En
Bibliografía

1. American College of Obstetricians and Gynecologist and American Academy of Pediatrics. Neonatal Encephalopathy and Cerebral Palsy: Executive summary. Obstet Gynecol. 2004; 103(4): 780-1.

2. Freeman JM., Nelson KB. Intrapartum asphyxia and cerebral palsy. Pediatrics. 1988; 82(2): 240-9.

3. Nelson KB., Leviton A. How much of neonatal encephalopathy is due to birth asphyxia? Am J Dis Child. 1991; 145(11): 1325-31.

4. MacLennan A. A template for defining a causal relation between acute intrapartum events and cerebral palsy: international consensus statement. BMJ. 1999; 319(7216): 1054-9.

5. Paneth N., Stark RI. Cerebral palsy and mental retardation in relation to indicators of perinatal asphyxia. An epidemiologist overwiew. Am J Obstet Gynecol. 1983; 147(8): 960-6.

6. NHS Litigation Authority. Factsheet 2: financial information. London: National Health Service Litigation Authority; July 2013 [acceso Julio 2013]. Disponible en: http://www.nhsla.com/currentactivity/Documents/NHS%20LA%20Factsheet%202%20-%20financial% 20information%202012-13.pdf

7. Hull J., Dodd KL. Falling incidence of hypoxic-ischaemic encephalopathy in term infants. Br J Obstet Gynaecol. 1992; 99(5): 386-91.

8. Smith J., Wells L., Dodd K. The continuing fall in incidence of hypoxic-ischaemic encephalopathy in term infants. BJOG. 2000; 107(4): 461-6.

9. Becher JC., Stenson BJ., Lyon AJ. Is intrapartum asphyxia preventable? BJOG. 2007; 114(11): 1442-4.

10. Thornberg E., Thiringer K., Odeback A., Milsom I. Birth asphyxia: incidence, clinical course and outcome in a Swedish population. Acta Paediatr. 1995; 84(8): 927-32.

11. Levene MI., Kornberg J., Williams THC. The incidence and severity of postasphyxia encephalopathy in full-term infants. Early Hum Dev. 1985; 11(1): 21-6.

12. González de Dios J., Moya M., Vioque J. Factores de riesgo predictivos de secuelas neurológicas en recién nacidos a término con asfixia perinatal. Rev Neurol. 2001; 32(3): 201-6.

13. Esqué MT., Baraibar R., Figueras J., Maurí E., Moretones MG., Padula C., et al. Estudio multicéntrico sobre asfixia neonatal. An Esp Pediatr. 1985; 23(8): 542-50.

14. García-Alix A., Martínez Biarge M. Incidencia y Prevalencia de la encefalopatía hipóxico-isquémica (EHI) perinatal: necesidad de regionalizar y centralizar los programas de hipotermia moderada sostenida en el recién nacido con EHI. An Pediatr (Barc). 2009; 71: 319-26.

15. Tenorio V., Alarcón A., García-Alix A., Arca G., Camprubí M., Agut T., et al. Hipotermia cerebral moderada en la encefalopatía hipóxico-isquémica. Experiencia en el primer año de su puesta en marcha. An Pediatr (Barc). 2012; 77(2): 88-97.

16. Sarnat HB., Sarnat MS. Neonatal encephalopathy following fetal distress: a clinical and electroencephalographic study. Arch Neurol. 1976; 33(10): 698-705.

17. Amiel-Tison C., Ellison P. Birth asphyxia in the full-term newborn: Early assessment and outcome. Dev Med Child Neurol. 1986; 28(5): 671-82.

18. García-Alix A., Cabañas F., Pellicer A., Hernanz A., Stiris TA., Quero J. Neuronspecific enolase and myelin basic protein: relationship of cerebrospinal fluid concentrations to the neurologic condition of asphyxiated full-term infants. Pediatrics. 1994; 93(2): 234-40.

19. Miller SP., Latal B., Clark H., Barnwell A., Glidden D., Barkovich AJ., et al. Clinical signs predict 30-month neurodevelopmental outcome after neonatal encephalopathy. Am J Obstet Gynecol. 2004; 190(1): 93-9.

20. Thompson CM., Puterman AS., Linley LL., Hann FM., van der Elst CW, Molteno CD., et al. The value of a scoring system for hypoxic ischaemic encephalopathy in predicting neurodevelopmental outcome. Acta Paediatr. 1997; 86(7): 757-61.

21. González de Dios J. Definición de asfixia peritanal en la bibliografía médica: necesidad de un consenso. Rev Neurol. 2002; 35(7): 628-34.

22. Gadian D,G., Aicardi J., Watkins KE., Porter DA., Mishkin M., Vargha-Khadem F. Developmental amnesia associated with early hypoxic-ischemic injury. Brain. 2000; 123(3): 499-507.

23. Van Handel M., Sonneville L., de Vries LS., Jongmans MJ., Swaab H. Specific memory impairment following neonatal encephalopathy in term-born children. Dev Neuropsychology. 2012; 37(1): 30-50.

24. Hellström-Westas L., Rosén I. Continuous brain-function monitoring: state of the art in clinical practice. Semin Fetal Neonatal Med. 2006; 11(6): 503-11.

25. Spitzmiller RE., Phillips T., Meinzen-Derr J., Hoath SB. Amplitude-integrated EEG is useful in predicting neurodevelopmental outcome in full-term infants with hypoxicischemic encephalopathy: a meta-analysis. J Child Neurol. 2007; 22(9): 1069-78.

26. Levene MI., Fenton AC., Evans DH., Archer LN., Shortland DB., Gibson NA. Severe birth asphyxia and abnormal cerebral blood-flow velocity. Dev Med Child Neurol. 1989; 31(4): 427-34.

27. Eken P., Toet MC., Groenendaal F., de Vries LS. Predictive value of early neuroimaging, pulsed Doppler and neurophysiology in full term infants with hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed. 1995; 73(2): F75-80.

28. Martínez-Biarge M., Diez-Sebastián J., Kapellou O., Gindner D., Allsop JM., Rutherford MA., et al. Predicting motor outcome and death in term hypoxic-ischemic encephalopathy. Neurology. 2011; 76(24): 2055-61.

29. Martínez-Biarge M., Diez-Sebastián J., Rutherford MA., Cowan FM. Outcomes after central grey matter injury in term perinatal hypoxic-ischaemic encephalopathy. Early Hum Dev. 2010; 86(11): 675-82.

30. Ramaswamy V., Horton J., Vandermeer B., Buscemi N., Miller S., Yager J. Systematic review of biomarkers of brain injury in term neonatal encephalopathy. Pediatr Neurol. 2009; 40(3): 215-26.

31. Gluckman PD., Wyatt JS., Azzopardi D., Ballard R., Edwards AD., Ferriero DM., et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet. 2005; 365(9460): 663-70.

32. Shankaran S., Laptook AR., Ehrenkranz RA., Tyson JE., McDonald SA., Donovan EF., et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med. 2005; 353(15): 1574-84.

33. Eicher DJ., Wagner CL., Katikanemi LP. Moderate hypothermia in neonatal encephalopathy: safety outcomes. Pediatr Neurol. 2005; 32(1): 18-24.

34. Azzopardi DV., Strohm B., Edwards AD., Dyet L., Halliday HL., Juszczak E., et al; TOBY Study Group. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med. 2009; 361(14): 1349-58.

35. Edwards AD., Azzopardi DV. Therapeutic hypothermia following perinatal asphyxia. Arch Dis Child Fetal Neonatal Ed. 2006; 91(2): F127-31.

36. Jacobs SE., Morley CJ., Inder TE., Stewart MJ., Smith KR., McNamara PJ., et al. Infant Cooling Evaluation Collaboration. Whole-body hypothermia for term and near term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial. Arch Pediatr Adolesc Med. 2011; 165(8): 692-700.

37. Simbruner G., Mittal RA., Rohlmann F., Muche R; neo.nEURO.network Trial Participants. Systemic hypothermia after neonatal encephalopathy: outcomes of neo.nEURO. network RCT. Pediatrics. 2010; 126(4): e771-8.

38 Zhou WH., Cheng GQ, Shao XM., Liu XZ., Shan RB., Zhuang DY., et al; China Study Group. Selective head cooling with mild systemic hypothermia after neonatal hypoxic-ischemic encephalopathy: a multicenter randomized controlled trial in China. J Pediatr. 2010; 157(3): 367-72.

39. Schulzke SM., Rao S., Patole SK. A systematic review of cooling for neuroprotection in neonates with hypoxic-ischemic encephalopathy-are we there yet? BMC Pediatrics. 2007; 7: 30.

40. Shah PS., Ohlsson A., Perlman M. Hypothermia to treat neonatal hypoxic ischemic encephalopathy. Arch Pediatr Adolesc Med. 2007; 161(10): 951-8.

41. Jacobs S., Hunt R., Tarnow-Mordi W, Inder T., Davis P. Cooling for newborns with hypoxic-ischemic encephalopathy. Cochrane Database Syst Rev. 2007; (4): CD00311.

42. Tagin MA., Woolcott CG., Vincer MJ., Whyte RK., Stinson DA. Hypothermia for neonatal hypoxic ischemic encephalopathy: an updated systematic review and metaanalysis. Arch Pediatr Adolesc Med. 2012; 166(6): 558-66.

43. Blanco D., García-Alix A., Valverde E., Tenorio V., Vento M, Cabañas F; Comisión de Estándares de la Sociedad Española de Neonatología (SEN). Neuroprotección con hipotermia en el recién nacido con encefalopatía hipóxico-isquémica. Guía de estándares para su aplicación clínica. An Pediatr (Barc). 2011; 75(5): 341.e1-20.

44. García-Alix A., González de Dios J. La encefalopatía hipóxico-isquémica en el recién nacido a término ha dejado de ser una entidad huérfana. Implicaciones para la práctica y necesidad de un «codigo hipotermia». Pediatr. 2010; 6(2): 27-30.

45. García-Alix A. Hipotermia cerebral moderada en la encefalopatía hipóxico-isquémica. Un nuevo reto asistencial en neonatología. An Pediatr (Barc). 2009; 71(4): 281-3.

46. National Institute for Health and Clinical Excellence. Therapeutic hypothermia with intracorporeal temperature monitoring for hypoxic perinatal brain injury [Internet]. London: National Institute for Health and Clinical Excellence; 2010. [acceso 29 de abril de 2014]. Disponible en: http://www.nice.org.uk/IPG347

47. Chalak L., Kaiser J. Neonatal Guideline Hypoxic-Ischemic Encephalopathy (HIE). J Ark Med Soc. 2007; 104(4): 87-9.

48. Queensland Maternity and Neonatal Clinical Guidelines Program. Hypoxic-ischaemic encephalopathy [Internet]. Queensland: Queensland Government; 2010 [acceso 29 de abril de 2014]. Disponible en: http://www.health.qld.gov.au/qcg/documents/g_hie5-1. pdf

49. Peliowski-Davidovich A; Canadian Paediatric Society, Fetus and Newborn Committee. Hypothermia for newborns with hypoxic ischemic encephalopathy. Paediatr Child Health. 2012; 17(1): 41-6.

50. Mathur AM., Smith JR., Donze A. Hypothermia and hypoxic-ischemic encephalopathy: guideline development using the best evidence. Neonatal Netw. 2008; 27(4): 271-86.

51. Cortés Casimiro VR., Salinas López MP., Estrada Flores JV., Aguilar Solano AM., Chávez Ramírez AT., Zapata Arenas DM. Guía de práctica clínica. Diagnóstico, tratamiento y pronóstico de la encefalopatía hipóxico-isquémica en el recién nacido: evidencias y recomendaciones [Internet]. México: Centro Nacional de Excelencia Tecnológica en Salud; 2010 [acceso 29 de abril de 2014]. Disponible en:. http://www.cenetec.salud. gob.mx/descargas/gpc/CatalogoMaestro/371-10_Encefalopatxahipoxico-isquxmica/ IMSS-371-10_GER_Encefalopatxa_Hipxxico_Isquxmica.pdf

52. Grupo de trabajo sobre GPC. Elaboración de guías de práctica clínica en el Sistema Nacional de Salud. Manual metodológico [Internet]. Madrid: Plan Nacional para el SNS. Instituto Aragonés de Ciencias de la Salud-I+CS. Ministerio de Sanidad y Consumo; 2007. Nº2006/01 [acceso 22 de febrero de 2012] Disponible en: http://portal. guiasalud.es/emanuales/elaboracion/documentos/
Manual%20metodologico%20-%20Elaboracion%20GPC%20en%20el%20SNS.pd

53. López Bastida J., Oliva J., Antoñaranzas F., García-Altés A., Gisbert R., Mar J., et al. Propuesta de guía para la evaluación económica aplicada a las tecnologías sanitarias. Gac Sanit. 2010; 24(2): 154-70.

54. Brouwers M., Kho ME., Browman GP., Burgers JS., Cluzeau F., Feder G., et al; AGREE Next Steps Consortium. AGREE II: Advancing guideline development, reporting and evaluation in health care. CMAJ. 2010;182(18):e839-42.

55. National Collaborating Centre for Methods and Tools. AMSTAR: assessing methodological quality of systematic reviews [Internet]. Hamilton: McMaster University; 2007 [acceso 29 de abril de 2014]. Disponible en: http://www.nccmt.ca/registry/view/eng/97.html

56. Martín Muñoz P., González de Dios J. Valoración de la calidad de la evidencia y fuerza de las recomendaciones (I) El sistema GRADE. Evid Pediatr. 2010; 6: 63.

57. Martín Muñoz P., González de Dios J. Valoración de la calidad de la evidencia y fuerza de las recomendaciones (I) Consideraciones prácticas en la aplicación del Sistema GRADE. Evid Pediatr. 2010; 6: 91.

58. Davis PG., Tan A., O’Donnell CP., Schulze A. Resuscitation of newborn infants with 100% oxygen or air: a systematic review and meta-analysis. Lancet. 2004; 364(9442): 1329-33.

59. Tan A., Schulze A., O’Donnell CP., Davis PG. Air versus oxygen for resuscitation of infants at birth. Cochrane Database Syst Rev. 2005; 18(2): CD002273.

60. Saugstad OD., Ramji S., Vento M. Resuscitation of depressed newborn infants with ambient air or pure oxygen: a meta-analysis. Biol Neonate. 2005; 87(1): 27-34.

61. Rabi Y., Rabi D., Yee W. Room air resuscitation of the depressed newborn: a systematic review and meta-analysis. Resuscitation. 2007; 72(3): 353-63.

62. Saugstad OD., Ramji S., Soll RF., Vento M. Resuscitation of newborn infants with 21% or 100% oxygen: an updated systematic review and meta-analysis. Neonatology. 2008; 94(3): 176-82.

63. Vento M., Asensi M., Sastre J., García-Sala F., Viña J. Six years of experience with the use of room air for the resuscitation of asphyxiated newly born term infants. Biol Neonate. 2001; 79(3-4): 261-7.

64. Saugstad OD., Rootwelt T., Aalen O. Resuscitation of asphyxiated newborn infants with room air or oxygen: an international controlled trial: the Resair 2 study. Pediatrics. 1998; 102(1): e1.

65. Saugstad OD., Vento M., Ramji S., Howard D., Soll RF. Neurodevelopmental outcome of infants resuscitated with air or 100% oxygen: a systematic review and meta-analysis. Neonatology. 2012; 102(2): 98-103.

66. Perlman JM., Wyllie J., Kattwinkel J., Atkins DL., Chameides L., Goldsmith JP., et al; Neonatal Resuscitation Chapter Collaborators. Part 11: Neonatal resuscitation: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation. 2010; 122(16 Suppl 2): S516-38.

67. Harrington DJ., Redman CW, Moulden M., Greenwood CE. The long-term outcome in surviving infants with Apgar zero at 10 minutes: a systematic review of the literature and hospital-based cohort. Am J Obstet Gynecol. 2007; 196(5): 463.e1-5.

68. Laptook AR., Shankaran S., Ambalavanan N., Carlo WA., McDonald SA., Higgins RD., et al. Hypothermia Subcommittee of the NICHD Neonatal Research Network. Outcome of term infants using Apgar scores at 10 minutes following hypoxic-ischemic encephalopathy. Pediatrics. 2009; 124(6): 1619-26.

69. Laptook A., Tyson J., Shankaran S., McDonald S., Ehrenkranz R., Fanaroff A., et al; National Institute of Child Health and Human Development Neonatal Research Network. Elevated temperature after hypoxic-ischemic encephalopathy: risk factor for adverse outcomes. Pediatrics. 2008; 122(3): 491-9.

70. Tam EW, Haeusslein LA., Bonifacio SL., Glass HC., Rogers EE., Jeremy RJ., et al. Hypoglycemia is associated with increased risk for brain injury and adverse neurodevelopmental outcome in neonates at risk for encephalopathy. J Pediatr. 2012; 161(1): 88-93.

71. Klinger G., Beyene J., Shah P., Perlman M. Do hyperoxaemia and hypocapnia add to the risk of brain injury after intrapartum asphyxia? Arch Dis Child Fetal Neonatal Ed. 2005; 90(1): F49-52.

72. Nadeem M., Murray D., Boylan G., Dempsey EM., Ryan CA. Blood carbon dioxide levels and adverse outcome in neonatal hypoxic-ischemic encephalopathy. Am J Perinatol. 2010; 27(5): 361-5.

73. Pappas A., Shankaran S., Laptook AR., Langer JC., Bara R., Ehrenkranz RA., et al; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Hypocarbia and adverse outcome in neonatal hypoxicischemic encephalopathy. J Pediatr. 2011; 158(5): 752-8.e1.

74. Nadeem M., Murray DM., Boylan GB., Dempsey EM., Ryan CA. Early blood glucose profile and neurodevelopmental outcome at two years in neonatal hypoxic-ischaemic encephalopathy. BMC Pediatr. 2011; 4(11): 10.

75. Basu P., Som S., Choudhuri N., Das H. Contribution of the blood glucose level in perinatal asphyxia. Eur J Pediatr. 2009; 168(7): 833-88.

76. Salhab WA., Wyckoff MH., Laptook AR., Perlman JM. Initial hypoglycemia and neonatal brain injury in term infants with severe fetal acidemia. Pediatrics. 2004; 114(2): 361-6.

77. Edwards AD., Brocklehurst P., Gunn AJ., Halliday H., Juszczak E., Levene M., et al. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data. BMJ. 2010; 9(340): c363.

78. Shah PS. Hypothermia: a systematic review and meta-analysis of clinical trials. Semin Fetal Neonatal Med. 2010; 15(5): 238-46.

79. Gunn AJ., Gluckman PD., Gunn TR. Selective head cooling in newborn infants after perinatal asphyxia: a safety study. Pediatrics. 1998; 102(4 Pt 1): 885-92.

80. Shankaran S., Laptook A., Wright LL., Ehrenkranz RA., Donovan EF., Fanaroff AA., et al. Whole-body hypothermia for neonatal encephalopathy: animal observations as a basis for a randomized, controlled pilot study in term infants. Pediatrics. 2002; 110(2 Pt 1): 377-85.

81. Zhou WH., Shao XM., Cao Y., Chen C., Zhang XD. Safety study of hypothermia for treatment of hypoxic-ischemic brain damage in term neonates. Acta Pharmacol Sin. 2002; 23S: 64-8.

82. Akisu M., Huseyinov A., Yalaz M., Cetin H., Kultursay N. Selective head cooling with hypothermia suppresses the generation of platelet-activating factor in cerebrospinal fluid of newborn infants with perinatal asphyxia. Prostaglandins Leukot Essent Fatty Acids. 2003; 69(1): 45-50.

83. Inder TE., Hunt RW, Morley CJ., Coleman L., Stewart M., Doyle LW, et al. Randomized trial of systemic hypothermia selectively protects the cortex on MRI in term hypoxic-ischemic encephalopathy. J Pediatr. 2004; 145(6): 835-7.

84. Eicher DJ., Wagner CL., Katikaneni LP., Hulsey TC., Bass WT., Kaufman DA., et al. Moderate hypothermia in neonatal encephalopathy: efficacy outcomes. Pediatr Neurol. 2005; 32(1): 11-7.

85. Bhat MA. Re: Therapeutic hypothermia following perinatal asphyxia. Arch Dis Child Fetal Neonatal Ed. 2006; 91(6): F464.

86. Lin ZL., Yu HM., Lin J., Chen SQ, Liang ZQ, Zhang ZY. Mild hypothermia via selective head cooling as neuroprotective therapy in term neonates with perinatal asphyxia: an experience from a single neonatal intensive care unit. J Perinatol. 2006; 26(3): 180-4.

87. Robertson NJ., Nakakeeto M., Hagmann C., Cowan FM., Acolet D., Iwata O., et al. Therapeutic hypothermia for birth asphyxia in low-resource settings: a pilot randomised controlled trial. Lancet. 2008; 372(9641): 801-3.

88. Li T., Xu F., Cheng X., Guo X., Ji L., Zhang Z., et al. Systemic hypothermia induced within 10 hours after birth improved neurological outcome in newborns with hypoxicischemic encephalopathy. Hosp Pract (Minneap). 2009; 37(1): 147-52.

89. Guillet R., Edwards AD., Thoresen M, Ferriero DM, Gluckman PD., Whitelaw A., et al. Seven- to eight-year follow-up of the CoolCap trial of head cooling for neonatal encephalopathy. Pediatr Res. 2012; 71(2): 205-9.

90. Shankaran S., Pappas A., McDonald SA., Vohr BR., Hintz SR., Yolton K., et al. Childhood outcomes after hypothermia for neonatal encephalopathy. N Engl J Med. 2012; 31(366): 2085-92.

91. Gray J., Geva A., Zheng Z., Zupancic JA. CoolSim: using industrial modeling techniques to examine the impact of selective head cooling in a model of perinatal regionalization. Pediatrics. 2008; 121(1): 28-36.

92. Horn A., Thompson C., Woods D., Nel A., Bekker A., Rhoda N., et al. Induced hypothermia for infants with hypoxic- ischemic encephalopathy using a servo-controlled fan: an exploratory pilot study. Pediatrics. 2009; 123(6): e1090-8.

93. Regier DA., Petrou S., Henderson J., Eddama O., Patel N., Strohm B., et al. Cost-effectiveness of therapeutic hypothermia to treat neonatal encephalopathy. Value Health. 2010; 13(6): 695-702.

94. Geva A., Gray J. A quantitative analysis of optimal treatment capacity for perinatal asphyxia. Med Decis Making. 2012; 32(2): 266-72.

95. Wyatt JS., Gluckman PD., Liu PY., Azzopardi D., Ballard R., Edwards AD., et al; CoolCap Study Group. Determinants of outcomes after head cooling for neonatal encephalopathy. Pediatrics. 2007; 119(5): 912-21.

96. Pin TW, Eldridge B., Galea MP. A review of developmental outcomes of term infants with post-asphyxia neonatal encephalopathy. Eur J Paediatr Neurol. 2009; 13(3): 224- 34.

97. McShane M., Maguire S., McClure G., Halliday H., McC Reid M. Birth asphyxia, encephalopathy and outcome. Ir Med J. 1987; 80(12): 421-2.

98. Gray PH., Tudehope DI., Masel JP., Burns YR., Mohay HA., O’Callaghan MJ., et al. Perinatal hypoxic-ischaemic brain injury: prediction of outcome. Dev Med Child Neurol. 1993; 35(11): 965-73.

99. Yudkin PL., Johnson A., Clover LM., Murphy KW. Clustering of perinatal markers of brain asphyxia and outcome at age five years. Br J Obstet Gynaecol. 1994; 101(9): 774-81.

100. Handley-Derry M., Low JA., Burke SO., Waurick M., Killen H., Derrick EJ. Intrapartum fetal asphyxia and the occurrence of minor deficits in 4 to 8-year-old children. Dev Med Child Neurol. 1997; 39(8): 508-14.

101. Hallioglu O., Topaloglu AK., Zenciroglu A., Duzovali O., Yilgor E., Saribas S. Denver developmental screening test II for early identification of the infants who will develop major neurological defecit as a sequalea of hypoxic-ischemic encephalopathy. Pediatr Int. 2001; 43(4): 400-4.

102. Carli G., Reiger I., Evans N. One-year neurodevelopmental outcome after moderate newborn hypoxic ischaemic encephalopathy. J Paediatr Child Health. 2004; 40(4): 217- 20.

103. van Schie PE., Becher JG., Dallmeijer AJ., Barkhof F., Van Weissenbruch MM, Vermeulen RJ. Motor testing at 1 year improves the prediction of motor and mental outcome at 2 years after perinatal hypoxic-ischaemic encephalopathy. Dev Med Child Neurol. 2010; 52(1): 54-9.

104. Gunn AJ., Wyatt JS., Whitelaw A., Barks J., Azzopardi D., Ballard R., et al. Therapeutic hypothermia changes the prognostic value of clinical evaluation of neonatal encephalopathy. J Pediatr. 2008; 152(1): 55-8.

105. Shankaran S., Laptook AR., Tyson JE., Ehrenkranz RA., Bann CA., Das A., et al. Evolution of encephalopathy during whole body hypothermia for neonatal hypoxicischemic encephalopathy. J Pediatr. 2012; 160(4): 567-72.

106. Chaudhari T., McGuire W. Allopurinol for preventing mortality and morbidity in newborn infants with suspected hypoxic-ischaemic encephalopathy. Cochrane Database of Systematic Reviews. 2008; 16(2): CD006817.

107. Gunes T., Ozturk MA., Koklu E., Kose K., Gunes I. Effect of allopurinol supplementation on nitric oxide levels in asphyxiated newborns. Pediatr Neurol. 2007; 36(1): 17-24.

108. van Bel F., Shadid M., Moison RM., Dorrepaal CA., Fontijn J., Monteiro L., et al. Effect of allopurinol on postasphyxial free radical formation, cerebral hemodynamics and electrical brain activity. Pediatrics. 1998; 101(2): 185-93.

109. Benders MJ., Bos AF., Rademaker CM., Rijken M., Torrance HL., Groenendaal F., et al. Early postnatal allopurinol does not improve short term outcome after severe birth asphyxia. Arch Dis Child Fetal Neonatal Ed. 2006; 91(3): F163-5.

110. Kaandorp JJ., van Bel F., Veen S., Derks JB., Groenendaal F., Rijken M., et al. Longterm neuroprotective effects of allopurinol after moderate pernatal asphyxia: followupo of two randomised controlled trials. Arch Dis Child Fetal Neonatal Ed. 2012; 97(3): F162-6.

111. Zhu C., Kang W, Xu F., Cheng X., Zhang Z., Jia L., et al. Erythropoietin improved neurologic outcomes in newborns with hypoxic-ischemic encephalopathy. Pediatrics. 2009; 124(2): e218-26.

112. Elmahdy H., El-Mashad AR., El-Bahrawy H., El-Gohary T., El-Barbary A., Aly H. Human Recombinant Erythropoietin in asphyxia neonatorum: pilot trial. Pediatrics. 2010; 125(5): e1135-42.

113. Singh D., Kumar P., Narang A. A randomized controlled trial of phenobarbital in neonates with hypoxic ischemic encephalopathy. J Matern Fetal Neonatal Med. 2005; 18(6): 391-5.

114. Filippi L., Poggi C., La Marca G., Furlanetto S., Fiorini P., Cavallaro G., et al. Oral topiramate in neonates with hypoxic ischemic encephalopathy treated with hypothermia: a safety study. J Pediatr. 2010; 157(3): 361-6.

115. Wu YW, Bauer LA., Ballard RA., Ferriero DM., Glidden DV., Mayock DE., et al. Erytropoietin for neuroprotection in neonatal encephalopathy: safety and pharmacokinetics. Pediatrics. 2012; 130(4): 683-91.

116. Evans DJ., Levene MI., Tsakmakis M. Anticonvulsants for preventing mortality and morbidity in full term newborns with perinatal asphyxia. Cochrane Database Syst Rev. 2007; 18(3): CD001240.

117. van Rooij LG., Toet MC., van Huffelen AC., Groenendaal F., Laan W, Zecic A., et al. Effect of treatment of subclinical neonatal seizures detected with aEEG: randomized, controlled trial. Pediatrics. 2010; 125(2): e358-66.

118. Wusthoff CJ., Dlugos DJ., Gutierrez-Colina A., Wang A., Cook N., Donnelli M., et al. Electrographic seizures during therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy. J Child Neurol. 2011; 26(6): 724-8.

119. Hoehn T., Hansmann G., Bührer C., Simbruner G., Gunn AJ., Yager J., et al. Therapeutic hypothermia in neonates. Review of current clinical data, ILCOR recommendations and suggestions for implementation in neonatal intensive care units. Resuscitation. 2008; 78(1): 7-12.

120. Angeles DM., Wycliffe N., Michelson D., Holshouser BA., Deming DD., Pearce WJ., et al. Use of opioids in asphyxiated term neonates: effects on neuroimaging and clinical outcome. Pediatr Res. 2005; 57(6): 873-8.

121. Walsh BH., Murray DM., Boylan GB. The use of conventional EEG for the assesment of hypoxic ischaemic encephalopathy in the newborn: a review. Clin Neurophysiol. 2011; 122(7): 1284-94.

122. Toet MC., Hellström-Westas L., Groenendaal F., Eken P., de Vries LS. Amplitude integrated EEG 3 and 6 hours after birth in full term neonates with hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed. 1999; 81(1): F19-23.

123. Ter Horst HJ., Sommer C., Bergman KA., Fock JM., van Weerden TW, Bos AF. Prognostic significance of amplitude-integrated EEG during the first 72 hours after birth in severely asphyxiated neonates. Pediatr Res. 2004; 55(6): 1026-33.

124. Hellström-Westas L., Rosén I., Svenningsen NW. Predictive value of early continuous amplitude integrated EEG recordings on outcome after severe birth asphyxia in full term infants. Arch Dis Child Fetal Neonatal Ed. 1995; 72(1): F34-8.

125. Al Naqeeb N., Edwards AD., Cowan FM., Azzopardi D. Assessment of neonatal encephalopathy by amplitude integrated electroencephalography. Pediatrics. 1999; 103(6 Pt 1): 1263-71.

126. Thornberg E., Ekström-Jodal B. Cerebral function monitoring: a method of predicting outcome in term neonates after severe perinatal asphyxia. Acta Paediatr. 1994; 83(6): 596-601.

127. van Rooij LG., Toet MC., Osredkar D., van Huffelen AC., Groenendaal F., de Vries LS. Recovery of amplitude integrated electroencephalographic background patterns within 24 hours of perinatal asphyxia. Arch Dis Child Fetal Neonatal Ed. 2005; 90(3): F245-51.

128. Shalak LF., Laptook AR., Velaphi SC., Perlman JM. Amplitude-integrated electroencephalography coupled with an early neurologic examination enhances prediction of term infants at risk for persistent encephalopathy. Pediatrics. 2003; 111(2): 351-7.

129. Shany E., Goldstein E., Khvatskin S., Friger MD., Heiman N., Goldstein M., et al. Predictive value of amplitude-integrated electroencephalography pattern and voltage in asphyxiated term infants. Pediatr Neurol. 2006; 35(5): 335-42.

130. Ancora G., Maranella E., Locatelli C., Pierantoni L., Faldella G. Changes in cerebral hemodynamics and amplitude integrated EEG in an asphyxiated newborn during and after cool cap treatment. Brain Dev. 2009; 31(6): 442-4.

131. Ancora G., Maranella E., Grandi S., Sbravati F., Coccolini E., Savini S., et al. Early predictors of short term neurodevelopmental outcome in asphyxiated cooled infants. A combined brain amplitude integrated electroencephalography and near infrared spectroscopy study. Brain Dev. 2013; 35(1): 26-31.

132. Hallberg B., Grossmann K., Bartocci M., Blennow M. The prognostic value of early aEEG in asphyxiated infants undergoing systemic hypothermia treatment. Acta Paediatr. 2010; 99(4): 531-6.

133. Thoresen M., Hellström-Westas L., Liu X., de Vries LS. Effect of hypothermia on amplitude-integrated electroencephalogram in infants with asphyxia. Pediatrics. 2010; 126(1): e131-9.

134. Shankaran S., Pappas A.,A., McDonald SA., Laptook AR., Bara R., Ehrenkranz RA., et al. Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Predictive value of an early amplitude integrated electroencephalogram and neurologic examination. Pediatrics. 2011; 128(1): e112-20.

135. Gucuyener K., Beken S., Ergenekon E., Soysal S., Hirfanoglu I., Turan O., et al. Use of amplitude-integrated electroencephalography (aEEG) and near infrared spectroscopy findings in neonates with asphyxia during selective head cooling. Brain Dev. 2012; 34(4): 280-6.

136. Murray DM., Ryan CA., Boylan GB., Connolly S. Prediction of seizures in asphyxiated neonates: correlation with continuous video-electroencephalographic monitoring. Pediatrics. 2006; 118(1): 41-6.

137. Takenouchi T., Rubens EO., Yap VL., Ross G., Engel M., Perlman JM. Delayed onset of sleep-wake cycling with favorable outcome in hypothermic-treated neonates with encephalopathy. J Pediatr. 2011; 159(2): 232-7.

138. Sarkar S., Barks JD., Donn SM. Should amplitude-integrated electroencephalography be used to identify infants suitable for hypothermic neuroprotection? J Perinatol. 2008; 28(2): 117-22.

139. Osredkar D., Toet MC., van Rooij LG., van Huffelen AC., Groenendaal F., de Vries LS. Sleep-wake cycling on amplitude-integrated electroencephalography in term newborns with hypoxic-ischemic encephalopathy. Pediatrics. 2005; 115(2): 327-32.

140. Ancora G., Soffritti S., Lodi R., Tonon C., Grandi S., Locatelli C., et al. A combined a-EEG and MR spectroscopy study in term newborns with hypoxic-ischemic encephalopathy. Brain Dev. 2010; 32(10): 835-42.

141. Leijser LM., Vein AA., Liauw L., Strauss T., Veen S., Wezel-Meijler GV. Prediction of short-term neurological outcome in full-term neonates with hypoxic-ischaemic encephalopathy based on combined use of electroencephalogram and neuro-imaging. Neuropediatrics. 2007; 38(5): 219-27.

142. Murray DM., Boylan GB., Ryan CA., Connolly S. Early EEG findings in hypoxic ischemic encephalopathy predict outcomes at 2 years. Pediatrics. 2009; 124(3): e459-67.

143. Flisberg A, Kjellmer I., Löfhede J., Lindecrantz K., Thordstein M. Prognostic capacity of automated quantification of suppression time in the EEG of post-asphyctic full-term neonates. Acta Paediatr. 2011; 100(10): 1338-43.

144. Wertheim D., Mercuri E., Faundez JC., Rutherford M., Acolet D., Dubowitz L. Prognostic value of continuous electroencephalographic recording in full term infants with hypoxic ischaemic encephalopathy. Arch Dis Child. 1994; 71(2): F97-102.

145. Azzopardi D., Guarino I., Brayshaw C., Cowan F., Price-Williams D., Edwards AD., et al. Prediction of neurological outcome after birth asphyxia from early continuous two-channel electroencephalography. Early Hum Dev. 1999; 55(2): 113-23.

146. Shany E., Benzaqen O., Watemberg N. Comparison of continuous drip of midazolam or lidocaine in the treatment of intractable neonatal seizures. J Child Neurol. 2007; 22(3): 255-9.

147. Mandel R., Martinot A., Delepoulle F., Lamblin MD., Laureau E., Vallee L., et al. Prediction of outcome after hypoxic-ischemic encephalopathy: a prospective clinical and electrophysiologic study. J Pediatr. 2002; 141(1): 45-50.

148. Hathi M., Sherman DL., Inder T., Rothman NS., Natarajan M., Niesen C., et al. Quantitative EEG in babies at risk for hypoxic ischemic encephalopathy after perinatal asphyxia. J Perinatol. 2010; 30(2): 122-6.

149. Nash KB., Bonifacio SL., Glass HC., Sullivan JE., Barkovich AJ., Ferriero DM., et al. Video-EEG monitoring in newborns with hypoxic-ischemic encephalopathy treated with hypothermia. Neurology. 2011; 76(6): 556-62.

150. Hamelin S., Delnard N., Cneude F., Debillon T., Vercueil L. Influence of hypothermia on the prognostic value of early EEG in full-term neonates with hypoxic ischemic encephalopathy. Neurophysiol Clin. 2011; 41(1): 19-27.

151. Lamblin MD., Andréb M. Électroencéphalogramme du nouveau-né à terme. Aspects normaux et encephalopathy hypoxo-ischémique. Neurophysiol Clin. 2011; 41(1): 1-18.

152. Lamblin MD., Racoussot S., Pierrat V., Duquennoy C., Ouahsine T., Lequien P., et al. Encéphalopathie anoxo-ischénique du nouveau-né à terme. Apport de l’électroencephalogramme et de l’échographie transfontanellaire à l’évaluation pronostique. À propos de 29 observations. Neurophysiol Clin. 1996; 26(6): 369-78.

153. Gire C., Nicaise C., Roussel CM., Soula F., Girard G., Somma-Mauvais G., et al. Encéphalopathie hypixo-ischémique du nouveau-né à terme. Apport de l’électroencéphalogramme et de l’IRM ou de la TDM à l’évaluation pronostique. À propos de 26 observations. Neurophysiol Clin. 2000; 30(2): 97-107.

154. Selton D., Andre M. Prognosis of Hipoxic-Ischaemic encephalopathy in full term newborns. Value of neonatal electroencephalography. Neuropediatrics. 1997; 28(5): 276-80.

155. Biagioni E., Mercuri E., Rutherford M., Cowan F., Azzopardi D., Frisone MF., et al. Combined use of electroencephalogram and magnetic resonance imaging in full-term neonates with acute encephalopathy. Pediatrics. 2001; 107(3): 461-8.

156. Baumgart S., Graziani LJ. Predicting the future for term infants experiencing an acute neonatal encephalopathy: electroencephalogram, magnetic resonance imaging, or crystal ball? Pediatrics. 2001; 107(3): 588-9.

157. Toet MC., Lemmers PM., van Schelven LJ., van Bel F. Cerebral oxygenation and electrical activity after birth asphyxia: their relation to outcome. Pediatrics. 2006; 117(2): 333-9.

158. Rafay MF., Cortez MA., de Veber GA., Tan-Dy C.,C., Al-Futaisi A., Yoon W, et al. Predictive value of clinical and EEG features in the diagnosis of stroke and hypoxic ischemic encephalopathy in neonates with seizures. Stroke. 2009; 40(7): 2402-7.

159. van Rooij LG., de Vries LS., Handryastuti S., Hawani D., Groenendaal F., van Huffelen AC., et al. Neurodevelopmental outcome in term infants with status epilepticus detected with amplitude-integrated electroencephalography. Pediatrics. 2007; 120(2): e354-6.

160. Mariani E., Scelsa B., Pogliani L., Introvini P., Lista G. Prognostic value of electroencephalograms in asphyxiated newborns treated with hypothermia. Pediatr Neurol. 2008; 39(5): 317-24.

161. Doyle OM., Temko A., Murray DM., Lightbody G., Marnane W, Boylan GB. Predicting the neurodevelopmental outcome in newborns with hypoxic-ischaemic injury. Conf Proc IEEE Eng Med Biol Soc. 2010: 1370-3.

162. Massaro AN., Tsuchida T., Kadom N., El-Dib M., Glass P., Baumgart S. aEEG Evolution during therapeutic hypothermia and prediction of NICU outcome in encephalopathic neonates. Neonatology. 2012; 102(3): 197-202.

163. Vasilijevic B., Maglajic-Djukic S., GojnicM. Prognostic value of amplitude-integrated electroencephalography in neonates with hypoxic-ischemic encephalopathy. Vojnosanit Pregl. 2012; 69(6): 492-9.

164. Coats JS., Freeberg A., Pajela EG., Obenaus A., Ashwal S. Meta-analysis of apparent diffusion coefficients in the newborn brain. Pediatr Neurol. 2009; 41(4): 263-74.

165. Thayyil S., Chandrasekaran M., Taylor A., Bainbridge A., Cady EB., Chong WK., et al. Cerebral magnetic resonance biomarkers in neonatal encephalopathy: a meta-analysis. Pediatrics. 2010; 125(2): e382-95.

166. Wilkinson D. MRI and withdrawal of life support from newborn infants with hypoxicischemic encephalopathy. Pediatrics. 2010; 126(2): e451-8.

167. Kuenzle C., Baenziger O., Martin E., Thun-Hohenstein L., Steinlin M., Good M., et al. Prognostic value of early MR imaging in term infants with severe perinatal asphyxia. Neuropediatrics. 1994; 25(4): 191-200.

168. Rutherford M., Pennock J., Schwieso J., Cowan F., Dubowitz L. Hypoxic-ischaemic encephalopathy: early and late magnetic resonance imaging findings in relation to outcome. Arch Dis Child Fetal Neonatal Ed. 1996; 75(3): F145-51.

169. Rutherford M., Pennock JM., Counsell SJ., Mercuri E., Cowan F., Dubowitz L., et al. Abnormal magnetic resonance signal in the internal capsule predicts poor neurodevelopmental outcome in infants with hypoxic-ischemic encephalopathy. Pediatrics. 1998; 102(2 Pt 1): 323-8.

170. Mercuri E., Ricci D., Cowan FM., Lessing D., Frisone MF., Haataja L., et al. Head growth in infants with hypoxic-ischemic encephalopathy: correlation with neonatal magnetic resonance imaging. Pediatrics. 2000; 106(2 Pt 1): 235-43.

171. Gire C., Nicaise C., Roussel M., Soula F., Girard N., Somma-Mauvais H., et al. Hypoxic-ischemic encephalopathy in the full-term newborn. Contribution of electroencephalography and MRI or computed tomography to its prognostic evaluation. Apropos of 26 cases. Neurophysiol Clin. 2000; 30(2): 97-107.

172. Robertson NJ., Lewis RH., Cowan FM., Allsop JM., Counsell SJ., Edwards AD., et al. Early increases in brain myo-inositol measured by proton magnetic resonance spectroscopy in term infants with neonatal encephalopathy. Pediatr Res. 2001; 50(6): 692-700.

173. Barnett A., Mercuri E., Rutherford M., Haataja L., Frisone MF., Henderson S., et al. Neurological and perceptual-motor outcome at 5-6 years of age in children with neonatal encephalopathy: relationship with neonatal brain MRI. Neuropediatrics. 2002; 33(5): 242-8.

174. Khong PL., Tse C., Wong IY., Lam BC., Cheung PT., Goh WH., et al. Diffusionweighted imaging and proton magnetic resonance spectroscopy in perinatal hypoxicischemic encephalopathy: association with neuromotor outcome at 18 months of age. J Child Neurol. 2004; 19(11): 872-81.

175. Belet N., Belet U., Incesu L., Uysal S., Ozinal S., Keskin T., et al. Hypoxic-ischemic encephalopathy: correlation of serial MRI and outcome. Pediatr Neurol. 2004; 31(4): 267-74.

176. Boichot C., Walker PM., Durand C., Grimaldi M., Chapuis S., Gouyon JB., et al. Term neonate prognoses after perinatal asphyxia: contributions of MR imaging, MR spectroscopy, relaxation times, and apparent diffusion coefficients. Radiology. 2006; 239(3): 839-48.

177. Jyoti R., O’Neil R., Hurrion E. Predicting outcome in term neonates with hypoxicischaemic encephalopathy using simplified MR criteria. Pediatr Radiol. 2006; 36(1): 38-42.

178. van Schie PE., Becher JG., Dallmeijer AJ., Barkhof F., Weissenbruch MM., Vermeulen RJ. Motor outcome at the age of one after perinatal hypoxic-ischemic encephalopathy. Neuropediatrics. 2007; 38(2): 71-7.

179. El-Ayouty M., Abdel-Hady H., El-Mogy S., Zaghlol H., El-Beltagy M., Aly H. Relationship between electroencephalography and magnetic resonance imaging findings after hypoxic-ischemic encephalopathy at term. Am J Perinatol. 2007; 24(8): 467-73.

180. Vermeulen RJ., van Schie PE., Hendrikx L., Barkhof F., van Weissenbruch M., Knol DL., et al. Diffusion-weighted and conventional MR imaging in neonatal hypoxic ischemia: two-year follow-up study. Radiology. 2008; 249(2): 631-9.

181. Meyer-Witte S., Brissaud O., Brun M., Lamireau D., Bordessoules M., Chateil JF. Prognostic value of MR in term neonates with neonatal hypoxic-ischemic encephalopath: MRI score and spectroscopy. About 26 cases. Arch Pediatr. 2008; 15(1): 9-23.

182. Twomey E., Twomey A., Ryan S., Murphy J., Donoghue VB. MR imaging of term infants with hypoxic-ischaemic encephalopathy as a predictor of neurodevelopmental outcome and late MRI appearances. Pediatr Radiol. 2010; 40(9): 1526-35.

183. Rutherford M., Ramenghi LA., Edwards AD., Brocklehurst P., Halliday H., Levene M., et al. Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischaemic encephalopathy: a nested substudy of a randomised controlled trial. Lancet Neurol. 2010; 9(1): 39-45.

184. Alderliesten T., de Vries LS., Benders MJ., Koopman C., Groenendaal F. MR imaging and outcome of term neonates with perinatal asphyxia: value of diffusion-weighted MR imaging and H MR spectroscopy. Radiology. 2011; 261(1): 235-42.

185. Polat M, Simsek A., TansugN., Sezer RG., Ozkol M., Baspinar P. Prediction of neurodevelopmental outcome in term neonates with hypoxic-ischemic encephalopathy. Eur J Paediatr Neurol. 2013; 17(3): 288-93.

186. Shankaran S., Barnes PD., Hintz SR., Laptook AR., Zaterka-Baxter KM., McDonald SA., et al. Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Brain injury following trial of hypothermia for neonatal hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed. 2012; 97(6): F398-404.

187. Tusor N., Wusthoff C., Smee N., Merchant N., Arichi T., Allsop JM., et al. Prediction of neurodevelopmental outcome after hypoxic-ischemic encephalopathy treated with hypothermia by diffusion tensor imaging analyzed using tract-based spatial statistics. Pediatr Res. 2012; 72(1): 63-9.

188. Roelants-van Rijn AM., Nikkels PG., Groenendaal F., van Der Grond J., Barth PG., Snoeck I., et al. Neonatal diffusion-weighted MR imaging: relation with histopathology or follow-up MR examination. Neuropediatrics. 2001; 32(6): 286-94.

189. Kadri M., Shu S., Holshouser B., Deming D., Hopper A., Peverini R., et al. Proton magnetic resonance spectroscopy improves outcome prediction in perinatal CNS insults. J Perinatol. 2003; 23(3): 181-5.

190. Ricci D., Guzzetta A., Cowan F., Haataja L., Rutherford M., Dubowitz L., et al. Sequential neurological examinations in infants with neonatal encephalopathy and low apgar scores: relationship with brain MRI. Neuropediatrics. 2006; 37(3): 148-53.

191. Martinez-Biarge M., Bregant T., Wusthoff CJ., Chew AT., Diez-Sebastian J., Rutherford MA., et al. White matter and cortical injury in hypoxic-ischemic encephalopathy: antecedent factors and 2-year outcome. J Pediatr. 2012; 161(5): 799-807.

192. Cheong JL., Coleman L., Hunt RW, Lee KJ., Doyle LW, Inder TE., et al; Infant Cooling Evaluation Collaboration. Prognostic utility of magnetic resonance imaging in neonatal hypoxic-ischemic encephalopathy: substudy of a randomized trial. Arch Pediatr Adolesc Med. 2012; 166(7): 634-40.

193. Bednarek N., Mathur A., Inder T., Wilkinson J., Neil J., Shimony J. Impact of therapeutic hypothermia on MRI diffusion changes in neonatal encephalopathy. Neurology. 2012; 78(18): 1420-7.

194. Nagdyman N., Kömen W, Ko HK., Müller C., Obladen M. Early biochemical indicators of hypoxic-ischemic encephalopathy after birth asphyxia. Pediatr Res. 2001; 49(4): 502-6.

195. Dayioglu O., Atlihan F., Can D., Bak M., Genel F. Value of neuron-specific enolase levels in cerebrospinal fluid in evaluating the prognosis of asphyxiated neonates. J Trop Pediatr. 2002; 48(1): 60-1.

196. Florio P., Luisi S., Bruschettini M., Grutzfeld D., Dobrzanska A., Bruschettini P., et al. Cerebroespinal fluid Activin A meassurement in asphyxiated full-term newborns predicts hypoxic-ischemic encephalopathy. Clin Chem. 2004; 50(12): 2386-9.

197. Florio P., Luisi S., Moataza B., Torricelli M., Iman I., Hala M., et al. High urinary concentrations of activin A in asphyxiated full-term newborns with moderate or severe hypoxic-Ischemic encephalopathy. Clin Chem. 2007; 53(3): 520-2.

198. Florio P., Frigiola A., Battista R., Abdalla Ael H., Gazzolo D., Galleri L., et al. Activin A in asphyxiated full-term newborns with hypoxic-ischemic encephalopathy. Front Biosci (Elite ED). 2010; 2: 36-42.

199. Martins RO., Rotta NT., Portela LV., Souza DO. S100 Protein related neonatal hypoxia. Arq Neuropsiquiatr. 2006; 64(1): 24-9.

200. Gazzolo D., Marinoni E., Di Iorio R., Bruschettini M., Kornacka M., Lituania M., et al. Urinary S100B Protein measurements: a tool for the early identification of hypoxicischemic encephalopathy in asphyxiated full-term infants. Crit Care Med. 2004; 32(1): 131-6.

201. Bashir M., Frigiola A., Iskander I., Said HM., Aboulgar H., Frulio R., et al. Urinary S100A1B y S100BB to predict hypoxic-ischemic encephalopathy at term. Front Biosci. 2009; 1: 560-7.

202. Liu L., Zheng CX., Peng SF., Zhou HY., Su ZY., He L., et al. Evaluation of urinary S100B protein level and lactate/creatine ratio for early diagnosis and prediction of neonatal encephalopathy. Neonatology. 2010; 97(1): 41-4.

203. Massaro AN., Chang T., Kadom N., Tsuchida T., Scafidi J., Glass P., et al. Biomarkers of brain injury in neonatal encephalopathy treated with hypothermia. J Pediatr. 2012; 161(3): 434-40.

204. Ennen CS., Huisman TA., Savage WJ., Northington FJ., Jennings JM., Everett AD., et al. Glial fibrillary acidic protein as a biomarker for neonatal HIE treated with wholebody cooling. Am J Obstet Gynecol. 2011; 205(3): 251.e1-7.

205. Thornberg E., Thiringer K., Hagberg H., Kjellmer I. Neuron specific enolase in asphyxiated newborns: association with encephalopathy and cerebral function monitor trace. Arch Dis Child. 1995; 72(1): F39-42.

206. Blennow M., Sävman K., Ilves P., Thoresen M., Rosengren L. Brain-specific proteins in the cerebrospinal fluid of severely asphyxiated newborn infants. Acta Paediatr. 2001; 90(10): 1171-5.

207. Ezgü FS., Atalay Y., Gücüyener K., Tunç S., Koç E., Ergenekon E., et al. Neuronspecific enolase levels and neuroimaging in asphyxiated term newborns. J Child Neurol. 2002; 17(11): 824-9.

208. Tekgul H., Yalaz M., Kutukculer N., Ozbek S., Kose T., Akisu M., et al. Value of biochemical markers for outcome in term infants with asphyxia. Pediatr Neurol. 2004; 31(5): 326-32.

209. Sun J., Li J., Cheng G., Sha B., Zhou W. Effects of hypothermia on NSE ans S100 protein levels in CSF in neonates following hypoxic/ischemic brain damage. Acta Paediatr. 2012; 101(8): e316-20.

210. VasiljevicB., Maglajlic-DjukicS., GojnicM., StankovicS. The role of oxidative stress in perinatal hypoxic-ischemic brain injury. Srp Arh Celok Lek. 2012; 140(1-2): 35-41.

211. Verdú-Pérez A., Falero MP., Arroyos A., Estévez F., Félix V., López Y., et al. Enolasa específica neuronal sanguínea en neonatos con asfixia perinatal. Rev Neurol. 2001; 32(8): 714-7.

212. Çeltik C., AcunasB., Oner N., Pala O. Neuron-specific enolase as a marker of the severity and outcome of hypoxic-ischemic encephalopathy. Brain Dev. 2004; 26(6): 398-402.

213. Roka A., Kelen D., Halasz J., Beko G., Azzopardi D., Szabo M. Serum S100B and neuron-specific enolase levels in normothermic and hypothermic infants after perinatal asphyxia. Acta Paediatr. 2012; 101(3): 319-23.

214. Nagdyman N., Grimmer I., Scholz T., Muller C., Obladen M. Predictive value of brain-specific proteins in serum for neurodevelopmental outcome after birth asphyxia. Pediatr Res. 2003; 54(2): 270-5.

215. Thorngren-Jerneck K., Herbst A., Amer-WÅhlin I., Marsal K., Alling C. S100 Protein in serum as a prognostic marker for cerebral injury in term newborn infants with hypoxic ischemic encephalopathy. Pediatr Res. 2004; 55(3): 406-12.

216. Murabayasi M., Minato M., Okuhata Y., Makimoto M., Hosono S., Masaoka N., et al. Kinetics of serum S100B in newborns with intracranial lesions. Pediatr Int. 2008; 50(1): 17-22.

217. Gazzolo D., Marinoni E., Di Iorio R., Bruschettini M., Kornacka M., Lituania M., et al. Measurement of urinary S100B Protein Concentrations for the early identification of brain damage in asphyxiated full-term infants. Arch Pediatr Adolesc Med. 2003; 157(12): 1163-8.

218. Gazzolo D., Abella R., Marinoni E., Di Iorio R., Li Volti G., Galvano F., et al. New markers of neonatal neurology. J Matern Fetal Neonatal Med. 2009; 22 Suppl 3: 57-61.

219. Blennow M., Hagberg H., Rosengren C. Glial fibrillary acidic protein in the CSF: A possible indicator of prognosis in full-term asphyxiated newborn infants? Pediatr Res. 1995; 37(3): 260-4.

220. Florio P., Perrone S., Luisi S., Vezzosi P., Longini M, Marzocchi B., et al. Increased plasma concentrations of activin a predict intraventricular hemorrhage in preterm newborns. Clin Chem. 2006; 52(8): 1516-21.

221. Huang CC., Wang ST., Chang YC., Lin KP., Wu PL. Measurement of the urinary lactate:creatinine ratio for the early identification of newborn infants at risk for hypoxic-ischemic encephalopathy. N Engl J Med. 1999; 341(5): 328-35.

222. Oh W, Perritt R., Shankaran S., Merritts M., Donovan EF., Ehrenkranz RA., et al. Association between urinary lactate to creatinine ratio and neurodevelopmental outcome in term infants with hypoxic-ischemic encephalopathy. J Pediatr. 2008; 153(3): 375-8.

223. VasiljevicB., Maglajlic-Djukic S., Gojnic M, Stankovic S., Ignjatovic S., Lutovac D. New insights into the pathogenesis of perinatal hypoxic-ischemic brain injury. Pediatr Int. 2011; 53(4): 454-62.

224. Gazzolo D., Frigiola A., Bashir M., Iskander I., Mufeed H., Aboulgar H., et al. Diagnostic accuracy of S100B urinary testing at birth in full-term asphyxiated newborns to predict neonatal death. PloS One. 2009; 4(2):e4298.

225. Liu L., Zhou HY., Feng ZW, He L., Su ZY. Urinary S100B protein and lactate/creatinine ratio measurements: a tool for the early identification of neonatal hypoxic-ischemic encephalopathy. Zhonghua Er Ke Za Zhi. 2005; 43(8): 564-7.

226. Beharier O., Kahn J., Shusterman E., Sheiner E. S100B-a potential biomarker for early detection of neonatal brain damage following asphyxia. J Mater-Fetal Neonatal Med. 2012; 25(9): 1523-8.

227. Qian J., Zhou D., Wang YW. Umbilical artery blood S100beta protein: a tool for the early identification of neonatal hypoxic-ischemic encephalopathy. Eur J Pediatr. 2009; 168(1): 71-7.

228. García-Alix A., Quero J. Brain-specific proteins as predictors of outcome in asphyxiated term infants. Acta Paediatr. 2001; 90(10): 1103-5.

229. Yang JC., Zhu XL., Li HZ. Relationship between brainstem auditory evoked potential and serum neuron-specific enolase in neonates with asphyxia. Zhongguo Dang Dai Er Ke Za Zhi. 2008; 10(6): 697-700.

230. Dai HQ, Luo YH. Changes of electroencephalographic background patterns and serum neuron specific enolase levels in neonates with hypoxic-ischemic encephalopathy. Zhongguo Dang Dai Er Ke Za Zhi. 2009; 11(3): 173-6.

231. Mukhtarova SN.Значениеопределениянейроспецифическойэнолазывоценке тяжестигипоксически-ишемическойтравмыноворожденногомозга. Georgian Med News. 2010; 181: 49-54.

232. Bracci R., Perrone S., Buonocore G. The timing of neonatal brain damage. Biol Neonate. 2006; 90(3): 145-55.

233. Castro-Gago M., Rodríguez-Núñez A., Novo-Rodríguez MI., Eirís-Puñal J. Parámetros bioquímicos predictivos del daño neuronal en la infancia. Rev Neurol. 2001; 16-30; 32(12): 1141-50.

234. Dennery PA. Predicting neonatal brain injury: are we there yet? Arch Pediatr Adolesc Med. 2003; 157(12): 1151-2.

235. Florio P., Abella R., Marinoni E., Di Iorio R., Li Volti G., Galvano F., et al. Biochemical markers of perinatal brain damage. Front Biosci (Schol Ed). 2010; 2: 47-72.

236. Moresco L., Bellissima V., Colivicchi M., Crivelli S., Guerriero F., Ricotti A., et al. Importanza determinazione dell’enolasi neurospecific in stima della gravità del danno ipossico-ischemico cerebrale neonatale. Minerva Pediatr. 2010; 62(3 Suppl 1): 141-3.

237. Perrone S., Bracci R., Buonocore G. New biomarkers of fetal-neonatal hypoxic stress. Acta Paediatr Suppl. 2002; 91(438): 135-8.

238. Takashima S., Becker LE., Nishimura M., Tanaka J. Developmental changes of glial fibrillary acidic protein and myelin basic protein in perinatal leukomalacia: relationship to a predisposing factor. Brain Dev. 1984; 6(5): 444-50.

239. Hussein MH., Daoud GA., Kakita H., Kato S., Goto T., Kamei M., et al. High cerebrospinal fluid antioxidants and interleukin 8 are protective of hypoxic brain damage in newborns. Free Radic Res. 2010; 44(4): 422-9.

240. Surveillance of Cerebral Palsy in Europe. Surveillance of cerebral palsy in Europe: a collaboration of cerebral palsy surveys and registers. Dev Med Child Neurol. 2000; 42(12): 816-24.

241. Palisano RJ., Cameron D., Rosenbaum PL., Walter SD., Russell D. Stability of the Gross Motor Function Classification System. Dev Med Child Neurol. 2006; 48(6): 424-8.

242. Palisano R., Rosenbaum P., Walter S., Russell D., Wood E., Galuppi B. Development and reliability of a system to classify gross motor function in children with cerebral palsy. Dev Med Child Neurol. 1997; 39(4): 214-23.

243. Himmelmann K., Beckung E., Hagberg G., Uvebrant P. Gross and fine motor function and accompanying impairments in cerebral palsy. Dev Med Child Neurol 2006; 48(6): 417-23.

244. Fauconnier J., Dickinson HO., Beckung E., Marcelli M., McManus V., Michelsen SI et al. Participation in life situations of 8-12 year old children with cerebral palsy: cross sectional European study. BMJ. 2009; 338: b1458.

245. Vargus-Adams J. Health-related quality of life in childhood cerebral palsy. Arch Phys Med Rehabil. 2005; 86(5): 940-5.

246. Himmelmann K., Hagberg G., Viklund LM., Eek MN., Uvebrant P. Dyskinetic cerebral palsy: a population-based study of children born between 1991 and 1998. Dev Med Child Neurol. 2007; 49(4): 246-51.

247. Gordon GS., Simkiss DE. A systematic review of the evidence for hip surveillance in children with cerebral palsy. J Bone Joint Surg Br. 2006; 88(11): 1492-6.

248. Martínez-Biarge M., Diez-Sebastián J., Wusthoff CJ., Lawrence S., Aloysius A., Rutherford MA., et al. Feeding and communication impairments in infants with central grey matter lesions following perinatal hypoxic-ischaemic injury. Eur J Paediatr Neurol. 2012; 16(6): 688-96.

249. Sullivan PB., Lambert B., Rose M., Ford-Adams M., Johnson A., Griffiths P. Prevalence and severity of feeding and nutritional problems in children with neurological impairment: Oxford feeding study. Dev Med Child Neurol. 2000; 42(10): 674-80.

250. Parkes J., Hill N., Platt MJ., Donnelly C. Oromotor dysfunction and communication impairments in children with cerebral palsy: a register study. Dev Med Child Neurol. 2010; 52(12): 1113-9.

251. Marchand V., Canadian Paediatric Society, Nutrition and Gastroenterology Committee. Nutrition in neurologically impaired children. Paediatr Child Health. 2009; 14(6): 395-401.

252. Craig GM., Scambler G., Spitz L. Why parents of children with neurodevelopmental disabilities requiring gastrostomy feeding need more support. Dev Med Child Neurol. 2003, 45(3): 183-8.

253. Sullivan PB., Juszczak E., Bachlet AM., Thomas AG., Lambert B., Vernon-Roberts A., et al. Impact of gastrostomy tube feeding on the quality of life of carers of children with cerebral palsy. Dev Med Child Neurol. 2004; 46(12): 796-800.

254. Petersen MC., Kedia S., Davis P., Newman L., Temple C. Eating and feeding are not the same: caregivers’ perceptions of gastrostomy feeding for children with cerebral palsy. Dev Med Child Neurol. 2006; 48(9): 713-7.

255. Guerriere DN., McKeever P., Llewellyn-Thomas H., Berall G. Mothers’ decisions about gastrostomy tube insertion in children: factors contributing to uncertainty. Dev Med Child Neurol. 2003; 45(7): 470-6.

256. Fung EB., Samson-Fang L., Stallings VA., Conaway M., Liptak G., Henderson RC., et al. Feeding dysfunction is associated with poor growth and health status in children with cerebral palsy. J Am Diet Assoc. 2002; 102(3): 361-73.

257. Gisel E. Interventions and outcomes for children with dysphagia. Dev Disabil Res Rev. 2008; 14(2): 165-73.

258. Craig GM., Carr LJ., Cass H., Hastings RP., Lawson M., Reilly S., et al. Medical, surgical, and health outcomes of gastrostomy feeding. Dev Med Child Neurol. 2006; 48(5): 353-60.

259. Pennington L., Goldbart J., Marshall J. Direct speech and language therapy for children with cerebral palsy: findings from a systematic review. Dev Med Child Neurol. 2005, 47(1): 57–63.

260. Mercuri E., Anker S., Guzzetta A., Barnett AL., Haataja L., Rutherford M., et al. Visual function at school age in children with neonatal encephalopathy and low Apgar scores. Arch Dis Child Fetal Neonatal Ed. 2004; 89(3): F258-62.

261. Mercuri E., Atkinson J., Braddick O., Anker S., Cowan F., Rutherford M., et al. Basal ganglia damage and impaired visual function in the newborn infant. Arch Dis Child Fetal Neonatal Ed. 1997; 77(2): F111-4.

262. Pisani F., Orsini M., Braibanti S., Copioli C., Sisti L., Turco EC. Development of epilepsy in newborns with moderate HIE and neonatal seizures. Brain Dev. 2009; 31(1): 64-8.

263. Glass HC., Hong KJ., Rogers EE., Jeremy RJ., Bonifacio SL., Sullivan JE., et al. Risk factors for epilepsy in children with neonatal encephalopathy. Pediatr Res. 2011; 70(5): 535-40.

264. Gonzalez FF.,F., Miller SP. Does perinatal asphyxia impair cognitive function without cerebral palsy? Arch Dis Child Fetal Neonatal Ed. 2006; 91(6): F454-9.

265. Miller S., Newton N., Ferreiro D., Partridge J., Glidden D., Banwell A. MRS predictors of 30-month outcome following perinatal depression: role of socio-economic factors. Pediatr Res. 2002; 52(1): 71-7.

266. Bayley N. Bayley scales of infant and toddler development. 3rd ed. San Antonio, TX., USA: Psychological Corporation, 2006. Journal of Psychoeducational AssessmentJune. 2007; 25: 180-90.

267. Badawi N., Dixon G., Felix JF.,F., Keogh JM., Petterson B., Stanley FJ., et al. Autism following a history of newborn encephalopathy: more than a coincidence? Dev Med Child Neurol. 2006; 48(2): 85-9.

268. Sarkar S., Bhagat I., Dechert R., Barks JD. Predicting death despite therapeutic hypothermia in infants with hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed. 2010; 95(6): F423-8.

269. Reid SM., Carlin JB., Reddihough DS. Survival of individuals with cerebral palsy born in Victoria, Australia, between 1970 and 2004. Dev Med Child Neurol. 2012; 54(4): 353-60.

270. American Academy of Pediatrics Committee on Fetus and Newborn. Hospital discharge of the high-risk neonate. Pediatrics. 2008; 122(5): 1119-26.

271. Young P., Hamilton R., Hodgett S., Moss M., Rigby C., Jones P., et al. Reducing risk by improving standards of intrapartum fetal care. J R Soc Med. 2001; 94(5): 226-31.

272. Henderson S., Skelton H., Rosenbaum P. Assistive devices for children with functional impairments: impact on child and caregiver function. Dev Med Child Neurol. 2008, 50(2): 89-98.