, Mischoulon D, Iosifescu D, Witte J, Pencina M, Flynn M, et al. A double-blind, placebocontrolled study of aripiprazole adjunctive to antidepressant therapy among depressed outpatients with inadequate response to prior antidepressant therapy (ADAPT-A Study). Psychother Psychosom. 2012;81(2):87-97.
261. Fabrazzo M, Perris F, Monteleone P, Esposito G, Catapano F, Maj M. Aripiprazole augmentation strategy in clomipramine-resistant depressive patients: an open preliminary study. Eur Neuropsychopharmacol. 2012;22(2):132-6.
262. Shelton RC, Williamson DJ, Corya SA, Sanger TM, Van Campen LE, Case M, et al. Olanzapine/ fluoxetine combination for treatment-resistant depression: a controlled study of SSRI and nortriptyline resistance. J Clin Psychiatry. 2005;66(10):1289-97.
263. Thase ME, Corya SA, Osuntokun O, Case M, Henley DB, Sanger TM, et al. A randomized, double-blind comparison of olanzapine/fluoxetine combination, olanzapine, and fluoxetine in treatment-resistant major depressive disorder. J Clin Psychiatry. 2007;68(2):224-36.
264. Trivedi MH, Thase ME, Osuntokun O, Henley DB, Case M, Watson SB, et al. An integrated analysis of olanzapine/fluoxetine combination in clinical trials of treatment-resistant depression. J Clin Psychiatry. 2009;70(3):387-96.
265. Shelton RC, Tollefson GD, Tohen M, Stahl S, Gannon KS, Jacobs TG, et al. A novel augmentation strategy for treating resistant major depression. Am J Psychiatry. 2001;158(1):131-4.
266. Keitner GI, Garlow SJ, Ryan CE, Ninan PT, Solomon DA, Nemeroff CB, et al. A randomized, placebo-controlled trial of risperidone augmentation for patients with difficult-to-treat unipolar, non-psychotic major depression. J Psychiatr Res. 2009;43(3):205-14.
267. Mahmoud RA, Pandina GJ, Turkoz I, Kosik-Gonzalez C, Canuso CM, Kujawa MJ, et al. Risperidone for treatment-refractory major depressive disorder: a randomized trial. Ann Intern Med. 2007;147(9):593-602.
268. Song ZW, Liu XB, Li YD. Venlafaxine combined with low-dose risperidone for treatmentresistant depression. J Clin Rehab Tis Eng Res. 2007;11.
269. Fang Y, Yuan C, Xu Y, Chen J, Wu Z, Cao L, et al. A pilot study of the efficacy and safety of paroxetine augmented with risperidone, valproate, buspirone, trazodone, or thyroid hormone in adult Chinese patients with treatment-resistant major depression. J Clin Psychopharmacol. 2011;31(5):638-42.
270. McIntyre A, Gendron A, McIntyre A. Quetiapine adjunct to selective serotonin reuptake inhibitors or venlafaxine in patients with major depression, comorbid anxiety, and residual depressive symptoms: A randomized, placebo-controlled pilot study. Depress anxiety. 2007;24(7):487-94.
271. Bauer M, El-Khalili N, Datto C, Szamosi J, Eriksson H. A pooled analysis of two randomised, placebo-controlled studies of extended release quetiapine fumarate adjunctive to antidepressant therapy in patients with major depressive disorder. J Affect Disord. 2010;127(1- 3):19-30.
272. Bauer M, Pretorius HW, Constant EL, Earley WR, Szamosi J, Brecher M. Extended-release quetiapine as adjunct to an antidepressant in patients with major depressive disorder: results of a randomized, placebo-controlled, double-blind study. J Clin Psychiatry. 2009;70(4):540-9.
273. El-Khalili N, Joyce M, Atkinson S, Buynak RJ, Datto C, Lindgren P, et al. Extended-release quetiapine fumarate (quetiapine XR) as adjunctive therapy in major depressive disorder (MDD) in patients with an inadequate response to ongoing antidepressant treatment: A multicentre, randomized, double-blind, placebo-controlled study. Int J Neuropsychopharmacol. 2010;13(7):917-32.
274. McIntyre A, Gendron A. Quetiapine adjunct to selective serotonin reuptake inhibitors or venlafaxine in patients with major depression, comorbid anxiety, and residual depressive symptoms: a randomized, placebo-controlled pilot study. Depress anxiety. 2007;24(7):487-94.
275. Doree JP, Des Rosiers J, Lew V, Gendron A, Elie R, Stip E, et al. Quetiapine augmentation of treatment-resistant depression: a comparison with lithium. Current medical research and opinion. 2007;23(2):333-41.
276. Yoshimura R, Ikenouchi-Sugita A, Hori H, Umene-Nakano W, Katsuki A, Hayashi K, et al. Adding a low dose atypical antipsychotic drug to an antidepressant induced a rapid increase of plasma brain-derived neurotrophic factor levels in patients with treatment-resistant depression. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(2):308-12.
277. National Institute for Clinical Excellence (NICE). Depression: management of depression in primary and secondary care. London: National Clinical Practice Guideline number 23; 2004.
278. Nierenberg AA, Fava M, Trivedi MH, Wisniewski SR, Thase ME, McGrath PJ, et al. A comparison of lithium and T(3) augmentation following two failed medication treatments for depression: a STAR*D report. Am J Psychiatry. 2006;163(9):1519-30.
279. Gervasoni N, Aubry JM, Gex-Fabry M, Bertschy G, Bondolfi G. Is there a place for tricyclic antidepressants and subsequent augmentation strategies in obtaining remission for patients with treatment resistant depression? Pharmacol Res. 2009;59(3):202-6.
280. Normann C, Hummel B, Scharer LO, Horn M, Grunze H, Walden J. Lamotrigine as adjunct to paroxetine in acute depression: a placebo-controlled, double-blind study. J Clin Psychiatry. 2002;63(4):337-44.
281. Barbosa L, Berk M, Vorster M. A double-blind, randomized, placebo-controlled trial of augmentation with lamotrigine or placebo in patients concomitantly treated with fluoxetine for resistant major depressive episodes. J Clin Psychiatry. 2003;64(4):403-7.
282. Santos MA, Rocha FL, Hara C. Efficacy and safety of antidepressant augmentation with lamotrigine in patients with treatment-resistant depression: a randomized, placebo-controlled, double-blind study. Prim Care Companion J Clin Psychiatry. 2008;10(3):187-90.
283. Schindler F, Anghelescu IG. Lithium versus lamotrigine augmentation in treatment resistant unipolar depression: a randomized, open-label study. Int Clin Psychopharmacol. 2007;22(3):179-82.
284. Barbee JG, Thompson TR, Jamhour NJ, Stewart JW, Conrad EJ, Reimherr FW, et al. A double-blind placebo-controlled trial of lamotrigine as an antidepressant augmentation agent in treatment-refractory unipolar depression. J Clin Psychiatry. 2011;72(10):1405-12.
285. Mowla A, Kardeh E. Topiramate augmentation in patients with resistant major depressive disorder: a double-blind placebo-controlled clinical trial. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35(4):970-3.
286. Joffe RT, Singer W, Levitt AJ, MacDonald C. A placebo-controlled comparison of lithium and triiodothyronine augmentation of tricyclic antidepressants in unipolar refractory depression. Arch Gen Psychiatry. 1993;50(5):387-93.
287. Siwek M, Dudek D, Paul IA, Sowa-Kucma M, Zieba A, Popik P, et al. Zinc supplementation augments efficacy of imipramine in treatment resistant patients: a double blind, placebocontrolled study. J Affect Disord. 2009;118(1-3):187-95.
288. Kennedy SH, Lam RW, Cohen NL, Ravindran AV. Canadian Network for Mood and Anxiety Treatments (CANMAT). Clinical guidelines for the treatment of depressive disorders. IV. Medications and other biological treatments. Can J Psychiatry. 2001;46 Suppl 1:38S-58S.
289. Rose D, Fleischmann P, Wykes T, Leese M, Bindman J. Patients’ perspectives on electroconvulsive therapy: systematic review. BMJ. 2003;326(7403):1363.
290. Dunne RA, McLoughlin DM. Systematic review and meta-analysis of bifrontal electroconvulsive therapy versus bilateral and unilateral electroconvulsive therapy in depression. World J Biol Psychiatry. 2012;13(4):248-58.
291. National Institute for Health and Clinical Excellence. Antenatal and postnatal mental health: Clinical management and service guidance. London: NICE; 2007.
292. Geddes J, Carney S, Cowen P, Goodwin G, Rogers R, Dearness K, et al. Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis. Lancet. 2003;361(9360):799-808.
293. Navarro V, Gasto C, Torres X, Masana G, Penades R, Guarch J, et al. Continuation/maintenance treatment with nortriptyline versus combined nortriptyline and ECT in late-life psychotic depression: a two-year randomized study. Am J Geriat Psychiat. 2008;16(6):498-505.
294. Kellner CH, Knapp RG, Petrides G, Rummans TA, Husain MM, Rasmussen K, et al. Continuation electroconvulsive therapy vs pharmacotherapy for relapse prevention in major depression: a multisite study from the Consortium for Research in Electroconvulsive Therapy (CORE). Arch Gen Psychiatry. 2006;63(12):1337-44.
295. Grunhaus L, Hirschman S, Dolberg OT, Schreiber S, Dannon PN. Coadministration of melatonin and fluoxetine does not improve the 3-month outcome following ECT. J ECT. 2001;17(2):124-8.
296. Sackeim HA, Haskett RF, Mulsant BH, Thase ME, Mann JJ, Pettinati HM, et al. Continuation pharmacotherapy in the prevention of relapse following electroconvulsive therapy: a randomized controlled trial. JAMA. 2001;285(10):1299-307.
297. Lauritzen L, Odgaard K, Clemmesen L, Lunde M, Ohrstrom J, Black C, et al. Relapse prevention by means of paroxetine in ECT-treated patients with major depression: a comparison with imipramine and placebo in medium-term continuation therapy. Acta Psychiat Scand. 1996;94(4):241-51.
298. van Schaik AM, Comijs HC, Sonnenberg CM, Beekman AT, Sienaert P, Stek ML. Efficacy and safety of continuation and maintenance electroconvulsive therapy in depressed elderly patients: a systematic review. Am J Geriatr Psychiatry. 2012;20(1):5-17.
299. Serra M, Gasto C, Navarro V, Torres X, Blanch J, Masana G. Tratamiento electroconvulsivo de mantenimiento en la depresión unipolar psicótica del anciano. Med Clin (Barc). 2006;126(13):491-2.
300. Ramani R. Vagus nerve stimulation therapy for seizures. J Neurosurg Anesthesiol. 2008;20(1):29-35.
301. Sakas DE, Korfias S, Nicholson CL, Panourias IG, Georgakoulias N, Gatzonis S, et al. Vagus nerve stimulation for intractable epilepsy: outcome in two series combining 90 patients. Acta Neurochir Suppl. 2007;97(Pt 2):287-91.
302. Schachter SC. Vagus nerve stimulation therapy summary: five years after FDA approval. Neurology. 2002;59(6 Suppl 4):S15-20.
303. Elger G, Hoppe C, Falkai P, Rush AJ, Elger CE. Vagus nerve stimulation is associated with mood improvements in epilepsy patients. Epilepsy Res. 2000;42(2-3):203-10.
304. Hoppe C, Helmstaedter C, Scherrmann J, Elger CE. Self-Reported Mood Changes following 6 Months of Vagus Nerve Stimulation in Epilepsy Patients. Epilepsy Behav. 2001;2(4):335-42.
305. Marangell LB, Rush AJ, George MS, Sackeim HA, Johnson CR, Husain MM, et al. Vagus nerve stimulation (VNS) for major depressive episodes: one year outcomes. Biol Psychiatry. 2002;51(4):280-7.
306. Rush AJ, Marangell LB, Sackeim HA, George MS, Brannan SK, Davis SM, et al. Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial. Biological psychiatry. 2005;58(5):347-54.
307. Sackeim HA, Rush AJ, George MS, Marangell LB, Husain MM, Nahas Z, et al. Vagus nerve stimulation (VNS) for treatment-resistant depression: efficacy, side effects, and predictors of outcome. Neuropsychopharmacology. 2001;25(5):713-28.
308. Daban C, Martinez-Aran A, Cruz N, Vieta E. Safety and efficacy of Vagus Nerve Stimulation in treatment-resistant depression. A systematic review. J Affect Disord. 2008;110(1-2):1-15.
309. Martin JL, Martin-Sanchez E. Systematic review and meta-analysis of vagus nerve stimulation in the treatment of depression: variable results based on study designs. Eur Psychiatry. 2012;27(3):147-55.
310. Rush AJ, George MS, Sackeim HA, Marangell LB, Husain MM, Giller C, et al. Vagus nerve stimulation (VNS) for treatment-resistant depressions: a multicenter study. Biol Psychiatry. 2000;47(4):276-86.
311. Armitage R, Husain M, Hoffmann R, Rush AJ. The effects of vagus nerve stimulation on sleep EEG in depression: a preliminary report. J Psychosom Res. 2003;54(5):475-82.
312. Neuhaus AH, Luborzewski A, Rentzsch J, Brakemeier EL, Opgen-Rhein C, Gallinat J, et al. P300 is enhanced in responders to vagus nerve stimulation for treatment of major depressive disorder. J Affect Disord. 2007;100(1-3):123-8.
313. O’Keane V, Dinan TG, Scott L, Corcoran C. Changes in hypothalamic-pituitary-adrenal axis measures after vagus nerve stimulation therapy in chronic depression. Biol Psychiatry. 2005;58(12):963-8.
314. Frick C, Hosten S, Kosel M, Brodeße D, Axmacher N, Kuehn KU, et al. Results of the European multi-centre study (DO3) of vagus nerve stimulation in treatment-resistant depressive patients. Poster presented at the ENCP Congress, Paris, France, 2006, 16–19 September.
315. George MS, Rush AJ, Marangell LB, Sackeim HA, Brannan SK, Davis SM, et al. A oneyear comparison of vagus nerve stimulation with treatment as usual for treatment-resistant depression. Biol Psychiatry. 2005;58(5):364-73.
316. Burke MJ, Husain MM. Concomitant use of vagus nerve stimulation and electroconvulsive therapy for treatment-resistant depression. J Ect. 2006;22(3):218-22.
317. Nahas Z, Marangell LB, Husain MM, Rush AJ, Sackeim HA, Lisanby SH, et al. Two-year outcome of vagus nerve stimulation (VNS) for treatment of major depressive episodes. J Clin Psychiatry. 2005;66(9):1097-104.
318. National Institute for Clinical Excellence (NICE). Intervencional procedures programme. IPG330 Vagus nerve stimulation for treatment-resistant depression. London: NICE; 2009. Disponible en: http://www.nice.org.uk/guidance/IPG330.
319. Nahas Z, Teneback C, Chae JH, Mu Q, Molnar C, Kozel FA, et al. Serial vagus nerve stimulation functional MRI in treatment-resistant depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2007;32(8):1649- 60.
320. Nierenberg AA, Alpert JE, Gardner-Schuster EE, Seay S, Mischoulon D. Vagus nerve stimulation: 2-year outcomes for bipolar versus unipolar treatment-resistant depression. Biol Psychiatry. 2008;64(6):455-60.
321. Sperling W, Reulbach U, Kornhuber J. Clinical benefits and cost effectiveness of vagus nerve stimulation in a long-term treatment of patients with major depression. Pharmacopsychiatry. 2009;42(3):85-8.
322. Franzini A, Messina G, Marras C, Savino M, Miniati M, Bugiani O, et al. Hamilton rating scale for depression-21 modifications in patients with vagal nerve stimulation for treatment of treatment-resistant depression: series report. Neuromodulation. 2008;11(4):267-71.
323. Sackeim HA, Brannan SK, Rush AJ, George MS, Marangell LB, Allen J. Durability of antidepressant response to vagus nerve stimulation (VNS). Int J Neuropsychopharmacol. 2007;10(6):817-26.
324. Schlaepfer TE, Frick C, Zobel A, Maier W, Heuser I, Bajbouj M, et al. Vagus nerve stimulation for depression: efficacy and safety in a European study. Psychol Med. 2008;38(5):651-61.
325. Bajbouj M, Merkl A, Schlaepfer TE, Frick C, Zobel A, Maier W, et al. Two-year outcome of vagus nerve stimulation in treatment-resistant depression. J Clin Psychopharmacol. 2010;30(3):273-81.
326. Marangell LB, Suppes T, Zboyan HA, Prashad SJ, Fischer G, Snow D, et al. A 1-year pilot study of vagus nerve stimulation in treatment-resistant rapid-cycling bipolar disorder. J Clin Psychiatry. 2008;69(2):183-9.
327. Rush AJ, Sackeim HA, Marangell LB, George MS, Brannan SK, Davis SM, et al. Effects of 12 months of vagus nerve stimulation in treatment-resistant depression: a naturalistic study. Biol Psychiatry. 2005;58(5):355-63.
328. Chavel SM, Westerveld M, Spencer S. Long-term outcome of vagus nerve stimulation for refractory partial epilepsy. Epilepsy Behav. 2003;4(3):302-9.
329. Hallbook T, Lundgren J, Stjernqvist K, Blennow G, Stromblad LG, Rosen I. Vagus nerve stimulation in 15 children with therapy resistant epilepsy; its impact on cognition, quality of life, behaviour and mood. Seizure. 2005;14(7):504-13.
330. Harden CL, Pulver MC, Ravdin LD, Nikolov B, Halper JP, Labar DR. A Pilot Study of Mood in Epilepsy Patients Treated with Vagus Nerve Stimulation. Epilepsy Behav. 2000;1(2):93-9.
331. McGlone J, Valdivia I, Penner M, Williams J, Sadler RM, Clarke DB. Quality of life and memory after vagus nerve stimulator implantation for epilepsy. Can J Neurol Sci. 2008;35(3):287-96.
332. Martin JL, Barbanoj MJ, Schlaepfer TE, Clos S, Perez V, Kulisevsky J, et al. Transcranial magnetic stimulation for treating depression. Cochrane Database Syst Rev. 2002(2):CD003493.
333. Herrmann LL, Ebmeier KP. Factors modifying the efficacy of transcranial magnetic stimulation in the treatment of depression: a review. J Clin Psychiatry. 2006;67(12):1870-6.
334. National Institute for Clinical Excellence (NICE). Intervencional procedures programme. IPG242 Transcranial magnetic stimulation for severe depression London: NICE; 2007. Disponible en: http://www.nice.org.uk/guidance/IPG242.
335. Avery DH, Holtzheimer PE, 3rd, Fawaz W, Russo J, Neumaier J, Dunner DL, et al. A controlled study of repetitive transcranial magnetic stimulation in medication-resistant major depression. Biol Psychiatry. 2006;59(2):187-94.
336. Dannon PN, Dolberg OT, Schreiber S, Grunhaus L. Three and six-month outcome following courses of either ECT or rTMS in a population of severely depressed individuals–preliminary report. Biol Psychiatry. 2002;51(8):687-90.
337. Fitzgerald PB, Brown TL, Marston NA, Daskalakis ZJ, De Castella A, Kulkarni J. Transcranial magnetic stimulation in the treatment of depression: a double-blind, placebo-controlled trial. Arch Gen Psychiatry. 2003;60(10):1002-8.
338. Koerselman F, Laman DM, van Duijn H, van Duijn MA, Willems MA. A 3-month, followup, randomized, placebo-controlled study of repetitive transcranial magnetic stimulation in depression. J Clin Psychiatry. 2004;65(10):1323-8.
339. McDonald WM, Easley K, Byrd EH, Holtzheimer P, Tuohy S, Woodard JL, et al. Combination rapid transcranial magnetic stimulation in treatment refractory depression. Neuropsychiatr Dis Treat. 2006;2(1):85-94.
340. Rossini D, Lucca A, Zanardi R, Magri L, Smeraldi E. Transcranial magnetic stimulation in treatment-resistant depressed patients: a double-blind, placebo-controlled trial. Psychiatry Res. 2005;137(1-2):1-10.
341. Rossini D, Magri L, Lucca A, Giordani S, Smeraldi E, Zanardi R. Does rTMS hasten the response to escitalopram, sertraline, or venlafaxine in patients with major depressive disorder? A double-blind, randomized, sham-controlled trial. J Clin Psychiatry. 2005;66(12):1569-75.
342. Machii K, Cohen D, Ramos-Estebanez C, Pascual-Leone A. Safety of rTMS to non-motor cortical areas in healthy participants and patients. Clin Neurophysiol. 2006;117(2):455-71.
343. Slotema CW, Blom JD, Hoek HW, Sommer IE. Should we expand the toolbox of psychiatric treatment methods to include Repetitive Transcranial Magnetic Stimulation (rTMS)? A metaanalysis of the efficacy of rTMS in psychiatric disorders. J Clin Psychiatry. 2010;71(7):873-84.
344. Brunoni AR, Fregni F. Clinical trial design in non-invasive brain stimulation psychiatric research. Int J Methods Psychiatr Res. 2011;20(2):e19-30.
345. Loo CK, Mitchell PB. A review of the efficacy of transcranial magnetic stimulation (TMS) treatment for depression, and current and future strategies to optimize efficacy. J Affect Disord. 2005;88(3):255-67.
346. Ridding MC, Rothwell JC. Is there a future for therapeutic use of transcranial magnetic stimulation? Nat Rev Neurosci. 2007;8(7):559-67.
347. George MS, Lisanby SH, Avery D, McDonald WM, Durkalski V, Pavlicova M, et al. Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder: a shamcontrolled randomized trial. Arch Gen Psychiatry. 2010;67(5):507-16.
348. Bretlau LG, Lunde M, Lindberg L, Unden M, Dissing S, Bech P. Repetitive transcranial magnetic stimulation (rTMS) in combination with escitalopram in patients with treatment-resistant major depression: a double-blind, randomised, sham-controlled trial. Pharmacopsychiatry. 2008;41(2):41-7.
349. Blumberger DM, Mulsant BH, Fitzgerald PB, Rajji TK, Ravindran AV, Young LT, et al. A randomized double-blind sham-controlled comparison of unilateral and bilateral repetitive transcranial magnetic stimulation for treatment-resistant major depression. World J Biol Psychiatry. 2012;13(6):423-35.
350. Dell’Osso B, Mundo E, D’Urso N, Pozzoli S, Buoli M, Ciabatti M, et al. Augmentative repetitive navigated transcranial magnetic stimulation (rTMS) in drug-resistant bipolar depression. Bipolar Disord. 2009;11(1):76-81.
351. Hadley D, Anderson BS, Borckardt JJ, Arana A, Li X, Nahas Z, et al. Safety, tolerability, and effectiveness of high doses of adjunctive daily left prefrontal repetitive transcranial magnetic stimulation for treatment-resistant depression in a clinical setting. J Ect. 2011;27(1):18-25.
352. Jhanwar VG, Bishnoi RJ, Singh L, Jhanwar MR. Utility of repetitive transcranial magnetic stimulation as an augmenting treatment method in treatment-resistant depression. Indian J Psychiatry. 2011;53(2):145-8.
353. Berlim MT, Van den Eynde F, Daskalakis ZJ. Efficacy and acceptability of high frequency repetitive transcranial magnetic stimulation (rTMS) versus electroconvulsive therapy (ECT) for major depresion: a systematic review and meta-analysis of randomized trials. Depress Anxiety. 2013;00:1-10.
354. Eranti S, Mogg A, Pluck G, Landau S, Purvis R, Brown RG, et al. A randomized, controlled trial with 6-month follow-up of repetitive transcranial magnetic stimulation and electroconvulsive therapy for severe depression. Am J Psychiatry. 2007;164(1):73-81.
355. Grunhaus L, Dannon PN, Schreiber S, Dolberg OH, Amiaz R, Ziv R, et al. Repetitive transcranial magnetic stimulation is as effective as electroconvulsive therapy in the treatment of nondelusional major depressive disorder: an open study. Biol Psychiatry. 2000;47(4):314-24.
356. Grunhaus L, Schreiber S, Dolberg OT, Polak D, Dannon PN. A randomized controlled comparison of electroconvulsive therapy and repetitive transcranial magnetic stimulation in severe and resistant nonpsychotic major depression. Biol Psychiatry. 2003;53(4):324-31.
357. Janicak PG, Dowd SM, Martis B, Alam D, Beedle D, Krasuski J, et al. Repetitive transcranial magnetic stimulation versus electroconvulsive therapy for major depression: preliminary results of a randomized trial. Biol Psychiatry. 2002;51(8):659-67.
358. Keshtkar M, Ghanizadeh A, Firoozabadi A. Repetitive transcranial magnetic stimulation versus electroconvulsive therapy for the treatment of major depressive disorder, a randomized controlled clinical trial. J Ect. 2011;27(4):310-4.
359. Pridmore S, Bruno R, Turnier-Shea Y, Reid P, Rybak M. Comparison of unlimited numbers of rapid transcranial magnetic stimulation (rTMS) and ECT treatment sessions in major depressive episode. Int J Neuropsychopharmacol. 2000;3(2):129-34.
360. Rosa MA, Gattaz WF, Pascual-Leone A, Fregni F, Rosa MO, Rumi DO, et al. Comparison of repetitive transcranial magnetic stimulation and electroconvulsive therapy in unipolar nonpsychotic refractory depression: a randomized, single-blind study. Int J Neuropsychopharmacol. 2006;9(6):667-76.
361. Thorén P, Floras JS, Hoffmann P, Seals DR. Endorphins and exercise: physiological mechanisms and clinical implications. Med Sci Sports Exerc. 1990;22(4):417-28.
362. American College of Sports Medicine. Guidelines for Graded Exercise Testing and Exercise Prescription Madison: Wisconsin; 1980.
363. Scottish Intercollegiate Guidelines Network. Non-pharmaceutical management of depression in adults. A national clinical guideline. Edinburgh: Scottish Intercollegiate Guidelines Network; 2010 [citado 2 oct 2013]. Disponible en: http://www.sign.ac.uk/pdf/sign114.pdf
364. Cooney GM, Dwan K, Greig CA, Lawlor DA, Rimer J, Waugh FR, et al. Exercise for depression. Cochrane Database Syst Rev. 2013;12(9):CD004366.
365. World Health Organization. Mental health: Physical activity. Geneva: WHO; 2012 [citado 10 dic 2013]. [aprox. 2 pantallas]. Disponible en: http://www.who.int/mental_health/mhgap
366. Silveira H, Moraes H, Oliveira N, Coutinho ES, Laks J, Deslandes A. Physical exercise and clinically depressed patients: a systematic review and meta-analysis. Neuropsychobiology. 2013;67(2):61-8.
367. Josefsson T, Lindwall M, Archer T. Physical exercise intervention in depressive disorders: Meta-analysis and systematic review. Scand J Med Sci Sports. 2013.
368. Danielsson L, Noras AM, Waern M, Carlsson J. Exercise in the treatment of major depression: A systematic review grading the quality of evidence. Physiother Theory Pract. 2013;29(8):573- 85.
369. Bridle C, Spanjers K, Patel S, Atherton NM, Lamb SE. Effect of exercise on depression severity in older people: systematic review and meta-analysis of randomised controlled trials. Br J Psychiatry. 2012;201(3):180-5.
370. Mammen G, Faulkner G. Physical activity and the prevention of depression: a systematic review of prospective studies. Am J Prev Med. 2013;45(5):649-57.
371. Dunn AL, Trivedi MH, Kampert JB, Clark CG, Chambliss HO. Exercise treatment for depression: efficacy and dose response. Am J Prev Med. 2005;28(1):1-8.
372. Blumenthal JA, Babyak MA, Doraiswamy PM, Watkins L, Hoffman BM, Barbour KA, et al. Exercise and pharmacotherapy in the treatment of major depressive disorder. Psychosom Med. 2007;69(7):587-96.
373. Hoffmann BM, Babyak MA, Craighead WE, Sherwood A, Doraiswamy PM, Coons MJ, et al. Exercise and pharmacotherapy in patients with major depression: one-year follow-up of the SMILE study. Psychosom Med. 2011;73(2):127-33.
374. Mota-Pereira J, Silverio J, Carvalho S, Ribeiro JC, Fonte D, Ramos J. Moderate exercise improves depression parameters in treatment-resistant patients with major depressive disorder. J Psychiatr Res. 2011;45(8):1005-11.
375. Trivedi MH, Greer TL, Church TS, Carmody TJ, Grannemann BD, Galper DI, et al. Exercise as an augmentation treatment for nonremitted major depressive disorder: a randomized, parallel dose comparison. J Clin Psychiatry. 2011;72(5):677-84.
376. Pepping J. St. John’s wort: Hypericum perforatum. Am J Health Syst Pharm. 1999;56(4):329- 30.
377. Thiede HM, Walper A. Inhibition of MAO and COMT by hypericum extracts and hypericin. J Geriatr Psychiatry Neurol 1994;7 Suppl 1:S54-6.
378. Muller WE, Rossol R. Effects of hypericum extract on the expression of serotonin receptors. J Geriatr Psychiatry Neurol. 1994;7 Suppl 1:S63-4.
379. Thiele B, Brink I, Ploch M. Modulation of cytokine expression by hypericum extract. J Geriatr Psychiatry Neurol. 1994;7 Suppl 1:S60-2.
380. Linde K, Berner MM, Kriston L. St John’s wort for major depression. Cochrane Database Syst Rev. 2008(4):CD000448.
381. Rahimi R, Nikfar S, Abdollahi M. Efficacy and tolerability of Hypericum perforatum in major depressive disorder in comparison with selective serotonin reuptake inhibitors: a metaanalysis. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33(1):118-27.
382. Carpenter DJ. St. John’s wort and S-adenosyl methionine as “natural” alternatives to conventional antidepressants in the era of the suicidality boxed warning: what is the evidence for clinically relevant benefit? Altern Med Rev. 2011;16(1):17-39.
383. Sarris J, Fava M, Schweitzer I, Mischoulon D. St John’s wort (Hypericum perforatum) versus sertraline and placebo in major depressive disorder: continuation data from a 26-week RCT. Pharmacopsychiatry. 2012;45(7):275-8.
384. Brattstrom A. Long-term effects of St. John’s wort (Hypericum perforatum) treatment: a 1-year safety study in mild to moderate depression. Phytomedicine. 2009;16(4):277-83.
385. Melzer J, Brignoli R, Keck ME, Saller R. A hypericum extract in the treatment of depressive symptoms in outpatients: an open study. Forsch Komplementmed. 2010;17(1):7-14.
386. Papakostas GI, Crawford CM, Scalia MJ, Fava M. Timing of clinical improvement and symptom resolution in the treatment of major depressive disorder. A replication of findings with the use of a double-blind, placebo-controlled trial of Hypericum perforatum versus fluoxetine. Neuropsychobiology. 2007;56(2-3):132-7.
387. Kasper S, Volz HP, Moller HJ, Dienel A, Kieser M. Continuation and long-term maintenance treatment with Hypericum extract WS 5570 after recovery from an acute episode of moderate depression–a double-blind, randomized, placebo controlled long-term trial. Eur Neuropsychopharmacol. 2008;18(11):803-13.
388. Mannel M, Kuhn U, Schmidt U, Ploch M, Murck H. St. John’s wort extract LI160 for the treatment of depression with atypical features – a double-blind, randomized, and placebocontrolled trial. J Psychiatr Res. 2010;44(12):760-7.
389. Effect of Hypericum perforatum (St John’s wort) in major depressive disorder: a randomized controlled trial. JAMA. 2002;287(14):1807-14.
390. Doran D, Paterson J, Clark C, Srivastava R, Goering PN, Kushniruk AW, et al. A pilot study of an electronic interprofessional evidence-based care planning tool for clients with mental health problems and addictions. Worldviews Evid Based Nurs. 2010;7(3).
391. Atienza G, Bañeres J, Gracia FJ. Guías de práctica clínica en atención primaria. Informe SESPAS 2012. Gac Sanit. 2012;26(Suppl 1):113-7.
392. Trivedi MH, Rush AJ, Crismon ML, Kashner TM, Toprac MG, Carmody TJ, et al. Clinical results for patients with major depressive disorder in the Texas Medication Algorithm Project. Arch Gen Psychiatry. 2004;61(7):669-80.
393. Lobach D, Sanders GD, Bright TJ, Wong A, Dhurjati R, Bristow E, et al. Enabling Health Care Decisionmaking Through Clinical Decision Support and Knowledge Management. Rockville (MD): AHRQ; 2012. Informe Nº.: 12-E001-EF Contrato Nº.: 290-2007-10066-I.
394. Glaser J. Clinical decision support: the power behind the electronic health record. Healthc Financ Manage. 2008;62(7):46-8, 50-1.
395. Latoszek-Berendsen A, Tange H, van den Herik HJ, Hasman A. From Clinical Practice Guidelines to Computer-interpretable Guidelines:A Literature Overview. Metods in Med. 2010;49:550-70.
396. Trivedi MH, Rush AJ, Crismon ML, Kashner TM, Toprac MG, Carmody TJ, et al. Clinical results for patients with major depressive disorder in the Texas Medication Algorithm Project. Trivedi MH, Rush AJ, Crismon ML, . Arch Gen Psychiatry. 2004;61(7):669-80.
397. Kobus AM, Harman JS, Do HD, Garvin RD. Challenges to depression care documentation in an EHR. Fam Med. 2013;45(4):268-71.
398. Sonnenberg FA, Hagerty CG. Computer-interpretable clinical practice guidelines. Where are we and where are we going? Yearb Med Inform. 2006:145 -58.
399. Cannon DS, Allen SN. A comparison of the effects of computer and manual reminders on compliance with a mental health clinical practice guideline. J Am Med Inform Assoc. 2000;7(2):196-203.
400. Rollman BL, Hanusa BH, Gilbert T, Lowe HJ, Kapoor WN, Schulberg HC. The electronic medical record. A randomized trial of its impact on primary care physicians’ initial management of major depression [corrected]. Arch Intern Med. 2001;161(2):189-97.
401. Kurian BT, Trivedi MH, Grannemann BD, Claassen CA, Daly EJ, Sunderajan P. A computerized decision support system for depression in primary care. Prim Care Companion J Clin Psychiatry. 2009;11(4):140-6.
402. Williams LS, Ofner S, Yu Z, Beyth RJ, Plue L, Damush T. Pre-post evaluation of automated reminders may improve detection and management of post-stroke depression. J Gen Intern Med. 2011;26(8):852-7.
403. Gill JM, Chen YX, Grimes A, Klinkman MS. Using electronic health record-based tools to screen for bipolar disorder in primary care patients with depression. J Am Board Fam Med. 2012;25(3):283-90.
404. López-Pedraza Gómez MJ, Hernández Meléndez MT, Blasco Amaro JA. Guía Clínica Electrónica: Cáncer de mama. Madrid: Ministerio de Economía y Competitividad; 2011. Informe No.: UETS 2010/07.
405. Tierney WM, Overhage JM, Takesue BY, Harris LE, Murray MD, Vargo DL, et al. Computerizing guidelines to improve care and patient outcomes: the example of heart failure. J Am Med Inform Assoc. 1995;2(5):316-22.
406. Trivedi MH, Daly EJ, Kern JK, Grannemann BD, Sunderajan P, Claassen CA. Barriers to implementation of a computerized decision support system for depression: an observational report on lessons learned in “real world” clinical settings. BMC Med Inform Decis Mak. 2009;21(9):6.
407. Triñanes Y, Senra-Rivera C, Seoane-Pesqueira G, González-García A, Alvarez-Ariza M, de- Las-Heras-Liñero E, et al. Satisfacción y utilidad percibidas por pacientes y familiares acerca de la información sobre prevención de suicidio. Rev Calid Asist. 2014;29(1):36-42.
408. Palao DJ, Cavero M, Comín E, Bonet S, Gerrero AJ, Moreno MD, et al. Estudio controlado de la implementación de una Guia Computarizada de la Depresión en Atención Primaria. PI12/01585.