No se recomienda utilizar bisfosfonatos para la prevención de metástasis óseas en pacientes con cáncer de próstata.
National Institute for Health Clinical Excellence (NICE) 2014. Prostate cancer: Clinical Practice Guidelines (CG175).
Mason MD, Sydes MR, Glaholm J, Langley RE, Huddart RA, Sokal M, Stott M, Robinson AC, James ND, Parmar MK, Dearnaley DP; Medical Research Council, PR. Oral sodium clodronate for nonmetastatic prostate cancer-results of a randomized double-blind placebo-controlled trial: Medical Research Council PR04 (ISRCTN61384873). J Natl Cancer Inst 2007;99:765-776.