En
Bibliografía

1 Grupo de trabajo sobre GPC. Elaboración de guías de práctica clínica en el Sistema Nacional de Salud. Manual metodológico. Madrid: Plan Nacional para el SNS del MSC. Instituto Aragonés de Ciencias de la Salud - I+CS; 2007.

2 Vázquez JA. Situación actual de la epidemiología de la enfermedad meningocócica. Enferm Infecc Microbiol Clin. 2006;24(Supl 1):14-8.

3 Comentario epidemiológico de las enfermedades de declaración obligatoria y sistema de información microbiológica. España. Año 2010. Boletín Epidemiológico Semanal. 2011;19(8):100-16.

4 European Centre for Disease Prevention and Control. Public health management of sporadic cases of invasive meningococcal disease and their contacts. Stockholm: ECDC; 2010.

5 National Collaborating Centre for Women’s and Children’s Health, Commissioned by the National Institute for Health and Clinical Excellence. Bacterial meningitis and meningococcal septicaemia. Management of bacterial meningitis and meningococcal septicaemia in children and young people younger than 16 years in primary and secondary care. London: Royal College of Obstetricians and Gynaecologists; 2010.

6 Scottish Intercollegiate Guidelines Network. Management of invasive meningococcal disease in children and young people: a national clinical guideline. Edinburgh: SIGN; 2008.

7 Chaudhuri A, Martinez-Martin P, Kennedy PG, Andrew SR, Portegies P, Bojar M, et al. EFNS guideline on the management of community-acquired bacterial meningitis: report of an EFNS Task Force on acute bacterial meningitis in older children and adults. Eur J Neurol. 2008;15(7):649-59.

8 Tunkel AR, Hartman BJ, Kaplan SL, Kaufman BA, Roos KL, Scheld WM, et al. Practice guidelines for the management of bacterial meningitis. Clin Infect Dis. 2004;39(9):1267-84.

9 Etxeberria A, Rotaeche R, Lekue I, Callén B, Merino M, Villar M, et al. Descripción la metodología de elaboración-adaptación-actualización empleada en la guía de práctica clínica sobre asma de la CAPV. Vitoria-Gasteiz: Departamento de Sanidad. Gobierno Vasco; 2005.

10 Stephens DS, Greenwood B, Brandtzaeg P. Epidemic meningitis, meningococcaemia, and Neisseria meningitidis. Lancet. 2007;369(9580):2196-210.

11 Zhu H, Wang Q, Wen L, Xu J, Shao Z, Chen M, et al. Development of a multiplex PCR assay for detection and genogrouping of Neisseria meningitidis. J Clin Microbiol. 2012;50(1):46-51.

12 Harrison LH, Trotter CL, Ramsay ME. Global epidemiology of meningococcal disease. Vaccine. 2009;27(Suppl 2):B51-B63.

13 Halperin SA, Bettinger JA, Greenwood B, Harrison LH, Jelfs J, Ladhani SN, et al. The changing and dynamic epidemiology of meningococcal disease. Vaccine. 2012;30 Suppl 2:B26-B36.

14 Choudhuri D, Huda T, Theodoratou E, Nair H, Zgaga L, Falconer R, et al. An evaluation of emerging vaccines for childhood meningococcal disease. BMC Public Health. 2011;11(Suppl 3):S29-S42.

15 Ibarz-Pavon AB, Lemos AP, Gorla MC, Regueira M, Gabastou JM. Laboratory-based surveillance of Neisseria meningitidis isolates from disease cases in Latin American and Caribbean countries, SIREVA II 2006-2010. PLoS One. 2012;7(8):e44102.

16 European Centre for Disease Prevention and Control. Surveillance of invasive bacterial diseases in Europe 2008/2009. Stockholm: ECDC ed. 2011.

17 Mateo S, Cano R, Garcia C. Changing epidemiology of meningococcal disease in Spain, 1989-1997. Euro Surveill. 1997;2(10):71-4.

18 Cano R, Garrido M. Enfermedad meningocócica en España. Análisis de la temporada 2006-2007. Boletín Epidemiológico Semanal. 2008;16(7):73-84.

19 Centro Nacional de Epidemiología. Comentario epidemiológico de las Enfermedades de Declaración Obligatoria y Sistema de Información Microbiológica. España. Año 2011. Boletín Epidemiológico Semanal. 2012;20(14):124-39.

20 Rosenstein NE, Perkins BA, Stephens DS, Popovic T, Hughes JM. Meningococcal disease. N Engl J Med. 2001;344(18):1378-88.

21 de Souza AL, Seguro AC. Two centuries of meningococcal infection: from Vieusseux to the cellular and molecular basis of disease. J Med Microbiol. 2008;57(Pt 11):1313-21.

22 Haj-Hassan TA, Thompson MJ, Mayon-White RT, Ninis N, Harnden A, Smith LF, et al. Which early ‘red flag’ symptoms identify children with meningococcal disease in primary care? Br J Gen Pract. 2011;61(584):e97-104.

23 Karanika M, Vasilopoulou VA, Katsioulis AT, Papastergiou P, Theodoridou MN, Hadjichristodoulou CS. Diagnostic clinical and laboratory findings in response to predetermining bacterial pathogen: data from the Meningitis Registry. PLoS One. 2009;4(7):e6426.

24 Barroso DE, Carvalho DM, Casagrande ST, Rebelo MC, Soares V, Zahner V, et al. Microbiological epidemiological history of meningococcal disease in Rio de Janeiro, Brazil. Braz J Infect Dis. 2010;14(3):242-51.

25 Health Protection Agency Meningococcus Forum. Guidance for public health management of meningococcal disease in the UK. London ed. 2006.

26 Thompson M, Van den BA, Verbakel J, Lakhanpaul M, Haj-Hassan T, Stevens R, et al. Systematic review and validation of prediction rules for identifying children with serious infections in emergency departments and urgent-access primary care. Health Technol Assess. 2012;16(15):1-100.

27 Perez-Ruiz M, Vicente D, Navarro-Mari JM. Infecciones agudas del sistema nervioso central (meningitis y encefalitis) virales y bacterianas de origen autóctono. Enferm Infecc Microbiol Clin. 2008;26(Suppl 9):8-14.

28 Esparcia O, Montemayor M, Ginovart G, Pomar V, Soriano G, Pericas R, et al. Diagnostic accuracy of a 16S ribosomal DNA gene-based molecular technique (RT-PCR, microarray, and sequencing) for bacterial meningitis, early-onset neonatal sepsis, and spontaneous bacterial peritonitis. Diagn Microbiol Infect Dis. 2011;69(2):153-60.

29 McKenna JP, Fairley DJ, Shields MD, Cosby SL, Wyatt DE, McCaughey C, et al. Development and clinical validation of a loop-mediated isothermal amplification method for the rapid detection of Neisseria meningitidis. Diagn Microbiol Infect Dis. 2011;69(2):137-44.

30 Muñoz-Almagro C, Palomeque A, Roca J, Gené A, Palacín E, Latorre C. Aumento de la rentabilidad diagnóstica en la enfermedad meningocócica mediante la técnica de reacción en cadena de la polimerasa. Med Clin (Barc). 2003;120(19):721-4.

31 Nagamine K, Hase T, Notomi T. Accelerated reaction by loop-mediated isothermal amplification using loop primers. Mol Cell Probes. 2002;16(3):223-9.

32 Notomi T, Okayama H, Masubuchi H, Yonekawa T, Watanabe K, Amino N, et al. Loop-mediated isothermal amplification of DNA. Nucleic Acids Res. 2000;28(12):E63.

33 Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med. 2008;34(1):17-60.

34 Daza Pérez RM. Resistencia bacteriana a antimicrobianos: su importancia en la toma de decisiones en la práctica diaria. Inf Ter Sist Nac Salud. 1998;22(3):57-67.

35 Saez Nieto JA, Vazquez JA. Moderate resistance to penicillin in Neisseria meningitidis. Microbiologia. 1997;13(3):337-42.

36 Sudarsanam T, Rupali P, Tharyan P, Abraham OC, Thomas K. Pre-admission antibiotics for suspected cases of meningococcal disease. Cochrane Database Syst Rev. 2008;(1):CD005437.

37 Gunnell DJ, Pearson N, Ley B, Hill A. Epidemiology of meningococcal disease and a community outbreak in Somerset. Commun Dis Rep CDR Rev. 1994;4(9):R101-R104.

38 Hahne SJ, Charlett A, Purcell B, Samuelsson S, Camaroni I, Ehrhard I, et al. Effectiveness of antibiotics given before admission in reducing mortality from meningococcal disease: systematic review. BMJ. 2006;332(7553):1299-303.

39 Plan de Calidad para el Sistema Nacional de Salud. Ministerio de Sanidad, Servicios Sociales e Igualdad. Última actualización: 2010. Fecha de consulta: 2012 Sep 10. Disponible en: http://www.msssi.gob.es/organizacion/sns/planCalidadSNS/home.htm

40 de la Torre MV (coordinadora), et al. Sepsis grave. Proceso asistencial integrado. Sevilla: Junta de Andalucía.Consejería de Salud; 2010.

41 Val Pérez JV, Díaz López Y. Proyecto PIMIS: Unidad Funcional multidisciplinar de Sepsis de la Fundación Hospital Son Llàtzer. Gest y Eval Cost Sanit. 2011;12(4):75-86.

42 Menendez R, Torres A, Zalacain R, Aspa J, Martin-Villasclaras JJ, Borderias L, et al. Guidelines for the treatment of community-acquired pneumonia: predictors of adherence and outcome. Am J Respir Crit Care Med. 2005;172(6):757-62.

43 Guimont C, Hullick C, Durrheim D, Ryan N, Ferguson J, Massey P. Invasive meningococcal disease--improving management through structured review of cases in the Hunter New England area, Australia. J Public Health (Oxf). 2010;32(1):38-43.

44 Martin-Aspas A, Suarez-Lozano I, Fajardo Pico JM, Ramirez E, Menchero A, de la Iglesia A. Evaluación de la práctica clínica en los pacientes diagnosticados de meningitis infecciosa. Enferm Infecc Microbiol Clin. 2007;25(4):242-6.

45 Callegaro S, Titomanlio L, Donega S, Tagliaferro T, Andreola B, Gibertini GG, et al. Implementation of a febrile seizure guideline in two pediatric emergency departments. Pediatr Neurol. 2009;40(2):78-83.

46 Molyneux E, Nizami SQ, Saha S, Huu KT, Azam M, Bhutta ZA, et al. 5 versus 10 days of treatment with ceftriaxone for bacterial meningitis in children: a double-blind randomised equivalence study. Lancet. 2011;377(9780):1837-45.

47 Pelkonen T, Roine I, Cruzeiro ML, Pitkaranta A, Kataja M, Peltola H. Slow initial beta-lactam infusion and oral paracetamol to treat childhood bacterial meningitis: a randomised, controlled trial. Lancet Infect Dis. 2011;11(8):613-21.

48 De Gaudio M, Chiappini E, Galli L, De MM. Therapeutic management of bacterial meningitis in children: a systematic review and comparison of published guidelines from a European perspective. J Chemother. 2010;22(4):226-37.

49 Jarvis CW, Saxena KM. Does prior antibiotic treatment hamper the diagnosis of acute bacterial meningitis? An analysis of a series of 135 childhood cases. Clin Pediatr (Phila). 1972;11(4):201-4.

50 Laman M, Manning L, Hwaiwhange I, Vince J, Aipit S, Mare T, et al. Lumbar puncture in children from an area of malaria endemicity who present with a febrile seizure. Clin Infect Dis. 2010;51(5):534-40.

51 Mintegi S, Benito J, Astobiza E, Capape S, Gomez B, Eguireun A. Well appearing young infants with fever without known source in the emergency department: are lumbar punctures always necessary? Eur J Emerg Med. 2010;17(3):167-9.

52 Tinsa F, El GA, Ncibi N, Bouguerra C, Ben AW, Zouari B, et al. L’utilité de la ponction lombaire en cas de convulsion fébrile chez le nourrisson âgé de moins d’un an. Tunis Med. 2010;88(3):178-83.

53 Joshi BR, Rayamajhi A, Mahaseth C. Children with first episode of fever with seizure: is lumbar puncture necessary? JNMA J Nepal Med Assoc. 2008;47(171):109-12.

54 Galiza EP, Heath PT. Improving the outcome of neonatal meningitis. Curr Opin Infect Dis. 2009;22(3):229-34.

55 Donoso FA, Fuentes FC, Arriagada SD. Enfermedad meningocócica neonatal. An Pediatr (Barc ). 2011;75(3):213-5.

56 Shacham S, Kozer E, Bahat H, Mordish Y, Goldman M. Bulging fontanelle in febrile infants: is lumbar puncture mandatory? Arch Dis Child. 2009;94(9):690-2.

57 Alonso Salas M, de Carlos Vicente J, Gil Antón J, Pinto Fuentes I, Quintilla Martínez J, Sánchez Díaz J. Sociedad Española de Urgencias de Pediatría. Documento de consenso SECIP-SEUP sobre manejo de sepsis grave y Shock séptico en pediatría. Última actualización: 2008January 1. Fecha de consulta: 2012 Sep 3.

58 Garcia GE, Milano MG, Lopez Siguero JP, Valls ME, Calvo MC. Función suprarrenal en niños con sepsis y shock séptico. An Esp Pediatr. 2001;54(5):439-43.

59 Brouwer MC, McIntyre P, de GJ, Prasad K, van de BD. Corticosteroids for acute bacterial meningitis. Cochrane Database Syst Rev. 2010;(9):CD004405.

60 Tolaj I, Dreshaj S, Qehaja E, Tolaj J, Doda-Ejupi T, Mehmeti M. Dexamethasone as adjuvant therapy in the treatment of invasive meningococcal diseases. Med Arh. 2010;64(4):228-30.

61 Maconochie I, Baumer H, Stewart ME. Fluid therapy for acute bacterial meningitis. Cochrane Database Syst Rev. 2011;(2):CD004786.

62 Lopez-Herce CJ, Carrillo AA, Calvo MC. Estabilización posresucitación y transporte. An Pediatr (Barc ). 2006;65(6):578-85.

63 Bouchut J-C, Van LE, Chritin V, Gueugniaud P-Y. Physical stressors during neonatal transport: Helicopter compared with ground ambulance. Air Medical Journal. 2011;30(3):134-9.

64 Castellanos OA, Gandarillas Gonzalez MA, Teja Barbero JL, Ortiz MF, Obeso GT, Prieto VF, et al. Definiciones de sepsis en la infección meningocócica infantil grave: una revisión de 80 casos. An Esp Pediatr. 1996;44(3):219-24.

65 Rodriguez-Nunez A, Lopez-Herce J, Gil-Anton J, Hernandez A, Rey C. Rescue treatment with terlipressin in children with refractory septic shock: a clinical study. Crit Care. 2006;10(1):R20.

66 Khalil T, Leteurtre S, Fonteyne C, Sadik A, Biarent D, Leclerc F. Safety and usefulness of invasive arterial blood pressure monitoring in purpura fulminans resuscitation. Med Sci Monit. 2007;13(4):CR182-CR186.

67 Odetola FO, Tilford JM, Davis MM. Variation in the use of intracranial-pressure monitoring and mortality in critically ill children with meningitis in the United States. Pediatrics. 2006;117(6):1893-900.

68 Best C, Walsh J, Sinclair J, Beattie J. Early haemo-diafiltration in meningococcal septicaemia. Lancet. 1996;347(8995):202.

69 Camporota L, Wyncoll D. Practical aspects of treatment with drotrecogin alfa (activated). Crit Care. 2007;11 Suppl 5:S7.

70 Veldman A, Fischer D, Wong FY, Kreuz W, Sasse M, Eberspacher B, et al. Human protein C concentrate in the treatment of purpura fulminans: a retrospective analysis of safety and outcome in 94 pediatric patients. Crit Care. 2010;14(4):R156.

71 Alejandria MM, Lansang-Mary AD, Dans LF, Mantaring-III JB. Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock. Cochrane Database of Systematic Reviews. 2002;(1):CD001090.

72 European Medicines Agency HMDaE. Xigris (drotrecogin alfa (activated)): Withdrawal of the marketing authorisation in the European Union. Londres: EMA; 2012. Report No.: EMA/128419/2012.

73 Kuppermann N, Inkelis SH, Saladino R. The role of heparin in the prevention of extremity and digit necrosis in meningococcal purpura fulminans. Pediatr Infect Dis J. 1994;13(10):867-73.

74 Corrigan JJ, Jr., Jordan CM. Heparin therapy in septicemia with disseminated intravascular coagulation. N Engl J Med. 1970;283(15):778-82.

75 Manios SG, Kanakoudi F, Maniati E. Fulminant meningococcemia. Heparin therapy and survival rate. Scand J Infect Dis. 1971;3(2):127-33.

76 Haneberg B, Gutteberg TJ, Moe PJ, Osterud B, Bjorvatn B, Lehmann EH. Heparin for infants and children with meningococcal septicemia. Results of a randomized therapeutic trial. NIPH Ann. 1983;6(1):43-7.

77 Numanoglu A, Bickler SW, Rode H, Bosenberg AT. Meningococcal septicaemia complications involving skin and underlying deeper tissues--management considerations and outcome. S Afr J Surg. 2007;45(4):142-6.

78 Bache CE, Torode IP. Orthopaedic sequelae of meningococcal septicemia. J Pediatr Orthop. 2006;26(1):135-9.

79 Andres AM, Lopez Gutierrez JC, Rivas S, De l, V, Ros Z, Diaz M, et al. Tratamiento quirúrgico de las complicaciones cutáneas y musculoesqueléticas de los pacientes con sepsis. Cir Pediatr. 2006;19(2):66-71.

80 Boeckx WD, Nanhekhan L, Vos GD, Leroy P, Van den KE. Minimizing limb amputations in meningococcal sepsis by early microsurgical arteriolysis. J Pediatr Surg. 2009;44(8):1625-30.

81 Casado-Flores J, Blanco-Quiros A, Nieto M, Asensio J, Fernandez C. Prognostic utility of the semi-quantitative procalcitonin test, neutrophil count and C-reactive protein in meningococcal infection in children. Eur J Pediatr. 2006;165(1):26-9.

82 da Silva PSL, Iglesias SBO, Nakakura CH, de A, V, de Carvalho WB. The product of platelet and neutrophil counts (PN product) at presentation as a predictor of outcome in children with meningococcal disease. Annals of Tropical Paediatrics. 2007;27(1):25-30.

83 Aguilar-Garcia J, Olalla-Sierra J, Perea-Milla E, Rivas-Ruiz F, Martos F, Sanchez-Cantalejo E, et al. Análisis de las características epidemiológicas y de los factores pronósticos en la enfermedad meningocócica invasiva probable o confirmada en una cohorte de adolescentes y adultos durante un brote epidémico. Rev Clin Esp. 2009;209(5):221-6.

84 de Jonge RC, van Furth AM, Wassenaar M, Gemke RJ, Terwee CB. Predicting sequelae and death after bacterial meningitis in childhood: a systematic review of prognostic studies. BMC Infect Dis. 2010;10:232.

85 Antoniuk SA, Hamdar F, Ducci RD, Kira AT, Cat MN, da Cruz CR. Childhood acute bacterial meningitis: risk factors for acute neurological complications and neurological sequelae. J Pediatr (Rio J ). 2011;87(6):535-40.

86 Venegas S. C, Retamales M, Hettich V, Retamales M, Bustos L, Boehme C. Relación entre parámetros de laboratorio y pronóstico en meningitis bacteriana aguda en el Hospital Hernán Henríquez de Temuco. Rev Chil Cienc Méd Biol. 2003;13(2):35-9.

87 Donoso F, León B, Rojas A, Ramírez A, Oberpaur W. Valor de la leucopenia durante la primera hora como marcador pronóstico en la enfermedad meningococcica. Rev chil pediatr. 2004;75(5):441-7.

88 Blanco Quirós A, Casado Flores J, Nieto Moro M, Garrote Adrados JA, Arranz Sanz E, Asensio Antón J. Sepsis meningocócica en pediatría. Parámetros asociados a mala evolución. An Pediatr (Barc). 2004;61:305-13.

89 Castellanos-Ortega A, gado-Rodriguez M, Llorca J, Sanchez BP, Mencia BS, Soult RA, et al. A new prognostic scoring system for meningococcal septic shock in children. Comparison with three other scoring systems. Intensive Care Med. 2002;28(3):341-51.

90 Leteurtre S, Duhamel A, Grandbastien B, Proulx F, Cotting J, Gottesman R, et al. Daily estimation of the severity of multiple organ dysfunction syndrome in critically ill children. CMAJ. 2010;182(11):1181-7.

91 Celaj E, Sallabanda S, Kola E, Lluka R, Zavalani F, Klironomi I, et al. Importance of scoring systems in prognostic meningococcemia. Intensive Care Medicine. 2009;35 Suppl. 1:S233.

92 Reilly PL, Simpson DA, Sprod R, Thomas L. Assessing the conscious level in infants and young children: a paediatric version of the Glasgow Coma Scale. Childs Nerv Syst. 1988;4(1):30-3.

93 Simpson D, Reilly P. Pediatric coma scale. Lancet. 1982;2(8295):450.

94 Hastings L, Stuart J, Andrews N, Begg N. A retrospective survey of clusters of meningococcal disease in England and Wales, 1993 to 1995: estimated risks of further cases in household and educational settings. Commun Dis Rep CDR Rev. 1997;7(13):R195-R200.

95 Hoek MR, Christensen H, Hellenbrand W, Stefanoff P, Howitz M, Stuart JM. Effectiveness of vaccinating household contacts in addition to chemoprophylaxis after a case of meningococcal disease: A systematic review. Epidemiology and Infection. 2008;136(11):1441-7.

96 Hellenbrand W, Hanquet G, Heuberger S, Nielsen S, Stefanoff P, Stuart JM. What is the evidence for giving chemoprophylaxis to children or students attending the same preschool, school or college as a case of meningococcal disease? Epidemiol Infect. 2011;1-11.

97 Red Nacional de Vigilancia Epidemiológica. Sistema de Vigilancia Epidemiológica de Andalucía (SVEA). Protocolo de Vigilancia y Alerta de enfermedad Meningocócica. Sevilla: SVEA. Última actualización: 2011 October 1. Fecha de consulta: 2012 Dec 14. Disponible en: http://www.juntadeandalucia.es/salud/export/sites/csalud/galerias/documentos/p_4_p_1_vigilancia_de_la_salud/p_MENINGOCOCICA_2011.pdf

98 Fraser A, Gafter-Gvili A, Paul M, Leibovici L. Antibiotics for preventing meningococcal infections. Cochrane Database Syst Rev. 2006;(4):CD004785.

99 Zalmanovici Trestioreanu A, Fraser A, Gafter-Gvili A, Paul M, Leibovici L. Antibiotics for preventing meningococcal infections. Cochrane Database Syst Rev. 2011;(8):CD004785.

100 Schwartz B, Al-Tobaiqi A, Al-Ruwais A, Fontaine RE, A’ashi J, Hightower AW, et al. Comparative efficacy of ceftriaxone and rifampicin in eradicating pharyngeal carriage of group A Neisseria meningitidis. Lancet. 1988;1(8597):1239-42.

101 Simmons G, Jones N, Calder L. Equivalence of ceftriaxone and rifampicin in eliminating nasopharyngeal carriage of serogroup B Neisseria meningitidis. J Antimicrob Chemother. 2000;45(6):909-11.

102 Cuevas LE, Kazembe P, Mughogho GK, Tillotson GS, Hart CA. Eradication of nasopharyngeal carriage of Neisseria meningitidis in children and adults in rural Africa: a comparison of ciprofloxacin and rifampicin. J Infect Dis. 1995;171(3):728-31.

103 Bilukha OO, Rosenstein N. Prevention and control of meningococcal disease. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2005;54(RR-7):1-21.

104 Health Protection Agency Meningococcus and Haemophilus Forum. Guidance for public health management of meningococcal disease in the UK. London ed. 2011.

105 Siegel JD, Rhinehart E, Jackson M, Chiarello L. 2007 Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Health Care Settings. Am J Infect Control. 2007;35(10 Suppl 2):S65-164.

106 Buysse CM, Raat H, Hazelzet JA, Hulst JM, Cransberg K, Hop WC, et al. Long-term health status in childhood survivors of meningococcal septic shock. Arch Pediatr Adolesc Med. 2008;162(11):1036-41.

107 Borg J, Christie D, Coen PG, Booy R, Viner RM. Outcomes of meningococcal disease in adolescence: prospective, matched-cohort study. Pediatrics. 2009;123(3):e502-e509.

108 Edmond K, Clark A, Korczak VS, Sanderson C, Griffiths UK, Rudan I. Global and regional risk of disabling sequelae from bacterial meningitis: a systematic review and meta-analysis. Lancet Infect Dis. 2010;10(5):317-28.

109 Gottfredsson M, Reynisson IK, Ingvarsson RF, Kristjansdottir H, Nardini MV, Sigurdsson JF, et al. Comparative Long-term Adverse Effects Elicited by Invasive Group B and C Meningococcal Infections. Clin Infect Dis. 2011;53(9):e117-e124.

110 Buysse CM, Oranje AP, Zuidema E, Hazelzet JA, Hop WC, Diepstraten AF, et al. Long-term skin scarring and orthopaedic sequelae in survivors of meningococcal septic shock. Arch Dis Child. 2009;94(5):381-6.

111 Buysse CM, Vermunt LC, Raat H, Hazelzet JA, Hop WC, Utens EM, et al. Surviving meningococcal septic shock in childhood: long-term overall outcome and the effect on health-related quality of life. Crit Care. 2010;14(3):R124.

112 Vermunt LC, Buysse CM, Aarsen FK, Catsman-Berrevoets CE, Duivenvoorden HJ, Joosten KF, et al. Long-term cognitive functioning in children and adolescents who survived septic shock caused by Neisseria meningitidis. Br J Clin Psychol. 2009;48(Pt 2):195-208.

113 Vermunt LC, Buysse CM, Joosten KF, Hazelzet JA, Verhulst FC, Utens EM. Behavioural, emotional, and post-traumatic stress problems in children and adolescents, long term after septic shock caused by Neisseria meningitidis. Br J Clin Psychol. 2008;47(Pt 3):251-63.

114 Garralda ME, Gledhill J, Nadel S, Neasham D, O’Connor M, Shears D. Longer-term psychiatric adjustment of children and parents after meningococcal disease. Pediatr Crit Care Med. 2009;10(6):675-80.

115 Kai J. What worries parents when their preschool children are acutely ill, and why: a qualitative study. BMJ. 1996;313(7063):983-6.

116 Ramritu PL, Croft G. Needs of parents of the child hospitalised with acquired brain damage. Int J Nurs Stud. 1999;36(3):209-16.

117 Doxa, Fundación Irene Megías contra la Meningitis. Investigación sociológica: conciencia, conocimientos y actitudes respecto a la meningitis en España [Informe en Internet]. [Madrid]: Ministerio de Sanidad y Consumo; 2007 [consultado 19 de diciembre de 2011]. 91 p. Disponible en: http://www.contralameningitis.org/images/stories/documentos/Informe%20Estudio%20sociologico%20sobre%20Meningitis.pdf.

118 Clark L, Glennie L, Hickman M, Audrey S, Trotter C. Meeting the health, social, and educational needs of children who have survived meningitis and septicaemia: the parents perspective [en línea]. Póster presentado en: Conference Meningitis and septicaemia in children and adults; 2011, [Consultado 22 de diciembre de 2011] Londres. Disponible en: http://www.meningitis.org/assets/x/53931.

119 Buysse CM, Raat H, Hazelzet JA, Hop WC, Maliepaard M, Joosten KF. Surviving meningococcal septic shock: health consequences and quality of life in children and their parents up to 2 years after pediatric intensive care unit discharge. Crit Care Med. 2008;36(2):596-602.

120 Vermunt LC, Buysse CM, Joosten KF, Hazelzet JA, Verhulst FC, Utens EM. Recovery in parents of children and adolescents who survived septic shock caused by Neisseria meningitidis: a cross-sectional study. Intensive Crit Care Nurs. 2010;26(3):128-37.

121 Buysse CM, Raat H, Hazelzet JA, Vermunt LC, Utens EM, Hop WC, et al. Long-term healthrelated quality of life in survivors of meningococcal septic shock in childhood and their parents. Qual Life Res. 2007;16(10):1567-76.

122 Ware JE, Jr., Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992;30(6):473-83.

123 Aurel M, Dubos F, Motte B, Pruvost I, Leclerc F, Martinot A. Recognising haemorrhagic rash in children with fever: a survey of parents’ knowledge. Arch Dis Child. 2011;96(7):697-8.

124 Meningococcal disease. Meningitis Research Foundation. Última actualización: 2009. Disponible en: www.meningitis.org/assets/x/50114

125 Management of meningococcal disease in children and young people. Meningitis Research Foundation. Última actualización: 2009. Disponible en: www.meningitis.org/assets/x/50150

126 Management of bacterial meningitis in children and young people. Meningitis Research Foundation. Última actualización: 2009. Disponible en: www.meningitis.org/assets/x/53067

127 Gardner P. Clinical practice. Prevention of meningococcal disease. N Engl J Med. 2006;355(14):1466-73.

128 Meningitis y septicemia. Meningitis Research Foundation. Última actualización: 2007. Fecha de consulta: 2012 Sep 11. Disponible en: http://www.meningitis.org/assets/x/50250

129 La meningitis. Children’s Hospitals and Clinics of Minnesota Patien/family education. Última actualización: 2006 December. Fecha de consulta: 2012 Sep 4. Disponible en: http://www.childrensmn.org/patientfamily/family-services-a-resources/education-materials-a-z

130 Meningitis. MedlinePlus Información de salud para usted. Última actualización: 2011 June. Fecha de consulta: 2012 Sep 11. Disponible en: http://www.nlm.nih.gov/medlineplus/spanish/meningitis.html

131 Wallace M, Harcourt D, Rumsey N. Adjustment to appearance changes resulting from meningococcal septicaemia during adolescence: a qualitative study. Dev Neurorehabil. 2007;10(2):125-32.

132 Meningitis and childhood deafness. Information for families. National Deaf Children’s Society and Meningitis Trust. Última actualización: 2012 January. Fecha de consulta: 2012 Nov 12. Disponible en: http://www.meningitis-trust.org/meningitis-info/after-meningitis/hearing-andsight-loss/

133 Booy R, Iskander M, Viner R. Prevention of meningococcal disease. N Engl J Med.2007;356(5):524-5.

134 Bereavement following meningitis. How we can support you. Meningitis Trust. Última actualización: 2012 February. Fecha de consulta: 2012 Sep 4. Disponible en: http://www.meningitistrust.org/meningitis-info/after-meningitis/bereavement/