Guía de Práctica Clínica para el Manejo de Pacientes con Trastornos del Espectro Autista en Atención Primaria.

V. resumida | Info. pacientes | Consulta rápida

  1. Introducción
  2. Alcance y objetivos
  3. Metodología
  4. Definición, manifestaciones clínicas y clasificaciones
  5. Criterios diagnósticos
  6. Detección Precoz
  7. Estrategias de manejo de sospecha de TEA en AP
  8. Aspectos a tener en cuenta al proporcionar información a los padres
  9. Estrategias para el seguimiento de niños con TEA en AP
  10. Difusión e implementación
  11. Líneas propuestas de investigación futura
  12. Bibliografía

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Bibliografía

1. Grupo de Trabajo de Salud Mental PAPPS. Guía de Salud Mental en Atención Primaria. 2001.

2. Informe del Estado de Salud de la Población de la Comunidad de Madrid 2004. Dirección General de Salud Pública y Alimentación. Consejería de Sanidad y Consumo. Comunidad de Madrid. 2005.

3. Estrategia en Salud Mental del Sistema Nacional de Salud. 2006. Ministerio de Sanidad y Consumo. [documento Internet]. [Acceso 1 marzo 2008]. http://www.msc.es/organizacion/sns/planCalidadSNS/pdf/excelencia/salud_mental/
ESTRATEGIA_SALUD_MENTAL_SNS_PAG_WEB.pdf
Abre nueva ventana.

4. Díaz Huertas JA, Vall Combelles O, Ruiz Díaz MA, en colaboración con la Sociedad de Pediatría Social. Informe técnico sobre problemas de salud y sociales de la infancia en España. Ministerio de Sanidad y Consumo. 2006. [documento Internet]. [Acceso 1 marzo 2008]. http://www.agapap.org/datos/problemas%20saludysociales%20informe tecnico.pdf Abre nueva ventana.

5. Federación Estatal de Asociaciones de Profesionales de Atención Temprana (GAT). Libro blanco de la Atención Temprana. Real Patronato de Prevención y de Atención a Personas con Minusvalía. Ministerio de Trabajo y Asuntos Sociales. 2000. http://www.cedd.net/docs/ficheros/200510100001_24_0.pdf Abre nueva ventana

6. López-Ibor JJ, Valdés M, editores. DMS-IV-TR. Manual diagnóstico y estadístico de los trastornos mentales. Texto revisado. Barcelona: Masson; 2002.

7. Seguí JD, Ortiz-Tallo M, De Diego Y. Factores asociados al estrés del cuidador primario de niños con autismo: sobrecarga, psicopatología y estado de salud. anales de psicología. 2008;24:100-105.

8. Barthélémy C, Fuentes J, Howlin P et al. Persons with autism spectrum disorders. Identification, understanding, intervention. Autism-Europe a.i.s.b.l. Association. 2007. [documento Internet]. [Acceso 3 noviembre 2008]. http://www.autismeurope.org/portal/Portals/0/Autism-PWASD.en.pdf Abre nueva ventana

9. Woodgate RL, Ateah C, Secco L. Living in a world of our own: the experience of parents who have a child with autism. Qualitative Health Research. 2008;18:1075-1083.

10. Belinchón M (dir). Situación y necesidades de las personas con trastornos del espectro autista en la Comunidad de Madrid. Obra social Caja Madrid. 2001. http://www.isciii.es/htdocs/centros/enfermedadesraras/pdf/aut_autmad.pdf Abre nueva ventana

11. Cabanyes-Truffino J, García-Villamisar D. Identificación y diagnóstico precoz de los trastornos del espectro autista. Rev Neurol. 2004;39:81-90.

12. Nadel S. Early detection of autism spectrum disorders: screening between 12 adn 24 months of age. Journal of the American Academy of nurse Practtioners. 2007;19:408- 417.

13. Grupo de trabajo sobre GPC. Elaboración de Guías de Práctica Clínica en el Sistema Nacional de Salud. Manual Metodológico. Madrid. Plan Nacional para el SNS del MSC. Instituto Aragonés de Ciencias de la salud-I+CS; 2006. Guías de Práctica Clínica en el SNS: I+CS Nº 2006/0I.

14. Williams JG, Brayne D, Higgins J. Systematic review of prevalence studies of autism spectrum disorders. Archives of Disease in Childhood 2006;91:8-15

15. Fombonne E. Epidemiology of autistic disorder and other pervasive developmental disorders. J Clin Psychiatry 66, 3-8. 2005.

16. Scott FJ, Baron-Cohen S, Bolton P, Brayne C. Brief report Prevalence of autism spectrum conditions in children age 5-11 years in Cambriedgeshire. Autism 2002;6:231-237.

17. Chakrabarti S, Fombonne E. Pervasive Developmental Disorders in Preschool Children: Confirmation of High Prevalence. Am J Psychiatry 2005;162:1133-1141.

18. Bertrand J, Mars A, Boyle C, Bove F, Yeargin-Allsopp M, Decoufle P. Prevalence of Autism in a United States Population: The Brick Township, New Jersey. Investigation Pediatrics. 2001;108(5):1155-61.

19. Tebruegge M, Nandini V, Richie J. Does routine child health surveillance contribute to the early detection of children with pervasive developmental disorders? An epidemiological study in Kent, U.K. BMC Pediatr. 2004 (3);4:4.

20. Fombonne E. The Prevalence of Autism. JAMA. 2003; 289:87-89.

21. Aberdi Mendez JF. Estudio epidemiológico de niños autistas en el Territorio Foral de Navarra. 1991.

22. Capdevila Escude RM. Epidemiología del Síndrome Autista en la Comarca del Valles Occidental. 1994. 23. Sánchez-Valle E, Posada M, Villaverde-Hueso A et al. Estimating the Burden of Disease for Autism Spectrum Disorders in Spain in 2003. J Autism Dev Disord. 2008;38:288-296.

24. Fombonne E. Epidemiology trends in rates of autism. Molecular Psychiatry 2002[S4], S6. 2002.

25. Yeargin-Allsopp M, Rice C, Karapurkar T, Doernberg N, Boyle C, Murphy C. Prevalence of Autism in a US Metropolitan Area. JAMA 289, 49-55. 2003.

26. Zwaigenbaum L, Bryson S, Rogers T et al. Behavioral manifestations of autism in the first year of life. International Journal of Developmental Neuroscience. 2005;23:143-152.

27. Personas con alguna discapacidad que tiene diagnosticado autismo entre los 6-64 años. Encuesta sobre Discapacidades, Deficiencias y Estado de Salud 1999. Instituto Nacional de Estadística (INE). http://www.ine.es/.

28. Ganz ML. The lifetime distribution of the incremental societal costs of autism. Arch Pediatr Adolesc Med. 2007;61:343-349.

29. Croen LA, Najjar DV, Ray GT et al. A comparison of health care utilization and costs of children with and without spectrum disorders in a large group-model health plan. Pediatrics. 2006;118:1203-1211.

30. Grupo de Estudio de los trastornos del Espectro Autista IIER/ISCIII. Encuestas realizadas a familiares de personas con autismo en España: Informe sobre Demora Diagnóstica en los TEA. 2004. Obra Social Cajamadrid. http://www.isciii.es/htdocs/ centros/enfermedadesraras/pdf/aut_isdd.pdf Abre nueva ventana

31. Myers SM, Johnson CP. Management of Children With Autism Spectrum Disorders. American Academy of Pediatrics (Committee on Children with Disabilities). Pediatrics. 2007;120:1162-1182.

32. Cortez Bellotti de Oliveira M, Contreras MM. Diagnóstico precoz de los trastornos del espectro autista en edad temprana (18-36 meses). Arch.Argent.Pediatr. 2007;105: 418-426.

33. American Academy of Pediatrics (Committee on Children with Disabilities). The paediatrician´s role in the diagnosis and management of autistic spectrum disorder in children. Pediatrics. 2001;107:1221-1226.

34. Belinchón M, Hernández JM, Sotillo M. Personas con Síndrome de Asperger. Funcionamiento, detección y necesidades. 2008; Madrid.

35. Howlin P, Asgharian A. The diagnosis of autism and Asperger syndrome: findings from a survey of 770 families. Developmental Medicine & Child Neurology. 1999;41:834-839.

36. Nacional Institute of Mental Health. Autism Spectrum Disorders. 2007. National Institute of Health. U.S. Department of Health and Human Services. http://www.nimh.nih.gov/health/publications/autism/nimhautismspectrum.pdf Abre nueva ventana

37. Crane JL, Winsler A. Early autism deteccion: Implications for pediatric practice and publid policy. Journal of Disability Policy Studies. 2008;18:245-253.

38. Mansell W, Morris K. A survey of parents´ reactions to the diagnosis of an autistic spectrum disorder by a local service: access to information an use of service. Autism. 2004;8:387-407.

39. Dale E, Jahoda A, Knott F. Mothers´ attributions following their child´s diagnosis of autistic spectrum disorder: exploring links with maternal levels of stress, depression and expectations about their child´s future. Autism. 2006;10:463-479.

40. Federación Autismo Castilla y León (FACYL). Proyecto de investigación: La accesibilidad al sistema sanitario de las personas con TEA. 2006.

41. Branson D, Vigil D, Bingham A. Community childcare provider´s role in the early detection of autism spectrum disorders. Early Childhood Education Journal. 2008;35:523-530.

42. Pinto-Martin JA, Souders MC, Giarelli E et al. The role of nurses in screening for autistic spectrum disorder in pediatric primary care. Journal of Pediatric Nursing. 2005;20:163-169.

43. Canal-Bedia R, et al. La detección precoz del autismo. Intervención Psicosocial. 2006;15:29-47.

44. Barbaresi WJ, Katusic SK, Voigt RG. A review of the state of science for pediatric primary health care clinicians. Arch Pediatr Adolesc Med. 2006;160:1167-1175.

45. Millá MG, Mulas F. Atención temprana y programas de intervención específica en el trastorno del espectro autista. Rev Neurol. 2009;48:S47-S52.

46. Ministry of Health and Education. New Zealand Autism Spectrum Disorder Guideline. 2008.

47. Mandell DS NMZC. Factor associated with age of diagnosis among children with autism spectrum disorders. Pediatrics. 2005;116:1480-1486.

48. Fuentes-Biggi J, Ferrari-Arroyo MJ, Boada L et al. (Grupo de Estudio de los Trastornos del Espectro Autista del Instituto de Salud Carlos III. Ministerio de Sanidad y Consumo, España). Guía de buena práctica para el tratamiento de los trastornos del espectro autista. Rev Neurol. 2006;43:425-438.

49. Wing L. The definition and prevalence of autism: a review. European Child and Adolescent Psychiatry. 1993;2:61-74.

50. Just MA, Cherkassky VL, Keller TA et al. Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivity. Brain. 2004;127:1811-1821.

51. Artigas- Pallarés J, Gabau-Vila E, Guitart-Feliubadaló M. El autismo sindrómico: I. Aspectos generales. Rev Neurol. 2005;40(Supl 1): S143-S149.

52. Artigas- Pallarés J, Gabau-Vila E, Guitart-Feliubadaló M. El autismo sindrómico: II. Síndromes de base genética asociados a autismo. Rev Neurol. 2005;40(Supl 1): S151- S162.

53. Díez-Cuervo A. Características clínicas, diagnóstico electroencefalográfico y tratamiento de las crisis epilépticas en las personas autistas. In: Martos J, Rivière A, eds. Autismo: comprensión y explicación actual. Simposium Internacional de Autismo.2001; Madrid: Ministerio de Trabajo y Asuntos Sociales.

54. Díez-Cuervo A. Estado actual de la investigación genética en los trastornos del espectro autista. In: Martos J, González PM, Llorente M et al., eds. Nuevos desarrollos del autismo: el futuro es hoy. IV Simposium Internacional de Autismo.2005; Madrid.

55. Alison Mcinnes L. Una revisión de la genética del autismo. Rev Asoc Esp Neuropsiq. 2002;84:13-24.

56. Risch N, Spiker D, Lotspeich L et al. A genomic screen of autism: Evidence for a multilocus etiology. Am J Hum Genet. 1999;65:493-507.

57. Jones MB, Szatmari P. A risk-factor model of epistatic interaction, focusing on autism. Am J Med Genet. 2002;114:558-565.

58. Ramus F. Genes, Brain and Cognition: A Roadmap for the Cognitive Scientist. Cognition. 2006;101:247-269.

59. Rutter M. Genes and Behavior. 2007; Oxford.

60. Folstein SE, Rosen-Shidley B. Genetics of autism: complex aetiology for a heterogeneous disorder. Nat Rev Genet. 2001;2:943-955.

61. Gillberg C, Coleman M. The Biology of the Austistic Syndromes. 2000; London.

62. Chudley AE, Gutierrez E, Jocelyn LJ et al. Outcomes of genetic evaluation in children with pervasive developmental disorder. J Dev Behav Pediatr. 1998;19:321- 325.

63. Jorde L, Hasstedt S, Ritvo E et al. Complex segregation analysis of autism. Am J Hum Genet. 1991;49:932-938.

64. Rutter M, Silberg J, O´Connor T et al. Genetics and child psychiatry, II Empirical research findings. J Child Psychol Psychiatry. 1999;40:19-55.

65. Bailey A, Palferman S, Heavey L et al. Autism: The phenotype in relatives. J Autism Dev Disord. 1998;28:369-392.

66. Szatmari P, Jones MB, Zwaigenbaum L et al. Genetics of autism: Overview and new directions. J Autism Dev Disord. 1998;28:351-368.

67. Folstein SE, Rutter M. Infantile autism: a genetic study of 21 twin pairs. J Child Psychol Psychiatry. 1977;18:297-321.

68. Ritvo ER, Freeman BJ, Mason-Brothers A et al. Concordance for the syndrome autism in 40 pairs of afflicted twins. Am J Psychiatry. 1985;142:74-77.

69. Stefenburg S, Gillberg C, Hellgren L et al. A twin study of autism in Denmark, Finland, Iceland, Norway, and Sweden. J Child Psychol Psychiatry. 1989;30:405-416.

70. Bailey A, Le Coutier A, Gottesman I et al. Autism as a strongly genetic disorder: evidence from a British twin study. Psychol Med. 1995;25:63-77.

71. Smalley SL, Asarnow RF, Spence MA. Autism and genetics. Arch Gen Psychiaty. 1988;45:953-961.

72. Le Coutier A, Bailey A, Goode S et al. A broader phenotype of autism: the clinical spectrum in twins. J Child Psychol Psychiatry. 1996;37:785-801.

73. Bolton P, Mcdonald H, Pickles A et al. A case-control family history study of autism. J Child Psychol Psychiatry. 1994;35:900.

74. Cook E. Genetics of autism. Child Adolesc Psychiatr Clin N Am. 2001;10:333-350.

75. Fombonne E, Du Mazaubrun C, Cans C et al. Autism and associated medical disorders in a French epidemiological survey. J Am Acad Child Adolesc Psychiatry. 1997;36:1561-1569.

76. Lewis KE, Lubetsky MJ, Wenger SL et al. Chromosomal abnormalities in a psychiatric population. Am J Med Genet. 1995;60:53-54.

77. Wassink TH, Piven J, Patil SR. Chromosomal abnormalities in a clinic sample of individuals with autistic disorders. Psychiatr Genet. 2001;11:57-63.

78. Schroer RJ, Phelan MC, Michaelis RC et al. Autism and maternally derived aberrations of chromosome 15q. Am J Med Genet. 1998;76:727-736.

79. Collaborative Linkage Study of Autism (CLSA). An autosomal genomic screen for autism. Am J Med Genet. 1999;88:609-615.

80. Auranen M, Varilo T, Alen R et al. Evidence for allelic association on chromosome 3q25-27 in families with autism spectrum disorders originating from a subisolate of Finland. Molecular Psychiatry. 2003;8:884.

81. Bakker SC, Van der Meulen EM, Buitelaar JK et al. A whole-genome scan in 1164 Dutch sib pairs with Attention-Deficit/Hyperactivity Disorder: Suggestive Evidene for Linkage on Chromosomes 7p and 15q. Am J Hum Genet. 2003;72:1251-1260.

82. Buxbaum JD, Silverman JM, Smith CJ et al. Evidence for a susceptibility gene for autism on chromosome 2 and for genetic heterogeneity. Am J Hum Genet. 2001;68:1514-1520.

83. Collaborative Linkage Study of Autism (CLSA). Incorporating language phenotypes stregthens evidence of linkage to autism. Am J Med Genet. 2001;105:539-547.

84. Hutcheson HB, Bradford Y, Folstein SE et al. Defining the autism minimum candidate gene region on chromosome 7. Am J Med Genet. 2003;15:90-96.

85. Philippe A, Martinez M, Guilloud-Bataille M et al. Genome-wide scan for autism susceptibility genes. Hum Mol Genet. 1999;8:805-812.

86. Shao Y, Wolpert CM, Raiford KL et al. Genomic screen and follow-up analysis for autismec disorder. Am J Med Genet. 2002;114:99-105.

87. Shao Y, Raiford KL, Wolpert CM et al. Phenotypic homogeneity provides increased support for linkage on chromosome 2 in autistic disorder. Am J Hum Genet. 2002;70:1058-1061.

88. Shao Y, Cuccaro ML, Hauser ER et al. Fine Mapping of autistic disorder to chromosome 15q11-q13 by use of phenotypic subtypes. Am J Hum Genet. 2003;72:539-548.

89. Yonan AL, Alarcón M, Cheng R et al. Genomewide screen of 345 families for autismsusceptibility loci. Am J Hum Genet. 2003;73:886-897.

90. Díez-Cuervo A. Medical disorders and syndromes associated with autism.2000; Madrid.

91. Ruggiere VL, Arberas CL. Behavioural phenotypes. Biologicalment determined neuropsychological patterns. Rev Neurol. 2003;37:239-253.

92. Gillberg C, Forsell C. Childhood psychosis and neurofibromatosis. More than a coincidence? J Autism Dev Disord. 1984;14:1-8.

93. Williams PG, Hersh JG. Brief report The association of neurofibromatosis type 1 and autism. J Autism Dev Disord. 1998;28:567-571.

94. Zappella M. Autism and hypomelanosis of Ito in twins. Dev Med Child Neurology. 1993;35:826-832.

95. Akefeldt A, Gillberg C. Hypomelanosis of Ito in three cases with autism and autisticlike conditions. Dev Med Child Neurology. 1991;33:737-743.

96. Gillberg C, Stefenburg S. Autistic behaviour in Moebious syndrome. Acta Paediatr Scand. 1989;78:314-316.

97. Ozonoff S, Williams BJ, Gales S. Autism and autistic behavior in Joubert syndrome. J Child Neurol. 1999;14:636-641.

98. Kent L, Evans J, Paul M et al. Comorbidity of autistic spectrum disorders in children with Down syndrome. Dev Med Child Neurology. 1999;41:153-158.

99. Ghaziuddin M, Tasai LY, Ghaziuddin N. Autism in Down´s syndrome: presentation and diagnosis. J Intellect Disabil Res. 1992;36:449-456.

100. Reiss AL, Feinstein C, Rosenbaun KN et al. Autism associated with Williams syndrome. J Pediatr. 1985;106:247-249.

101. Morrow JD, Whitman BY, Accardo PJ. Austistic disorder in Sotos syndrome. A case report. Eur J Pediatr. 1990;149:567-569.

102. Komoto J, Usui S, Otsuki S et al. Infantile autism and Duchenne muscular dystrophy. J Autism Dev Disord. 1984;14:191-195.

103. Zwaigenbaum L, Tarnopolsky M. Two children with muscular dystrophies ascertained due to referral for diagnosis of autism. J Autism Dev Disord. 2003;33:193-199.

104. Golfin A, Hoefsloot LH, Bosgoed E et al. PTEN mutation in a family with Cowden syndrome and autism. Am J Med Genet. 2001;105:521-524.

105. Baieli S, Pavone L, Meli C et al. Autism and phenylketonuria. J Autism Dev Disord. 2003;33:204.

106. Miladi N, Lamaout A, Kaabachi N et al. Phenylketonuria: An underlying etiology of autistic syndrome. A case report. J Child Neurol. 1992;7:22-23.

107. Tierney E, Nwokoro NA, Poter FD et al. Behavior phenotype in the RSH/Smith- Lemli-Opitz syndrome. Am J Med Genet. 2001;98:191-200.

108. Stevenson RE, May M, Arena JF et al. Aarskog-Scott syndrome: confirmation of linkage to the pericentromeric region of the X chromosome. Am J Med Genet. 1994;52:339-345.

109. Brodsky MC, Keppen LD, Rice CD et al. Ocular and systemic findings in the Aarskof (facial-digital-genital) syndrome. Am J Ophthalmol. 1990;109:450-456.

110. Fan YS, Farrell SA. Prenatal diagnosis of interstitial deletion of 17(p11.2p11.2) (Smith- Magenis syndrome). Am J Med Genet. 1994;49:253-254.

111. Battaile KP, Battaile BC, Merkens LS et al. Carrier frequency of the common mutation IVS8-IG>C in DHCR7 and estimate of the expected incidence of Smith-Lemli- Opitz syndrome. Mol Genet Metab. 2001;72:67-71.

112. Dixon-Salazar T, Silhavy JL, Marsh SE et al. Mutations in the AHI1 gene, encoding jouberin, cause Joubert syndrome with cortical polymocrogyria. Am J Hum Genet. 2004;75:979-987.

113. Van der Zwaag B, Verzijl HT, Beltran-Valero de Bernabe B et al. Mutation analysis in the candidate Möbius syndrome genes PGT and GATA2 on chromosome 3 and EGR2 on chromosome 10. J Med Genet. 2002;39.

114. Rougeulle C, Glatt H, Lalande M. The Angelman syndrome candidate gene, UBE3A/ E6-AP, is imprinted in brain. Nat Genet. 1997;17:14-15.

115. Gabis L, Pomeroy J, Andriola MR. Autism and epilepsy: cause, consequence, comorbidity, or coincidence? Epilepsy & Behavior. 2005;7:652-656.

116. Riikonen R, Amnell G. Psychiatric disorder in children with earlier infantile spasms. Dev Med Child Neurology. 1981;23:747-760.

117. Tuchman RF, Rapin I, Shinnar S. Autistic and dysphasic children. II: Epilepsy. Pediatrics. 1999;88:1219-1225.

118. Landau WM, Kleffner FR. Syndrome of acquired aphasia with convulsive disorder in children. Neurology. 1957;7:523-530.

119. Beaumanoir A. Le syndrome de Landua-Kleffner. In: Roger J, Dravet C, Bureau M et al., eds. Les syndromes epileptiques de l´enfant et de l´adolescent.1984; Montrouge: John Libbey Eurotext.

120. Cook E. Autism: review of neurochemical investigation. Synapse. 1990;6:292-308.

121. Perry EK, Lee ML, Martin-Ruiz CM et al. Cholinergic activity in autism: abnormalities in the cerebral cortex and basal forebrain. Am J Psychiatry. 2001;158:1058-1066.

122. Braunschweig D, Ashwwood P, Krakowiak P et al. Autism: Maternally derived antibodies specific for fetal brain proteins. NeuroToxicology. 2008;29:226-231.

123. Dalton P, Deacon R, Blamire A et al. Maternal neuronal antibodies associated with autism and a language disorder. Ann Neurol. 2003;53:533-537.

124. Martin LA, Ashwwood P, Braunschweig D et al. Stereotypies and hyperactivity in rhesus monkeys exponed to IgG from mothers of children with autism. Brain, Behavior, and Immunity. 2008;22:806-816.

125. MRC Review of Autism Research. Epidemiology and Causes. UK. 2001.

126. Demecheli V, Jefferson T, Rivetti A et al. Vacunas para sarampión, parotiditis y rubéola en niños (Revisión Cochrane traducida). En: La Biblioteca Cochrane Plus, 2008 Número 4. Oxford: Update Software Ltd. Disponible en: http://www.update-software. com Abre nueva ventana. (Traducida de The Cochrane Library, 2008 Issue 3. Chichester, UK: John Wiley & Sons, Ltd.).2008.

127. Millward C, Ferriter M, Connell-Jones G. Dietas libres de gluten y caseína para el trastorno del espectro autista (Revisión Cochrane traducida). En: La Biblioteca Cochrane Plus, 2008 Número 4. Oxford: Update Software Ltd. Disponible en: http://www. update-software.com Abre nueva ventana. (Traducida de The Cochrane Library, 2008 Issue 3. Chichester, UK: John Wiley & Sons, Ltd.). 2008.

128. Saemundsen E, Ludvigsson P, Rafnsson V. Risk of autism spectrum disorder after infantile spasms: a population-based study nested in a cohort with seizures in the first year of life. Epilepsia. 2008;49:1865-1870.

129. García-Peñas JJ. Autismo, epilepsia y patología del lóbulo temporal. Rev Neurol. 2009;48:S35-S45.

130. Nishiyama T, Taniai H, Miyachi T et al. Genetic correlation between autistic traits and IQ in a population-based sample of twins with autism spectrum disorders (ASDs). Journal of Human Genetics. 2009;54:56-61.

131. Paula-Pérez I, Martos- Pérez J. Sindrome de Asperger y autismo de alto funcionamiento: comorbilidad con trastornos de ansiedad y del estado del ánimo. Rev Neurol. 2009;48:S31-S34.

132. Ming X, Brimacombe M, Chaaban J et al. Autism spectrum disorders: concurrent clinical disorders. Journal of Child Neurology. 2008;23:6-13.

133. Kim JA, Szatmari P, Bryson SE et al. The prevalence of anxiety and mood problems among children with autism and Asperger syndrome. Autism. 2000;117-132.

134. Ghaziuddin M, Wenger SL, Ghaziuddin N. Comorbidity of Asperger syndrome: a preliminary report. Source Journal of Intellectual Disability Research. 1998;42:279- 283.

135. Russell AJ, Mataix-Cols D, Anson M et al. Obsessions and compulsions in Asperger syndrome and high-functioning autism. British Journal of Psychiatry. 2005;186:525-528.

136. Clinical Practice Guideline. Report of the Recomendations. Autism / Pervasive Developmental Disorders. Assessment and intervention for young children (age 0-3). New York State Departament of Health. Early Intervention Program. 1999.

137. Tidmarsh L VF. Diagnosis and epidemiology of autism spectrum disorders. Can J Psiychiatry 48, 517-525. 2003.

138. López-Ibor JJ, Valdés M, editores. DMS-IV-TR-AP. Manual diagnóstico y estadístico de los trastornos mentales. Texto revisado. Atención Primaria. Barcelona: Masson; 2004.

139. OMS. CIE 10: Trastornos mentales y del comportamiento. Descripciones clínicas y pautas para el diagnóstico. Madrid: MEDITOR, 1992.

140. Kanner L. Autistic Disturbances of Affective Contact. Nerv Child. 1943;2:217-250.

141. Hagberg B, Hanefeld F, Percy A et al. An update in clinically aplicable diagnostic criteria in Rett Síndrome. Eur J Pediatr Neurology. 2002;6:293-297.

142. Charman T, Baird G. Practitioner Review: Diagnosis of autism spectrum disorders in 2 and 3 year ol children. Journal of Child Psychology and Psychiatry. 2002;43(3):249-305.

143. Comité Internacional de Clasificación de la WONCA. Clasificación Internacional de la Atención Primaria: CIAP-2. Barcelona: Masson; 1999.

144. NANDA Internacional. Diagnósticos Enfermeros: Definiciones y Clasificación. 2005; Madrid; 2005-2006: Elsevier.

145. Johnson M, Bulechek G, Butcher H et al. Interrelaciones NANDA, NOC Y NIC. 2007; Madrid: Elsevier.

146. Keren M, Feldman R, Tyano S. Diagnoses and interactive patterns of infants referred to a community-based infant mental health clinic. J Am Acad Child Adolesc Psychiatry. 2001;40:27-35.

147. The classificaton of child and adolescent mental diagnosis in primary care: Diagnosis and Statistical Manual for Primary Care (DSM-PC) Child and Adolescent Version. 1996; Elk Grove, IL: American Academy of Pediatrics.

148. SIGN. Assessment, diagnosis and clinical interventions for children and young people with autism spectrum disorders. A national clinical guideline. 2007.

149. Volkmar FR, Klin A, Siegel B et al. Field trieal for autistic disorder in DSM-IV. Am J Psychiatry. 1994;151:1361-1367.

150. Klin A, Cicchetti DV, Volkmar FR. Brief report: Interrater reliability of clinical diagnosis and DSM-IV criteria for autistic disorder: results of the DSM-IV autism field trial. J Autism Dev Disord. 2000;30:163-167.

151. Volkmar FR, Cicchetti DV, Bregman J. Three diagnostic systems for autism: DSM-III, DSM-III-R, and ICD-10. J Autism Dev Disord. 1992;1992:4-483.

152. Artigas- Pallarés J. Atención precoz de los trastornos del neurodesarrollo. A favor de la intervención precoz de los trastornos del neurodesarrollo. Rev Neurol. 2007;44(3): S31-S34.

153. Guralnick MJ. Effectiveness of early intervention for vulnerable children: a developmental perspective. American Journal on Mental Retardation. 1998;102:319-345.

154. Remignon B, et al. Early intensive behavioral intervention: outcomes for children with autism and their parents after two years. American Journal on Mental Retardation. 2007;112:418-438.

155. Szatmari P, Bryson SE, Boyle MH et al. Predictors of autcome among high functioning children with autism and Asperger syndrome. Journal of Child Psychology and Psychiatry. 2003;44:520-528.

156. Harris SL, Handleman JS. Age and IQ at intake as predictors of placement for young children with autism: a four- to six-year follow-up. Journal of Autism and Developmental Disorders. 2000;30:137-142.

157. Muhle R, Trentacoste SV, Rapin I. The Genetics of Autism. Pediatrics. 2004;113:472-486.

158. Greenberg DA, Hodge SE, Sowinske J et al. Excess of twins among affected sibling pairs with autism: implications for the etiologic of autism. Am.J.Hum.Genet. 2001;69:1062-1067.

159. McMahon WM, Baty BJ, Boyle MH. Genetic Counseling and Ethical Issues for Autism. American Journal of Medical Genetics Par C (Semin Med Genet ). 2006;142:52-57.

160. Freitag CM. The genetics of autistic disorders and its clinical relevance: a review of the literature. Molecular Psychiatry. 2007;12:2-21.

161. BOE. Real Decreto 1030/2006, del 15 de septiembre, por el que se establece la cartera de servicios comunes del Sistema Nacional de Salud y el procedimiento para su actualización 2006.

162. Proyecto AP-21. Marco estratégico para la mejora de la Atención Primaria en España: 2007-2012. Ministerio de Sanidad y Consumo. 2007.

163. Cartera de sevicios estandarizados de Atención Primaria. Comunidad de Madrid. 2007.

164. Galbe Sánchez-Ventura J, Grupo PrevInfad/PAPPS Infancia y Adolescencia. Atención orientada al desarrollo, supervisión del desarrollo psicomotor y cribado de los trastornos del espectro autista. Rev Pediatr Aten Primaria. 2006;8:101-126.

165. Filipek PA, et al. Practice parameter: Screening and diagnosis of autism: Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Child Neurology Society. Neurology. 2000;55:468-479.

166. Frankenburg WK, Dodds JB, Archer P et al. The DENVER II: A major revision and restandardization of the Denver Developmental Screening Test. Pediatrics. 1992;89:91-97.

167. Frankenburg WK, Dodds JB. The Denver Developmental Screening Test. J Pediat. 1967;71:181.

168. Glascoe FP, Byrne L, Ashford L et al. Accuracy of the Denver-II in developmental screening. Pediatrics. 1992;89:1221-1225.

169. Anonimo. Estudio Haizea-Llevant. Servicio Central de Publicaciones. Gobierno Vasco eds. Vitoria. 1991.

170. Fernández Álvarez E. El desarrollo psicomotor de 1.702 niños de 0 a 24 meses de edad. (Tesis doctoral). Universidad de Barcelona 1988. Tabla de desarrollo psicomotor. En: Estudio Haizea Llevant. Servicio central de publicaciones. Gobierno Vasco eds. Victoria. 1991.

171. Ministry of Health. Well Child: Tamariki Ora Schedule. Wellington: Ministry of Health, 1996.

172. Filipek PA, Accardo P, Baranek GT et al. The screening and diagnosis of autistic spectrum disorders. J Autism Dev Disord. 1999;29:439-484.

173. National Autism Plan for Children (NAPC). Plan for the identification, assesment, diagnosis and access to early interventions for pre-school and primary school aged children with autism spectrum disorders (ASD). The National Autistic Society. London. 2003.

174. Chawarska K, Volkmar FR. Chapter 8: Autism in Infancy and Early Childhood. In: Volkmar FR, Paul R, Klin A et al., eds. Handbook of autism and pervasive develomental disorders 3ª Edición. Vol. 1: Diagnosis, development, neurology and behavior.2005; New Jersey: Willey.

175. Guía para la atención de niños con Trastornos del Espectro Autista en Atención Primaria. Junta de Castilla y León. Gerencia Regional de Salud. 2007.

176. English A, Essex J. Report on autistic spectrum disorders: a comprehensive report into identification, training and provision focusing on the needs of children and young people with autistic spectrum disorder and their families within the West Midland region. Warwick: Warwickshire Country Council for the West Midlands, SEN Regional Partnership, 2001.

177. Howlin P, Moore A. Diagnosis in autism: a survey of over 1200 patients in the UK. Autism: International Journal of Research and Practice. 1998;1:135-162.

178. De Giacomo A, Fombonne E. Parental recognition of developmental abnormalities in autism. European Child and Adolescent Psychiatry. 1998;7:131-136.

179. Rogers SJ, Hepburn S, Wehner E. Parent reports of sensory symptoms in toddlers with autism and those with others developmental disorders. J Autism Dev Disord. 2003;33:631-642.

180. Malhi P, Singhi P. Recognition of autism in young children. Stud Psychol. 2003;45:75-80.

181. Glascoe FP. The role of parents in the detection of devlopmental and behavioral problems. Pediatrics. 1995;95:829-836.

182. Glascoe FP, MacLean WE, Stone WL. The importance of parent´s concerns about their child´s behavior. Clinical Pediatrics. 1991;30:8-11.

183. Glascoe FP, Sandler H. Value of parents´estimates of children´s developmental ages. The Journal of Pediatrics. 1995;127:831-835.

184. Grupo de Expertos de Trastornos del Espectro Autista-ISCIII. Análisis del Diagnóstico de afectados de Autismo y Planificación del Registro Español de TEA. Obra Social Caja Madrid.Ayuda a proyectos de Atención a Personas con discapacidad y a sus familias. 2004.

185. Glascoe FP. Cómo utilizar la “evaluación de los padres del nivel de desarrollo” para detectar y tratar problemas del desarrollo y el comportamiento en atención primaria. MTA-Pediatría. 2001;22:225-243.

186. Glascoe FP. Parents´ evaluation of developmental status: how well do parents´ concerns identify children with behavioral and emotional problems? Clinical Pediatrics. 2003;42:133-138.

187. Baron-Cohen S, et al. The early identification of autism: the Checklist for Autism in Toddlers (CHAT). Journal of Developmental and Learning Disorders. 2000;4:3-30.

188. Allison C, Baron-Cohen S, Wheelwrigth S et al. The Q-CHAT (Quantitative CHecklist for Autism in Toddlers): a normally distributed quantitative measure of autistic traits at 18-24 months of age: preliminary report. J Autism Dev Disord. 2008;38:1414- 1425.

189. Robins DL, Fein D, Barton ML et al. The Modified Checklist for Autism in Toddlers: an initial study investigating the early detection of autism and pervasive developmental disorders. J Autism Dev Disord. 2001;31:131-144.

190. Robins DL. Screening for autism spectrum disorders in primary care settings. Autism. 2008;12:537-556.

191. UK National Screening Committee. What is Screening? (citado el 9 de enero de 2009). Disponible en : http://www.nsc.nhs.uk/whatscreening/whatscreen_ind.htm Abre nueva ventana

192. Mawle E, Griffiths P. Screening for autism in pre-school children in primary care: Systematic review of English Language tools. International Journal of Nursing Studies. 2006;43:623-636.

193. Johnson CP, Myers SM, Council on Children with Disabilities. Identification and evaluation of children with autism spectrum disorders. Pediatrics. 2007;120:1183-1215.

194. Berument SK, Rutter M, Lord C et al. Autism screening quiestionnaire: diagnostic validity. British Journal of Psychiatry. 1999;175:444-451.

195. Rutter M, Bailey A, Lord C. Social Communication Questionnaire (SCQ). 2003; Los Angeles: Western Psychological Services.

196. Chandler S, Charman T, Baird G et al. Validation of the social communication questionnaire in a population cohort of children with autism spectrum disorders. J Am Acad Child Adolesc Psychiatry. 2007;46:1324-1332.

197. Charman T, Baird G, Simonoff E et al. Efficacy of three screening instruments in the identification of autistic-spectrum disorders. British Journal of Psychiatry. 2007;191:554-559.

198. Allen CW, Silove N, Williams K et al. Validity of the Social Communication Questionnaire in Assesing Risk of Autism in Preschool Children with Developmental Problems. J Autism Dev Disord. 2007;37:1278.

199. Scott FJ, Baron-Cohen S, Bolton P et al. The CAST (Childhood Asperger Syndrome Test): Preliminary development of a UK screen for mainstream primary-school age children. Autism. 2002;6:9-31.

200. Williams J., Scott FJ, Stott C et al. The CAST (Childhood Asperger Syndrome Test). Autism. 2005;9:45-68.

201. Allison C, Williams J., Scott FJ et al. The Childhood Asperger Syndrome Test (CAST). Autism. 2007;11:177-189.

202. Belinchón M, Hernández JM, Sotillo M. Capítulo 5: Escala Autónoma para la detección del Síndrome de Asperger y el autismo de alto funcionamiento. En: Personas con Síndrome de Asperger. Funcionamiento, detección y necesidades.2008; Madrid.

203. Croen L, Najjar DV, Fireman B et al. Maternal and paternal age and risk of autism spectrum disorders. Arch Pediatr Adolesc Med. 2007;161:334-340.

204. Croen L, Yoshida CK, Odouli R et al. Neonatal hyperbilirubinemia and risk of autism spectrum disorders. Pediatrics. 2005;115:e135-e138.

205. Larsson HJ, et al. Risk factors for autism: perinatal factors, parental psychiatric history, and socioeconomic status. American Journal of Epidemiology. 2005;161:916-925.

206. Schendel D, Karapurkar Bhasin T. Birth weight and gestacional age characteristics of children with autism, including a comparison with other developmental disabilities. Pediatrics. 2008;121:1155-1164.

207. Kolevzon A, Gross R, Reichenberg A. Prenatal and perinatal risk factors for autism. A review and integration of findings. Arch Pediatr Adolesc Med. 2007;161:326-333.

208. Gardener H, Spiegelman D, Buka SL. Prenatal risk factors for autism: comprehensive meta-analysis. The British Journal of Psychiatry. 2009;195:7-14.

209. Durkin MS, et al. Advanced parental age and risk of autism spectrum disorder. American Journal of Epidemiology. 2008;168:1268-1276.

210. Ronald A, Happé F, Bolton P et al. Genetic heterogeneity between the three components of the autism spectrum: a twin study. J Am Acad Child Adolesc Psychiatry. 2006;45:691-699.

211. Landa RJ. Review: Diagnosis of autism spectrum disorders in the first 3 years of life. Nature Clinical Practice Neurology. 2008;4:138-146.

212. Maestro S, et al. Attentional skills during the first 6 months of age in autism spectrum disorder. J Am Acad Child Adolesc Psychiatry. 2002;41:1239-1245.

213. Lord C, Risi S, Dilavore PS et al. Autism fron 2 to 9 years of age. Arch Gen Psychiaty. 2006;63:694-701.

214. Stone WL. Can autism be diagnoses accurately in children under 3 years. Child Psychol Psychiatry. 1999;40:219-226.

215. Wetherby AM, Woods J, Allen L et al. Early indicators of autism spectrum disorders in the second year of life. Journal of Autism and Developmental Disorders. 2004;34:473-493.

216. Osterling J, Dawson G. Early recognition of children with atuism: a study of first birthday home videotapes. Journal of Autism and Developmental Disorders. 1994;24:247-257.

217. Harrington JW, Patrick PA, Edwards KS et al. Parental beliefs about autism: Implications for the treating physician. Autism. 2006;10:462.

218. Brogan CA, Knussen C. The disclosure of a diagnosis of an autistic spectrum disorder: determinants of satisfaction in a sample of Scottish parents. Autism. 2003;7:46.

219. Swanepoel Y. Primary caregivers´ experiences of raising children with autism: a phenomenological perspective. Rhodes University. 2003.

220. Osborne LA, Reed P. Parents´ perceptions of communication with professionals during the diagnosis of autism. Autism. 2008;12:309-324.

221. Rhoades RA, Scarpa A, Salley B. The importance of physician knowledge of autism spectrum disorder: results of a parent survey. BMC Pedatrics. 2007;7.

222. Honey E, Hastings RP, Mcconachie H. Use of questionnaire on resources and stress (QRS-F) with parents of young children with autism. Autism. 2005;9:246-255.

223. Bromley J, Hare DJ, Davison K et al. Mother supporting children with autistic spectrum disorders: social support, mental health status and satisfaction with services. Autism. 2004;8:409-423.

224. Altiere MJ, von Kluge S. Family Functioning and Coping Behaviors in Parents of Children with Autism. Journal of Child & Family Studies. 2009;18:83-92.

225. Wachtel K, Carter AS. Reaction to diagnosis and parenting styles among mothers of young children with ASDs. Autism. 2008;12.

226. Baker-Ericzén MJ, Brookman-Frazee L, Stahmer A. Stress levels and adaptability in parents of toddlers with and without autism spectrum disorders. Research & Practice for Persons with Severe Disabilities. 2005;30:194-204.

227. Gray D. Gender and coping: the parents of children with high functioning autism. Social Science & Medicine. 2003;56:631-642.

228. Olsson MB, Hwang CP. Depression in mothers and fathers of children with intellectual disability. Journal of Intellectual Dissability Research. 2001;45:535-543.

229. Montes G, Halterman JS. Psychological functioning and coping among mothers of children with autism: a population-based study. Pediatrics. 2007;119:10401046.

230. Altiere MJ. Family functioning and coping behaviors in parents of children with autism. Tesis doctoral. 2006.

231. Gray DE. Ten years on: a longitudinal study of families of children with autism. Journal of Intellectual and Developmental Disability. 2002;27:215-222.

232. Gray DE. Coping over time: the parents of children with autism. Journal of Intellectual Disability Research. 2006;50:970-976.

233. Las personas con autismo en el ámbito sanitario. Una guía para profesionales de la salud, familiares y personas con tea. Federación Andaluza de Padres con Hijos con Trastornos del Espectro Autista “Autismo Andalucia” 2007.

234. The National Autistic Society. Patients with autism spectrum disorders: information for health professionals. 2008. [documento Internet]. [Acceso 24 marzo 2009]. http://www.nas.org.uk/nas/jsp/polopoly.jsp?d=128&a=8521&view=print Abre nueva ventana

235. Souders MC, DePaul D, Freeman KG et al. Caring for children and adolescents with autism who require challenging procedures. Pediatric Nursing. 2002;28:555-562.

236. Liss M, et al. Predictors and Correlates of Adaptative Functioning in Children with Developmental Disorders. Journal of Autism and Developmental Disorders. 2001;31:219-230.

237. Charlop-Christy MH, Carpenter M, Le L et al. Using the picture exchange communication system (PECS) with children with autism: assessment of PECS acquisition, speech, socialcommunication behavior, and problem behavior. J Appl Behav Anal. 2002;35:213-231.

238. Bebko JM, Perry A, Bryson S. Multiple method validation study of facilitated communication: II. Individual differences and subgroup results. J Autism Dev Disord. 1996;26:42.

239. Pilebro C, Bäckman B. Teaching oral hygiene to children with autism. International Journal of Paediatric Dentristry. 2005;15:1-9.

240. Schlosser RW, Lee DL. Promoting generalization and maintenance in augmentative and alternative communication: a meta-analysis of 20 years of effectiveness research. AAC: Augmentative and Alternative Communication. 2000;16:208-226.

241. Schlosser RW, Wendt O. Effects of Aumentative and Alternative Communication Intervention on Speech Producction in Children with Autism: A Systematic Review. American Journal of Speech-Language Pathology. 2008;17:212-230.

242. Richdale A. Sleep problems in autism: prevalence, cause, and intervention. Dev Med Child Neurol. 1999;41:60-66.

243. Williams PG, Sears LL, Allard A. Sleep problems in children with autism. J Sleep Res. 2004;265-268.

244. Johnson KL, Malow BA. Sleep in children with autism spectrum disorders. Current Neurology and Neuroscience Reports. 2008;8:155-161.

245. Lopez-Wagner MC, Hoffman CD, Sweeney DP et al. Sleep problems of parents of typically developing children and parents of children with autism. The Journal of Genetic Psychology. 2008;169:245-259.

246. Black C, Kaye JA, Jick H. Relation of childhood gastrointestinal disorders to autism: Nested case-control study using data from the UK general practice research database. Br Med J. 2002;325:419-421.

247. Schreck KA, Williams K, Smith AF. A comparison of eating behavior between children with and without autism. J Autism Dev Disord. 2004;2004:4-433.

248. Kodak T, Piazza CC. Assessment and behavioral treatment of feeding and sleeping disorders in children with autism spectrum disorders. Child Adolesc Psychiatr Clin N Am. 2008;17:887-905.

249. Lockner DW, Crowe TK, Skipper BJ. Dietary intake and parent´s perception of mealtime behavior in preschool-age children with autism spectrum disorder and in typically developing children. J Am Diet Assoc. 2008;108:1360-1363.

250. Valicenti-McDermott M, McVicar K, Cohen H et al. Gastrointestinal symptoms in children with an autism spectrum disorder and language regression. Pediatric Neurology. 2008;39:392-398.

251. Smith RA, Farnworth H, Wright B et al. Are there more bowel symptoms in children with autism compared to normal children and children with other developmental and neurological disorders?: A case control study. Autism. 2009;13:343-355.

252. Molloy CA, Manning-Courtney P. Prevalence of chronic gastrointestinal symptoms in children with autism and autistic spectrum disorders. Autism. 2003;7:165-171.

253. Williams KW, Wray JJ, Wheeler DM. Secretina intravenosa para el trastorno del espectro autista (Revisión Cochrane traducida). En: La Biblioteca Cochrane Plus, 2008 Número 2. Oxford: Update Software Ltd. Disponible en: http://www.update-software.com Abre nueva ventana. (Traducida de The Cochrane Library, 2008 Issue 2. Chichester, UK: John Wiley & Sons, Ltd.). 2005.

254. Nye C, Brice A. Tratamiento combinado con vitamina B6 y magnesio para el trastorno del espectro autista (Revisión Cochrane traducida). En: La Biblioteca Cochrane Plus, 2008 Número 2. Oxford: Update Software Ltd. Disponible en: http://www.update-software.com Abre nueva ventana. (Traducida de The Cochrane Library, 2008 Issue 2. Chichester, UK: John Wiley & Sons, Ltd.). 2005.

255. Bolman WM, Richmond JA. A double-blind, placebo-controlled, crossover pilot trial or low dose dimethylglycine in patients with autistic disorder. J Autism Dev Disord. 1999;29:191-194.

256. Kern JK, Miller VS, Cauller PL et al. Effectiveness of N, N-dimethylglycine in autism and pervasive developmental disorder. J Child Neurol. 2001;16:169-173.

257. Bent S, Bertoglio K, Hendren RL. Omega-3 fatty acids for autistic spectrum disorders: a systematic review. J Autism Dev Disord. 2009;39:1145-1154.

258. Sinha Y, Silove N, Wheeler D et al. Entrenamiento en integración auditiva y otros tratamientos acústicos para trastornos del espectro autista (Revisión Cochrane traducida). En: La Biblioteca Cochrane Plus, 2008 Número 4. Oxford: Update Software Ltd. Disponible en: http://www.update-software.com Abre nueva ventana. (Traducida de The Cochrane Library, 2008 Issue 3. Chichester, UK: John Wiley & Sons, Ltd.). 2008.

259. Agence d’évaluation des technologies et des modes d’intervention en santé (AETMIS). The role of hyperbaric oxygen therapy in the management of autism: Summary. Report prepared for AETMIS by Khalil Moqadem and Gilles Pineau. Montréal: AETMIS, 2007 (AETMIS 07-11).

260. Niederhofer H, Staffen W, Mair A. Inmunoglobulins as an alternative strategy of psichopharmacological treatment of children with autistic disorder. Neuropsychopharmacology. 2003;28:1014-1015.

261. Levy SE, Hyman S. Novel Treatment for autistic spectrum disorders. Mental Retardation and Developmental Disabilities Research Reviews. 2005;11:131-142.

262. Mitka M. Chelation Therapy Trials Halted. JAMA. 2008;300:2236.

263. Baxter AJ, Krenzelok EP. Pediatric fatality secondary to EDTA chelation. Clinical toxicology. 2008;46:1083-1084.

264. Levy SE, Hyman SL. Use of complementary and alternative treatments for children with autistic spectrum disorders is increasing. Pediatric Annals. 2003;32:685-691.

265. Scottish Intercollegiate Guidelines Network. A guideline developers’ handbook (Publication n° 50) [monografía en Internet]. Edinburgh: SIGN: 2001. Scottish Intercollegiate Guidelines Network 2004 [cited 2007 Dec 10]; Disponible en: URL: http://www.sign.ac.uk/guidelines/fulltext/50/index.htmlAbre nueva ventana.

266. National Institute for Clinical Excellence. The guidelines manual.[monografía en Internet]. London: NICE: 2004. National Institute for Clinical Excellence 2007 April 13 [cited 2008 May 15]; Disponible en: URL: http://www.nice.org.uk/page.aspx?o=422950 Abre nueva ventana.

 

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