No administrar plasma o complejos protrombínicos para reversión de los antagonistas de la vitamina K en situaciones que no sean de emergencia (es decir, fuera del entorno de hemorragia grave, hemorragia intracraneal o cirugía de urgencia).

Holbrook A, Schulman S, Witt DM, Vandvik PO, Fish J, Kovacs MJ, Svensson PJ, Veenstra DL, Crowther M, Guyatt GH; American College of Chest Phsysicians. Evidence-based management of anticoagulant therapy: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence Based Clinical Practice Guidelines. Chest 2012;141(Suppl2):es152-s184.

Scottish Intecollegiate Guidelines Network (SIGN). Antithrombotics: indications and management. Edinburgh (UK):2012. Report Nº129 (75pages).

Ortel TL. Perioperative management of patients on chronic antithrombotic therapy. Blood 2012;120(24):4699-705.