No recomendar profilaxis posexposición frente al VIH en situaciones en las que el riesgo de transmisión del virus sea insignificante: caso fuente sin VIH, exposición sexual a caso fuente con carga viral indetectable, exposición a fluidos que no suponen un riesgo (lágrimas, saliva, orina, sudor, esputo, heces, vómito o secreciones nasales, sin sangre visible), contacto de fluidos infectantes sobre piel intacta, mordeduras sin solución de continuidad, arañazo superficial con objetos afilados (incluidas las agujas abandonadas en la calle).

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